Zobrazeno 1 - 10
of 21
pro vyhledávání: '"C. A. Richard Boyd"'
Autor:
Karl J. Morten, Joanna Poulton, C. A. Richard Boyd, Eszter Dombi, Manu Vatish, Sajida Malik, Alan Diot
Publikováno v:
Oncotarget
Exposure to maternal malnutrition impairs postnatal health. Acute nutritional stress is less clearly implicated in intrauterine programming. We studied the effects of stressing pregnant mothers on perinatal growth and adult glucose homeostasis. We co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68209841825bf103b625f7bd98f58c7a
http://europepmc.org/articles/PMC5752535
http://europepmc.org/articles/PMC5752535
This timely meeting brought together groups with shared interests in the regulation and effects of the mammalian Target Of Rapamycin (mTOR, see Figure 1), a highly conserved serine/threonine protein kinase with roles in cell metabolism, cell growth a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::022f2ad4638bcc97cc2dae8f31fc7f59
https://ora.ox.ac.uk/objects/uuid:c4ac6e5b-b0d7-4715-8d50-95f433920652
https://ora.ox.ac.uk/objects/uuid:c4ac6e5b-b0d7-4715-8d50-95f433920652
Autor:
Margret H. Ogmundsdottir, Bruno Reynolds, Deborah C.I. Goberdhan, C. A. Richard Boyd, Shubana Kazi, Clive Wilson, Shivanthy M. Visvalingam
mTOR (mammalian target of rapamycin) plays a key role in determining how growth factor, nutrient and oxygen levels modulate intracellular events critical for the viability and growth of the cell. This is reflected in the impact of aberrant mTOR signa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ad8090cfdb3d024b53777d7a286bf260
https://doi.org/10.1042/bst0370248
https://doi.org/10.1042/bst0370248
Autor:
C. A. Richard Boyd, Bruno Reynolds, Deborah C.I. Goberdhan, Robert Laynes, Shubana Kazi, Pietro Roversi
Publikováno v:
Biochemical Journal. 420:363-372
Mammalian CD98 heterodimeric amino acid transporters consist of a promiscuous single-pass transmembrane glycoprotein, CD98hc (CD98 heavy chain), and one of six multipass transmembrane proteins or ‘light chains’. The heterodimeric complexes of CD9
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1049732e6a5093e1ca0d47eec19a258
https://doi.org/10.1042/bj20082198
https://doi.org/10.1042/bj20082198
Autor:
Theresa L. Powell, Thomas Jansson, Mark A. Turner, Colin P. Sibley, Irene Cetin, Paul T.-Y. Ayuk, Jocelyn D. Glazier, Susan L. Greenwood, Stephen W D'Souza, C. A. Richard Boyd
Publikováno v:
Pediatric Research. 58:827-832
The placenta is essential to nutrition before birth. Recent work has shown that a range of clearly defined alterations can be found in the placentas of infants with intrauterine growth restriction (IUGR). In the mouse, a placental specific knockout o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58cb480395102899cf9d01914444d65b
https://doi.org/10.1203/01.pdr.0000181381.82856.23
https://doi.org/10.1203/01.pdr.0000181381.82856.23
Autor:
Corinna J. Sword, Nishan Guha, Keith M. Morgan, Ian D. Collier, David Meredith, C S Temple, Patrick D. Bailey, C. A. Richard Boyd
Publikováno v:
European Journal of Biochemistry. 267:3723-3728
The binding affinities of a number of amino-acid and peptide derivatives by the mammalian intestinal peptide transporter PepT1 were investigated, using the Xenopus laevis expression system. A series of blocked amino acids, namely N-acetyl-Phe (Ac-Phe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9becb5e5f572246f38af7e257a83d50
https://doi.org/10.1046/j.1432-1327.2000.01405.x
https://doi.org/10.1046/j.1432-1327.2000.01405.x
Autor:
J. Ramsey Bronk, C S Temple, Keith M. Morgan, Ian D. Collier, Patrick D. Bailey, David Meredith, C. A. Richard Boyd
Publikováno v:
Angewandte Chemie. 112:515-518
By building key structural features into hydrophilic drugs, they can be recognized by the PepT1 transporter system of the small intestine and rendered orally active. The model shown provides, for the first time, a 3D template for all known substrates
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fe3c0f073702651ddcac32338dc054c
https://doi.org/10.1002/(sici)1521-3757(20000204)112:3<515::aid-ange515>3.0.co
https://doi.org/10.1002/(sici)1521-3757(20000204)112:3<515::aid-ange515>3.0.co
Autor:
You-Jun Fei, C. A. Richard Boyd, Frederick H. Leibach, Eiji Nara, Jin-Cai Liu, Vadivel Ganapathy
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1418:344-351
We investigated the interaction of rat PEPT2, a high-affinity peptide transporter, with neutral, anionic, and cationic dipeptides using electrophysiological approaches as well as tracer uptake methods. d-Phe-L-Gln (neutral), d-Phe-L-Glu (anionic), an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::34559836afd54663c470578f52f22140
https://doi.org/10.1016/s0005-2736(99)00046-2
https://doi.org/10.1016/s0005-2736(99)00046-2
Autor:
C. A. Richard Boyd, Patrick D. Bailey, John. P. George, David Meredith, Richard A. Price, Keith M. Morgan, Ian D. Collier, Rachel Pettecrew, George L. Kellett
Publikováno v:
Chem. Commun.. :323-325
A quantitative method has been developed for determining the affinity of substrates for the peptide transporter PepT1, allowing oral availability of drugs via PepT1 to be estimated.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e03379473e0d1c3cbedf3f79f53c51f6
https://doi.org/10.1039/b511996k
https://doi.org/10.1039/b511996k
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Biomembranes. 1324(2):245-250
Four hydrolysis-resistant dipeptides (D-phenylalanyl-L-alanine, D-phenylalanyl-L-glutamine, D-phenylalanyl-L-glutamate and D-phenylalanyl-L-lysine) were synthesized to investigate the effects of net charge on transmural dipeptide transport by isolate
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99a6d792141e42e56a9b20397b2f61cd