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Akademický článek

Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer

Autor: Fangyuan Chen, Sayali Onkar, Jian Zou, Yujia Li, Haley Arbore, Sai Maley, George Tseng, Peter C. Lucas, Tullia C. Bruno, Dario A. A. Vignali, Julia Foldi, Marija Balic, Adrian V. Lee, Steffi Oesterreich

Publikováno v: npj Precision Oncology, Vol 8, Iss 1, Pp 1-8 (2024)

Abstract Understanding interplay of breast cancer and microenvironment is critical. Here we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER + /HER2- ILCs. We foun

Externí odkaz: https://doaj.org/article/d4da41a6279a4b2885431e2cdb9cc697

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Akademický článek

iGenSig-Rx: an integral genomic signature based white-box tool for modeling cancer therapeutic responses using multi-omics data

Autor: Sanghoon Lee, Min Sun, Yiheng Hu, Yue Wang, Md N. Islam, David Goerlitz, Peter C. Lucas, Adrian V. Lee, Sandra M. Swain, Gong Tang, Xiao-Song Wang

Publikováno v: BMC Bioinformatics, Vol 25, Iss 1, Pp 1-17 (2024)

Abstract Multi-omics sequencing is poised to revolutionize clinical care in the coming decade. However, there is a lack of effective and interpretable genome-wide modeling methods for the rational selection of patients for personalized interventions.

Externí odkaz: https://doaj.org/article/e9e5092c3b654f949089fcaec042ef9f

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Akademický článek

Cytomegalovirus drives Vδ1+ γδ T cell expansion and clonality in common variable immunodeficiency

Autor: Samantha Chan, Benjamin Morgan, Michelle K. Yong, Mai Margetts, Anthony J. Farchione, Erin C. Lucas, Jack Godsell, Nhi Ai Giang, Charlotte A. Slade, Anouk von Borstel, Vanessa L. Bryant, Lauren J. Howson

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)

Abstract The function and phenotype of γδ T cells in the context of common variable immunodeficiency (CVID) has not been explored. CVID is a primary immunodeficiency disorder characterized by impaired antibody responses resulting in increased susce

Externí odkaz: https://doaj.org/article/5b30bc08f2604b69846f6ba0bb2d8815

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Akademický článek

Generative artificial intelligence (Gen-AI) in pharmacy education: Utilization and implications for academic integrity: A scoping review

Autor: R. Mortlock, C. Lucas

Publikováno v: Exploratory Research in Clinical and Social Pharmacy, Vol 15, Iss , Pp 100481- (2024)

Introduction: Generative artificial intelligence (Gen-AI), exemplified by the widely adopted ChatGPT, has garnered significant attention in recent years. Its application spans various health education domains, including pharmacy, where its potential

Externí odkaz: https://doaj.org/article/ac4d17be8a664ad9ad739df7c9cbdafc

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Akademický článek

NSABP FB-10: a phase Ib/II trial evaluating ado-trastuzumab emtansine (T-DM1) with neratinib in women with metastatic HER2-positive breast cancer

Publikováno v: Breast Cancer Research, Vol 26, Iss 1, Pp 1-13 (2024)

Abstract Background We previously reported our phase Ib trial, testing the safety, tolerability, and efficacy of T-DM1 + neratinib in HER2-positive metastatic breast cancer patients. Patients with ERBB2 amplification in ctDNA had deeper and more dura

Externí odkaz: https://doaj.org/article/c30874be81f04b78be67858f937fdb82

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Akademický článek

Eliminando el concepto de enfermedad renal crónica no filiada: a propósito de 2 casos de nefropatía túbulo-intersticial autosómica dominante con variante patogénica MUC-1

Autor: V. Barcia, E. Monfá, B. de León, C. Martinez-Rosero, S. Sánchez-Montero, C. Barnes, C. Lucas, A. Sastre, J. Estifan, M. Prieto

Publikováno v: Nefrología, Vol 44, Iss 1, Pp 105-107 (2024)

Externí odkaz: https://doaj.org/article/897433bdf5994bb7976e96aef0964f66

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Akademický článek

Spatially resolved generation profiles for building, land and water-bound PV: a case study of four Dutch energy transition scenarios

Autor: N. Nortier, M. Paardekooper, C. Lucas, A. Blankert, A. van der Neut, S. Luxembourg, A. Mewe, W. van Sark

Publikováno v: Advances in Geosciences, Vol 58, Pp 199-216 (2023)

Alongside a transition from steerable and centralized traditional electricity generation to intermittent and more decentralized renewable electricity generation from solar panels and wind turbines, Dutch energy transition scenarios project a widespre

Externí odkaz: https://doaj.org/article/96f9202a71ff46c4a969891cdd991039

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