Zobrazeno 1 - 10
of 315
pro vyhledávání: '"C. A. Dinarello"'
Autor:
M. Badii, O. I. Gaal, M. C. Cleophas, V. Klück, R. Davar, E. Habibi, S. T. Keating, B. Novakovic, M. M. Helsen, N. Dalbeth, L. K. Stamp, D. Macartney-Coxson, A. J. Phipps-Green, H. G. Stunnenberg, C. A. Dinarello, T. R. Merriman, M. G. Netea, T. O. Crişan, L. A. B. Joosten
Publikováno v:
Arthritis Research & Therapy, Vol 23, Iss 1, Pp 1-11 (2021)
Abstract Objectives Hyperuricemia is a metabolic condition central to gout pathogenesis. Urate exposure primes human monocytes towards a higher capacity to produce and release IL-1β. In this study, we assessed the epigenetic processes associated to
Externí odkaz:
https://doaj.org/article/671704b4770745959533a3055de23ad9
Autor:
M. C. P. Cleophas, T. O. Crişan, V. Klück, N. Hoogerbrugge, R. T. Netea-Maier, C. A. Dinarello, M. G. Netea, L. A. B. Joosten
Publikováno v:
Arthritis Research & Therapy, Vol 21, Iss 1, Pp 1-11 (2019)
Abstract Background Acute gouty arthritis currently is the most common form of inflammatory arthritis in developed countries. Treatment is still suboptimal. Dosage of urate-lowering therapy is often too low to reach target urate levels, and adherence
Externí odkaz:
https://doaj.org/article/b39455ee6890481a899e41d7efd634eb
Publikováno v:
Медицинская иммунология, Vol 13, Iss 2-3, Pp 285-290 (2014)
Abstract. Present study concerned in vitro modifying effects of mevastatin, infliximab, r-met-Hu-sTNF-RI and IL-1ra upon antigen-induced activation of peripheral EBV-specific CD4+T-lymphocytes from the patients with rheumatoid arthritis (RA). When co
Externí odkaz:
https://doaj.org/article/33b04b8675be44efab2fb398a6784976
Autor:
C A, Dinarello
Publikováno v:
Cytokine & Growth Factor Reviews. 8:253-265
Interleukin-1 (IL-1) is the prototypic pro-inflammatory cytokine. There are two forms of IL-1, IL-1alpha and IL-1beta and in most studies, their biological activities are indistinguishable. IL-1 affects nearly every cell type, often in concert with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::58bfdd6fbc9c38aaddcafa4529dc8be3
https://doi.org/10.1016/s1359-6101(97)00023-3
https://doi.org/10.1016/s1359-6101(97)00023-3
Autor:
H Mühl, C A Dinarello
Publikováno v:
The Journal of Immunology. 159:5063-5069
The release of chemokines such as macrophage-inflammatory protein-1 alpha (MIP-1 alpha) from activated macrophages is a crucial step in cell recruitment necessary for establishing local inflammatory responses. To ascertain the importance of the L-arg
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::48bc13917d1eef35fd0afe07d614a21a
https://doi.org/10.4049/jimmunol.159.10.5063
https://doi.org/10.4049/jimmunol.159.10.5063
Autor:
Katarina Alheim, C. A. Dinarello, P. Ghezzi, E. Di Santo, Homa Hasanvan, Zhen Chai, Tamas Bartfai, David Malinowsky, Giamila Fantuzzi
Publikováno v:
Proceedings of the National Academy of Sciences. 94:2681-2686
IL-1beta is an endogenous pyrogen that is induced during systemic lipopolysaccharide (LPS)- or IL-1-induced fever. We have examined the fever and cytokine responses following i.p. injection of IL-1 agonists, IL-1alpha and IL-1beta, and compared these
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e57918a099311243f02e9edb2588a61
https://doi.org/10.1073/pnas.94.6.2681
https://doi.org/10.1073/pnas.94.6.2681
Publikováno v:
The Journal of Immunology. 158:1818-1824
IL-1 beta-converting enzyme (ICE) cleaves pro-IL-1 beta to the mature, released form. Although other proteases can process pro-IL-1 beta, ICE-deficient (ICE -/-) mice do not release mature IL-1 beta in response to endotoxin. The purpose of our study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5cb860740167484311356200badbfcc4
https://doi.org/10.4049/jimmunol.158.4.1818
https://doi.org/10.4049/jimmunol.158.4.1818
Publikováno v:
The Journal of Immunology. 156:3455-3460
The complement activation products C3a and C3a desArg are generated in the course of trauma, infection, tissue injury, and ischemia. We have investigated the effects of C3a and C3a desArg on gene expression and protein synthesis of TNF-alpha and IL-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ba78800fcb1c52b7950d95e1bde66aff
https://doi.org/10.4049/jimmunol.156.9.3455
https://doi.org/10.4049/jimmunol.156.9.3455
Autor:
A E Chernoff, E V Granowitz, L Shapiro, E Vannier, G Lonnemann, J B Angel, J S Kennedy, A R Rabson, S M Wolff, C A Dinarello
Publikováno v:
The Journal of Immunology. 154:5492-5499
In vitro, IL-10 inhibits T cell proliferation and LPS-induced monocyte production of IL-1, TNF-alpha, IL-6, and IL-8. We studied the safety and immunomodulatory effects of IL-10 administration in humans. Seventeen healthy volunteers received a single
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a657fe386d8ae24f2c472b348ccb427e
https://doi.org/10.4049/jimmunol.154.10.5492
https://doi.org/10.4049/jimmunol.154.10.5492