Zobrazeno 1 - 10
of 11
pro vyhledávání: '"C. A. M. Erkelens"'
Autor:
Epie Boven, W.J.F. van der Vijgh, Frederick H. Hausheer, C. A. M. Erkelens, Miranda Verschraagen, T.M Hulscher, H.M. Pinedo
Publikováno v:
European Journal of Cancer. 38:1148-1156
BNP7787 (2',2'-dithio-bis-ethane sulphonate sodium), a water-soluble disulphide, is chemically and mechanistically different from other sulphur-containing chemoprotective agents. Presently, BNP7787 is under investigation for its protective properties
Autor:
Epie Boven, G. M. Kolfschoten, Hennie M.M. Schlüper, Herbert M. Pinedo, C. A. M. Erkelens, Peter G. Scheffer
Publikováno v:
Gynecologic Oncology. 76:362-368
Objectives. We have established a panel of 15 human ovarian cancer xenografts grown subcutaneously in the flank of the nude mouse. Similar to the clinic, the xenografts show differences in histological subtype and volume doubling time. We determined
Autor:
Peter G. Scheffer, Wilbert H.M. Peters, Hennie M.M. Schlüper, C. A. M. Erkelens, A. H. Van Hattum, Epie Boven, C. M. Kuiper, G. Giaccone, H.M. Pinedo, J. van Ark-Otte
Publikováno v:
Scopus-Elsevier
British Journal of Cancer
British Journal of Cancer
We have established ten transplantable human soft-tissue sarcoma (STS) xenografts grown as subcutaneous tumours in the nude mouse. Nine xenografts originated from patients that needed chemotherapy in the course of their disease. The xenografts were t
Publikováno v:
British Journal of Cancer
N-l-leucyl-doxorubicin and vinblastine-isoleucinate can be considered as relatively non-toxic prodrugs from doxorubicin and vinblastine, respectively. A comparative analysis was carried out of the anti-tumour activity of the four compounds as well as
Autor:
W.J.F. van der Vijgh, Epie Boven, Frederick H. Hausheer, Miranda Verschraagen, C. A. M. Erkelens, Emine Torun
Publikováno v:
Verschraagen, M, Boven, E, Torun, E, Erkelens, CA, Hausheer, FH & van der Vijgh, WJ 2004, ' Pharmacokinetic behaviour of the chemoprotectants BNP7787 and mesna after an i.v. bolus injection in rats. ', British Journal of Cancer, vol. 90, no. 8, pp. 1654-9 . https://doi.org/10.1038/sj.bjc.6601719
British Journal of Cancer
British Journal of Cancer, 90(8), 1654-9. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer, 90(8), 1654-9. Nature Publishing Group
In preclinical studies, BNP7787 (disodium 2,2'-dithio-bis-ethane sulphonate), the disulphide form of mesna, has demonstrated selective protection against cisplatin-induced nephrotoxicity due to conversion into mesna inactivating toxic platinum specie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c7a22bf8fdeb4e0ea7769340c1e50ef
https://research.vumc.nl/ws/files/10002512/PMC2410273
https://research.vumc.nl/ws/files/10002512/PMC2410273
Autor:
H.M. Pinedo, Ruben Gerardus George Leenders, Epie Boven, Johan Wilhelm Scheeren, P. H. J. Houba, Hidde J. Haisma, C. A. M. Erkelens
Publikováno v:
British Journal of Cancer
The prodrug N-[4-(daunorubicin-N-carbonyl-oxymethyl)phenyl] O-beta-glucuronyl carbamate (DNR-GA3) was synthesized for specific activation by human beta-glucuronidase, released in necrotic areas of tumour lesions. In vitro, DNR-GA3 was 18 times less t
Autor:
J. van Ark-Otte, C. A. M. Erkelens, W. J. M. Jansen, G. M. Kolfschoten, H.M. Pinedo, Epie Boven
Publikováno v:
International Journal of Cancer, 73, 891-896. Wiley-Liss Inc.
Jansen, W J M, Kolfschoten, G M, Erkelens, C A M, van Ark-Otte, J, Pinedo, H M & Boven, E 1997, ' Antitumor activtiy of CPT-11 in experimental human ovarian cancer and soft-tissue sarcoma ', International Journal of Cancer, vol. 73, pp. 891-896 . https://doi.org/10.1002/(SICI)1097-0215(19971210)73:6<891::AID-IJC22>3.0.CO;2-6
Jansen, W J M, Kolfschoten, G M, Erkelens, C A M, van Ark-Otte, J, Pinedo, H M & Boven, E 1997, ' Antitumor activtiy of CPT-11 in experimental human ovarian cancer and soft-tissue sarcoma ', International Journal of Cancer, vol. 73, pp. 891-896 . https://doi.org/10.1002/(SICI)1097-0215(19971210)73:6<891::AID-IJC22>3.0.CO;2-6
CPT-11, a semi-synthetic derivative of camptothecin, was investigated for its activity in panels of 15 human ovarian-cancer lines and 10 human soft-tissue sarcoma lines grown s.c. in nude mice. Various factors were analyzed that may be of influence o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f9d8b16babd490d748c409f2ba78aa29
https://research.vumc.nl/en/publications/6a62de0b-4f72-46fe-9bbf-61127d9878d5
https://research.vumc.nl/en/publications/6a62de0b-4f72-46fe-9bbf-61127d9878d5
Publikováno v:
Annals of oncology : official journal of the European Society for Medical Oncology. 4(4)
Summary Background The new cytostatic agent taxol has clearly demonstrated its effectiveness in ovarian cancer patients. The synthesis of drugs related to taxol could overcome its limited natural supply and may have additional benefits, such as great
Publikováno v:
British Journal of Cancer, 68, 52-62. Nature Publishing Group
Boven, E, Schipper, H, Erkelens, C A M, Hatty, S A & Pinedo, H M 1993, ' The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer ', British Journal of Cancer, vol. 68, pp. 52-62 .
British Journal of Cancer
Boven, E, Schipper, H, Erkelens, C A M, Hatty, S A & Pinedo, H M 1993, ' The influence of the schedule and the dose of gemcitabine on the anti-tumour efficacy in experimental human cancer ', British Journal of Cancer, vol. 68, pp. 52-62 .
British Journal of Cancer
The therapeutic efficacy of gemcitabine, a new nucleoside analogue, was assessed in a variety of well-established human soft tissue sarcoma and ovarian cancer xenografts grown s.c. in nude mice. Tumour lines selected had different histological subtyp
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41dc7aa388043320bd7c2d84f17d5681
https://research.vumc.nl/en/publications/ba47db38-1f9e-41e0-a3ba-776dae06cee6
https://research.vumc.nl/en/publications/ba47db38-1f9e-41e0-a3ba-776dae06cee6
Publikováno v:
Boven, E, Erkelens, C A, Luning, M & Pinedo, H M 1990, ' Activity of GR30921X (NSC 382057) and GR63178A (NSC D611615) in human ovarian cancer lines ', British Journal of Cancer, vol. 61, no. 5, pp. 709-711 .
British Journal of Cancer, 61(5), 709-711. Nature Publishing Group
British Journal of Cancer
British Journal of Cancer, 61(5), 709-711. Nature Publishing Group
British Journal of Cancer
Compounds of a new group of pentacyclic pyrroloquinones have been shown to have activity against several experimental tumour systems. The first product to be considered for clinical evaluation was GR30921X (NSC 382057) (Figure 1). The drug appeared t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b98270efabbd53784877bf5bcc6400d
https://research.vumc.nl/ws/files/9065555/8355
https://research.vumc.nl/ws/files/9065555/8355