Complementary activities of DOT1L and Menin inhibitors in MLL-rearranged leukemia

Autor: Florian Nigsch, Júlia Aguadé-Gorgorió, J Gräsel, H Méreau, B Schacher Engstler, Beat Bornhauser, Louise Barys, William R. Sellers, J-P Bourquin, Gregory R. Hoffman, C Stork-Fux, Ralph Tiedt, Caroline Dafflon, Francesco Hofmann, Juerg Schwaller, Swann Gaulis, A Proske, Masato Murakami, V J Craig, Moriko Ito

Publikováno v: Leukemia

Chromosomal rearrangements of the mixed lineage leukemia (MLL/KMT2A) gene leading to oncogenic MLL-fusion proteins occur in ~10% of acute leukemias and are associated with poor clinical outcomes, emphasizing the need for new treatment modalities. Inh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e46228ead23212fd3eb0117f0575ce65
https://doi.org/10.1038/leu.2016.327

[Lower right abdominal pain in a young woman : An ordinary appendicitis]

Autor: S, Haller, V, Kölzer, C A, Fux, C, Glaser, G, Cathomas

Publikováno v: Der Chirurg; Zeitschrift fur alle Gebiete der operativen Medizen. 88(2)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::390b365ffb156292b408a2d986fb1449
https://pubmed.ncbi.nlm.nih.gov/27484829

HIV-1 Transmission During Recent Infection and During Treatment Interruptions as Major Drivers of New Infections in the Swiss HIV Cohort Study

Autor: Alex, Marzel, Mohaned, Shilaih, Wan-Lin, Yang, Jürg, Böni, Sabine, Yerly, Thomas, Klimkait, Vincent, Aubert, Dominique L, Braun, Alexandra, Calmy, Hansjakob, Furrer, Matthias, Cavassini, Manuel, Battegay, Pietro L, Vernazza, Enos, Bernasconi, Huldrych F, Günthard, Roger D, Kouyos, V, Aubert, M, Battegay, E, Bernasconi, J, Böni, H C, Bucher, C, Burton-Jeangros, A, Calmy, M, Cavassini, G, Dollenmaier, M, Egger, L, Elzi, J, Fehr, J, Fellay, H, Furrer, C A, Fux, M, Gorgievski, H F, Günthard, D, Haerry, B, Hasse, H H, Hirsch, M, Hoffmann, I, Hösli, C, Kahlert, L, Kaiser, O, Keiser, T, Klimkait, R D, Kouyos, H, Kovari, B, Ledergerber, G, Martinetti, B Martinez, de Tejada, K, Metzner, N, Müller, D, Nadal, D, Nicca, G, Pantaleo, A, Rauch, S, Regenass, M, Rickenbach, C, Rudin, F, Schöni-Affolter, P, Schmid, J, Schüpbach, R, Speck, P, Tarr, A, Trkola, P L, Vernazza, R, Weber, S, Yerly

Publikováno v: Clinical Infectious Diseases, Vol. 62, No 1 (2016) pp. 115-122
Marzel, Alex; Shilaih, Mohaned; Yang, Wan-Lin; Böni, Jürg; Yerly, Sabine; Klimkait, Thomas; Aubert, Vincent; Braun, Dominique L; Calmy, Alexandra; Furrer, Hansjakob; Cavassini, Matthias; Battegay, Manuel; Vernazza, Pietro L; Bernasconi, Enos; Günthard, Huldrych F; Kouyos, Roger D (2016). HIV-1 Transmission During Recent Infection and During Treatment Interruptions as Major Drivers of New Infections in the Swiss HIV Cohort Study. Clinical infectious diseases, 62(1), pp. 115-122. Oxford University Press 10.1093/cid/civ732

BACKGROUND Reducing the fraction of transmissions during recent human immunodeficiency virus (HIV) infection is essential for the population-level success of "treatment as prevention". METHODS A phylogenetic tree was constructed with 19 604 Swiss seq

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::833646a754db9dc1fb6ed847d10179a8
https://archive-ouverte.unige.ch/unige:110040

Assessing the Paradox Between Transmitted and Acquired HIV Type 1 Drug Resistance Mutations in the Swiss HIV Cohort Study From 1998 to 2012

Autor: Hans H. Hirsch, A. Calmy, Irene Hösli, Nicolas Müller, Manuel Battegay, Pietro Vernazza, Laurent Kaiser, G. Dollenmaier, Andri Rauch, Cyril Shah, Franziska Schöni-Affolter, Sabine Yerly, S Yerly, Olivia Keiser, Karin J. Metzner, Jörg Schüpbach, Patrick Schmid, Barbara Hasse, E Bernasconi, Roger D. Kouyos, Christian R Kahlert, Günthard Hf, Jan Fehr, Meri Gorgievski, P. Vernazza, Matthias Hoffmann, Stephan Regenass, M. Cavassini, B Martinez de Tejada, Gladys Martinetti, Jürg Böni, Hansjakob Furrer, RD Kouyos, C. A. Fux, B. Ledergerber, Leonhard Held, Christoph Rudin, Dunja Nicca, Martin Rickenbach, M Egger, Rainer Weber, Alexandra U. Scherrer, Huldrych F. Günthard, H Furrer, G. Pantaleo, Jacques Fellay, A. Telenti, D Haerry, Roberto F. Speck, Heiner C. Bucher, David Nadal, Matthias Cavassini, Vincent Aubert, Helen Kovari, Thomas Klimkait, Bruno Ledergerber, Enos Bernasconi, T Klimkait, V Aubert, L. Elzi, Philip E. Tarr, M Battegay, Alexandra Trkola, Wan-Lin Yang, Claudine Burton-Jeangros, J Böni

Publikováno v: The Journal of Infectious Diseases
The Journal of Infectious Diseases, Vol. 212, No 1 (2015) pp. 28-38
Journal of Infectious Diseases, vol. 212, no. 1, pp. 28-38
The Journal of infectious diseases
JOURNAL OF INFECTIOUS DISEASES

BACKGROUND: Transmitted human immunodeficiency virus type 1 (HIV) drug resistance (TDR) mutations are transmitted from nonresponding patients (defined as patients with no initial response to treatment and those with an initial response for whom treat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::64087141fedda7be4de99ab9eb82f6a8
https://pubmed.ncbi.nlm.nih.gov/25576598

The rate of recovery in renal function when patients with HIV infection discontinue treatment with tenofovir

Autor: J, Young, Q, Wang, C A, Fux, E, Bernasconi, H, Furrer, P, Vernazza, A, Calmy, M, Cavassini, R, Weber, M, Battegay, H C, Bucher, S, Yerly

Publikováno v: HIV medicine. 15(8)

Tenofovir is associated with reduced renal function. It is not clear whether patients can be expected to fully recover their renal function if tenofovir is discontinued.We calculated the estimated glomerular filtration rate (eGFR) for patients in the

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5e633cdfdd0146392ca4fadbad5c5325
https://pubmed.ncbi.nlm.nih.gov/24641488