Zobrazeno 1 - 10
of 19
pro vyhledávání: '"C. A. Broomfield"'
Publikováno v:
Toxicological Sciences. 16:267-274
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::423f94c94a360a94305781471d9397d5
https://doi.org/10.1093/toxsci/16.2.267
https://doi.org/10.1093/toxsci/16.2.267
Publikováno v:
Cell biology and toxicology. 18(3)
The toxicity of the chemical warfare blistering agent sulfur mustard (2,2'-dichlorodiethyl sulfide; SM) has been investigated for nearly a century; however, the toxicological mechanisms of SM remain obscure and no antidote exists. The similarity of d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e45f8bc45a8fcf246f786ec3e6f345df
https://pubmed.ncbi.nlm.nih.gov/12083423
https://pubmed.ncbi.nlm.nih.gov/12083423
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 299(2)
The possibility that organophosphate toxicity is due to inhibition of targets other than acetylcholinesterase (AChE, EC 3.1.1.7) was examined in AChE knockout mice. Mice (34-55 days old) were grouped for this study, after it was determined that AChE,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::78165ccd4bcb314a39c9a9d89591832c
https://pubmed.ncbi.nlm.nih.gov/11602663
https://pubmed.ncbi.nlm.nih.gov/11602663
Publikováno v:
Journal of applied toxicology : JAT. 20
Sulfur mustard (HD)-increased proteolytic activity, HD-enhanced expression of Fc receptor (FcR) on human epidermal keratinocytes (HEK) and associated inflammatory responses may contribute to HD pathology. Like the FcR, the first component of the clas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e90c68b2365474c9ef2e3b9d13707aef
https://pubmed.ncbi.nlm.nih.gov/11428648
https://pubmed.ncbi.nlm.nih.gov/11428648
Publikováno v:
Journal of applied toxicology : JAT. 20
Cytokines play a major role in both acute and chronic inflammatory processes, including those produced by sulfur mustard (2,2'-dichlorodiethyl sulfide, HD). This study describes responses of normal human epidermal keratinocytes (NHEK) to HD, defined
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0bc19c276dd74a8e6afd80f652602b62
https://pubmed.ncbi.nlm.nih.gov/11428645
https://pubmed.ncbi.nlm.nih.gov/11428645
Publikováno v:
Cell biology and toxicology. 14(4)
Sulfur mustard (HD) is a chemical warfare blister agent. The biochemical basis of HD-induced vesication is unknown, and no antidote currently exists. Basal epidermal cells are a major site of HD toxicity in vivo, with inflammation and HD-increased pr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::24904940414cfbf473067333898e1c89
https://pubmed.ncbi.nlm.nih.gov/9733281
https://pubmed.ncbi.nlm.nih.gov/9733281
Autor:
C N, Lieske, C R, Clark, L D, Zoeffel, R L, von Tersch, J R, Lowe, C D, Smith, C A, Broomfield, S I, Baskin, D M, Maxwell
Publikováno v:
Journal of applied toxicology : JAT. 16(2)
As part of our studies directed at new treatments for cyanide poisoning we examined the effect of temperature on both the non-catalyzed and the albumin-catalyzed reactions of cyanide with a colloidal suspension of elemental sulfur (CSES). Using satur
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::60a544b918b40c2fcfbcdff031866694
https://pubmed.ncbi.nlm.nih.gov/8935794
https://pubmed.ncbi.nlm.nih.gov/8935794
Publikováno v:
Journal of applied toxicology : JAT. 16(1)
The neurotoxicity of organophosphorus (OP) compounds involves the inhibition of acetylcholinesterase (AChE), causing accumulation of acetylcholine (ACh) at synapses. However, cholinergic crisis may not be the sole mechanism of OP toxicity. Adverse dr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::cc7bc001f86c9ba923958ba3f75f301d
https://pubmed.ncbi.nlm.nih.gov/8821672
https://pubmed.ncbi.nlm.nih.gov/8821672
Publikováno v:
The Journal of pharmacology and experimental therapeutics. 259(2)
Butyrylcholinesterase (BuChE) was examined as an in vivo exogenous scavenger for highly toxic organophosphorus (OP) poisons. Protection studies with equine BuChE were carried out in rhesus monkeys trained to perform a Serial Probe Recognition task. T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f8c982f64914c0e5d37e22ff87b65cc6
https://pubmed.ncbi.nlm.nih.gov/1941611
https://pubmed.ncbi.nlm.nih.gov/1941611
Publikováno v:
Cell biology and toxicology. 7(3)
Sulfur mustard is a chemical warfare blistering agent for which neither the mechanism of action nor an antidote is known. Papirmeister et al. (1985) have postulated a biochemical hypothesis for mustard-induced cutaneous injury involving a sequelae of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::4545d2f2977ae3af5dca4f767a4cfdb2
https://pubmed.ncbi.nlm.nih.gov/1933515
https://pubmed.ncbi.nlm.nih.gov/1933515