Zobrazeno 1 - 10 of 1 219 pro vyhledávání: '"C. A. Hart"'
1
Akademický článek
SIRT3 activation promotes enteric neurons survival and differentiation
Autor: Arun Balasubramaniam, Ge Li, Anita Ramanathan, Simon Musyoka Mwangi, C. Michael Hart, Jack L. Arbiser, Shanthi Srinivasan
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-12 (2022)
Abstract Enteric neuron degeneration has been observed during aging, and in individuals with metabolic dysfunction including obesity and diabetes. Honokiol, a naturally occurring compound, is an activator of Sirtuin-3 (SIRT3) that has antioxidant act
Externí odkaz: https://doaj.org/article/9f3ac1106c164679b78f7efd63352a3e
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2
Akademický článek
Accessible decision support for sustainable energy systems in developing countries
Autor: Maria C. G. Hart, Sarah Eckhoff, Michael H. Breitner
Publikováno v: Energy Informatics, Vol 5, Iss 1, Pp 1-22 (2022)
Abstract With rising electricity demand through digitization and innovation, the urgency of climate change mitigation, and the recent geopolitical crisis, stakeholders in developing countries face the complex task to build reliable, affordable, and l
Externí odkaz: https://doaj.org/article/0264129a6f4e4a79857d081b92ca008d
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3
Akademický článek
Glial cell derived neurotrophic factor prevents western diet and palmitate-induced hepatocyte oxidative damage and death through SIRT3
Autor: Simon Musyoka Mwangi, Ge Li, Arun Balasubramaniam, Didier Merlin, Paul A. Dawson, Young C. Jang, C. Michael Hart, Mark J. Czaja, Shanthi Srinivasan
Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-10 (2022)
Abstract Nonalcoholic fatty liver disease (NAFLD) is associated with increased oxidative stress that leads to hepatocyte and mitochondrial damage. In this study we investigated the mechanisms involved in the induction of oxidative stress and impairme
Externí odkaz: https://doaj.org/article/556901cf6394459b8308f062a92d5843
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4
Akademický článek
Laminar flow substantially affects the morphology and functional phenotype of glomerular endothelial cells.
Autor: Daan C 't Hart, Johan van der Vlag, Tom Nijenhuis
Publikováno v: PLoS ONE, Vol 16, Iss 5, p e0251129 (2021)
Shear stress induced by laminar blood flow has a profound effect on the morphology and functional phenotype of macrovascular endothelial cells. The influence of laminar flow on the glomerular microvascular endothelium, however, remains largely elusiv
Externí odkaz: https://doaj.org/article/79d92ac9fcad446ba1aba23c1003ca20
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5
Pharmacological reversal of post-transcriptional alterations implicated in alcohol-induced alveolar macrophage dysfunction
Autor: Samantha M. Yeligar, Frank L. Harris, Lou Ann S. Brown, C. Michael Hart
Publikováno v: Alcohol. 106:30-43
Alcohol use disorders (AUD) cause alveolar macrophage (AM) immune dysfunction and increase risk of lung infections. Excessive alcohol use causes AM oxidative stress which impairs AM phagocytosis and pathogen clearance from the alveolar space. Alcohol
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bbae4aced6ab1bdac67c561680698aaf
https://doi.org/10.1016/j.alcohol.2022.10.003
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9
Long noncoding RNAs in cardiometabolic disorders
Autor: Rio P. Juni, Kelly C. 't Hart, Riekelt H. Houtkooper, Reinier A. Boon
Publikováno v: Juni, R P, 't Hart, K C, Houtkooper, R H & Boon, R A 2022, ' Long noncoding RNAs in cardiometabolic disorders ', FEBS Letters, vol. 596, no. 11, pp. 1367-1387 . https://doi.org/10.1002/1873-3468.14370
The advancement of medical technology has led not only to an increase in life expectancy but also to a rise in aging-related diseases. Aging promotes metabolic disorders, in turn affecting cardiovascular health. Derailment of biological processes in
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b42bc2b871c8d115d631845bb4fc033
https://doi.org/10.1002/1873-3468.14370
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