Zobrazeno 1 - 9
of 9
pro vyhledávání: '"C. Brent Putman"'
Autor:
Adrian D. Hobson, Russell A. Judge, Ana L. Aguirre, Brian S. Brown, Yifang Cui, Ping Ding, Eric Dominguez, Enrico DiGiammarino, David A. Egan, Gail M. Freiberg, Sujatha M. Gopalakrishnan, Christopher M. Harris, Marie P. Honore, Karen L. Kage, Nicolas J. Kapecki, Christopher Ling, Junli Ma, Helmut Mack, Mulugeta Mamo, Stefan Maurus, Bradford McRae, Nigel S. Moore, Bernhard K. Mueller, Reinhold Mueller, Marian T. Namovic, Kaushal Patel, Steve D. Pratt, C. Brent Putman, Kara L. Queeney, Kathy K. Sarris, Lisa M. Schaffter, Vincent Stoll, Anil Vasudevan, Lei Wang, Lu Wang, William Wirthl, Kimberly Yach
Publikováno v:
Journal of Medicinal Chemistry. 61:11074-11100
A HTS campaign identified compound 1, an excellent hit-like molecule to initiate medicinal chemistry efforts to optimize a dual ROCK1 and ROCK2 inhibitor. Substitution (2-Cl, 2-NH
Autor:
Victoria E. Scott, Mulugeta Mamo, Russell A. Judge, Connie R. Faltynek, C. Brent Putman, Ana L. Aguirre, Marian Namovic, Vincent S. Stoll, Karen Kage, Steven Cassar, Adrian D. Hobson, Janel M. Boyce-Rustay, Steve D. Pratt, Anil Vasudevan, Steven Swann, Gricelda H. Simler
Publikováno v:
ChemBioChem. 19:613-621
We describe the design, synthesis, and structure-activity relationships (SARs) of a series of 2-aminobenzothiazole inhibitors of Rho kinases (ROCKs) 1 and 2, which were optimized to low nanomolar potencies by use of protein kinase A (PKA) as a struct
Autor:
James T. Limberis, Di Zhang, Torben R. Neelands, Richard S. Janis, Diana L. Donnelly-Roberts, Wende Niforatos, Timothy A. Vortherms, Carol S. Surowy, C. Brent Putman, Ruth L. Martin, Michael F. Jarvis, Marian T. Namovic, Rama Thimmapaya, Andrew M. Swensen, Victoria E. Scott
Publikováno v:
Inflammation Research. 60:683-693
The aim of this study was to compare a diverse set of peptide and small-molecule calcium channel blockers for inactivated-state block of native and recombinant N-type calcium channels using fluorescence-based and automated patch-clamp electrophysiolo
Autor:
Russell A. Judge, Anil Vasudevan, Victoria E. Scott, Gricelda H. Simler, Steve D. Pratt, Marian T. Namovic, C. Brent Putman, Ana Aguirre, Vincent S. Stoll, Mulugeta Mamo, Steven I. Swann, Steven C. Cassar, Connie R. Faltynek, Karen L. Kage, Janel M. Boyce-Rustay, Adrian D. Hobson
Publikováno v:
ChemBioChem. 19:890-890
Autor:
Clark A. Briggs, Carol S. Surowy, Michael J. Marks, Rama Thimmapaya, C. Brent Putman, Michael Meyer, Earl J. Gubbins
Publikováno v:
Molecular Pharmacology. 70:227-240
alpha4beta2 nicotinic acetylcholine receptors (nAChRs) are recognized as the principal nicotine binding site in brain. Recombinant alpha4beta2 nAChR demonstrate biphasic concentration-response relationships with low- and high-EC50 components. This st
Autor:
Clark A, Briggs, Earl J, Gubbins, C Brent, Putman, Rama, Thimmapaya, Michael D, Meyer, Carol S, Surowy
Publikováno v:
Journal of molecular neuroscience : MN. 30(1-2)
Previous studies in other laboratories have shown that alpha4beta2 nicotinic acetylcholine receptor (nAChR) exhibits a biphasic concentration-response relationship for ACh with low and high EC50 components, and that the low EC50 component can be augm
Autor:
C. Brent Putman, Michael Meyer, Earl J. Gubbins, Clark A. Briggs, Carol S. Surowy, Rama Thimmapaya
Publikováno v:
Journal of Molecular Neuroscience. 30:11-12
Previous studies in other laboratories have shown that alpha4beta2 nicotinic acetylcholine receptor (nAChR) exhibits a biphasic concentration-response relationship for ACh with low and high EC50 components, and that the low EC50 component can be augm
Autor:
William H. Bunnelle, Jerome F. Daanen, Keith B. Ryther, Michael R. Schrimpf, Michael J. Dart, Arianna Gelain, Michael D. Meyer, Jennifer M. Frost, David J. Anderson, Michael Buckley, Peter Curzon, Ying-Jun Cao, Pamela Puttfarcken, Xenia Searle, Jianguo Ji, C. Brent Putman, Carol Surowy, Lucio Toma, Daniela Barlocco
Publikováno v:
Journal of Medicinal Chemistry; Jul2007, Vol. 50 Issue 15, p3627-3644, 18p
Autor:
Vortherms TA; Neuroscience Research, Global Pharmaceutical Research and Development, Abbott Laboratories, Dept R4PM, Bldg. AP9A, 100 Abbott Park Road, Abbott Park, IL 60064-6125, USA. timothy.vortherms@abbott.com, Swensen AM, Niforatos W, Limberis JT, Neelands TR, Janis RS, Thimmapaya R, Donnelly-Roberts DL, Namovic MT, Zhang D, Brent Putman C, Martin RL, Surowy CS, Jarvis MF, Scott VE
Publikováno v:
Inflammation research : official journal of the European Histamine Research Society ... [et al.] [Inflamm Res] 2011 Jul; Vol. 60 (7), pp. 683-93. Date of Electronic Publication: 2011 Mar 11.