Zobrazeno 1 - 10
of 34
pro vyhledávání: '"C. Adkin"'
Autor:
James I. Bruce, Patrick J. O’Connell, Peter G. Taylor, David P.T. Smith, Roy C. Adkin, Victoria K. Pearson
Publikováno v:
Molecules, Vol 25, Iss 18, p 4253 (2020)
The relaxivity of MRI contrast agents can be increased by increasing the size of the contrast agent and by increasing concentration of the bound gadolinium. Large multi-site ligands able to coordinate several metal centres show increased relaxivity a
Externí odkaz:
https://doaj.org/article/815ce9d17375419aac6a59a7bd733118
Autor:
Peter G. Taylor, Roy C. Adkin, James I. Bruce, Patrick J. O’Connell, David P.T. Smith, Victoria K. Pearson
Publikováno v:
Molecules, Vol 25, Iss 4253, p 4253 (2020)
Molecules
Volume 25
Issue 18
Molecules
Volume 25
Issue 18
The relaxivity of MRI contrast agents can be increased by increasing the size of the contrast agent and by increasing concentration of the bound gadolinium. Large multi-site ligands able to coordinate several metal centres show increased relaxivity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1541934db3259f432ff233fed4e70568
http://oro.open.ac.uk/72280/1/72280.pdf
http://oro.open.ac.uk/72280/1/72280.pdf
Autor:
Abbie M. Adams, C. Adkin, Penelope L. Meloni, Steve D. Wilton, Francesco Muntoni, Sue Fletcher, Brenda Wong
Publikováno v:
Neuromuscular Disorders
Manipulation of dystrophin pre-mRNA processing offers the potential to overcome mutations in the dystrophin gene that would otherwise lead to Duchenne muscular dystrophy. Dystrophin mutations will require the removal of one or more exons to restore t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f161ad68e175c01e6cead4462c8ee07
http://europepmc.org/articles/PMC3488593
http://europepmc.org/articles/PMC3488593
Publikováno v:
Radiotherapy and Oncology. 123:S577-S578
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ef8c82ae463ac02a889c0ba68c2e4c1b
https://doi.org/10.1016/s0167-8140(17)31483-4
https://doi.org/10.1016/s0167-8140(17)31483-4
Publikováno v:
Radiotherapy and Oncology. 127:S361
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3feb12f8d4c11eab250847b33a8162c1
https://doi.org/10.1016/s0167-8140(18)31016-8
https://doi.org/10.1016/s0167-8140(18)31016-8
Autor:
Luisa Boldrin, C. Adkin, Jennifer E. Morgan, Francesco Muntoni, Jinhong Meng, Virginia Arechavala-Gomeza
Publikováno v:
Neuromuscular Disorders. 20:6-15
Stem cell therapy holds promise for treating muscle diseases. Although satellite cells regenerate skeletal muscle, they only have a local effect after intra-muscular transplantation. Alternative cell types, more easily obtainable and systemically-del
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::63492f6ee0e686a6033647d6073bba6b
https://doi.org/10.1016/j.nmd.2009.11.007
https://doi.org/10.1016/j.nmd.2009.11.007
Autor:
C. Adkin, Steve D. Wilton, Ian R. Graham, Maria Kinali, Dominic J. Wells, Francesco Muntoni, Emma J. Ashton, Mary A. Rutherford, Virginia Arechavala-Gomeza, Caroline McCulley, Caroline Sewry, Ryszard Kole, George Dickson, M. E. Garralda, D. Hunt, Lucy Feng, Sebahattin Cirak, Kate Bushby, Stephen Abbs, Michela Guglieri, Matthew J.A. Wood, Volker Straub, Linda Popplewell, Petros Nihoyannopoulos, Jennifer E. Morgan
Publikováno v:
Lancet Neurology
Summary Background Mutations that disrupt the open reading frame and prevent full translation of DMD , the gene that encodes dystrophin, underlie the fatal X-linked disease Duchenne muscular dystrophy. Oligonucleotides targeted to splicing elements (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::630b862a47d005278fd3823a5acd181c
http://europepmc.org/articles/PMC2755039
http://europepmc.org/articles/PMC2755039
Publikováno v:
Methods in Molecular Biology ISBN: 9781617797668
We have taken an empirical approach in designing splice-switching oligomers to induce targeted dystrophin exon skipping. The nucleotide sequence of the exon under examination is first analyzed for potential exon recognition motifs and then a set of o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dac42ff2177a9943a6c6aa2f6f231a26
https://doi.org/10.1007/978-1-61779-767-5_11
https://doi.org/10.1007/978-1-61779-767-5_11
Autor:
Sue Fletcher, C. Adkin, Brenda Wong, K. Greer, Penny Meloni, Steve D. Wilton, Francesco Muntoni, Ryszard Kole, Clayton T. Fragall, Russell D. Johnsen
Publikováno v:
Molecular Therapy. Nucleic Acids
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Molecular Therapy: Nucleic Acids, Vol 1, Iss C (2012)
Protein-truncating mutations in the dystrophin gene lead to the progressive muscle wasting disorder Duchenne muscular dystrophy, whereas in-frame deletions typically manifest as the milder allelic condition, Becker muscular dystrophy. Antisense oligo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6af523c2e65bc293d91e1645cefc8ca6
Publikováno v:
PLoS ONE
PLoS ONE, Vol 6, Iss 3, p e17454 (2011)
PLoS ONE, Vol 6, Iss 3, p e17454 (2011)
BackgroundStem cell transplantation is a promising potential therapy for muscular dystrophies, but for this purpose, the cells need to be systemically-deliverable, give rise to many muscle fibres and functionally reconstitute the satellite cell niche
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::401ca22249866363eff31b915434b541
http://europepmc.org/articles/PMC3052358
http://europepmc.org/articles/PMC3052358