Zobrazeno 1 - 10
of 103
pro vyhledávání: '"C. Peter Downes"'
Publikováno v:
Journal of Biological Chemistry. 285:12620-12628
The PTEN (phosphatase and tensin homolog) tumor suppressor is a phosphatase that inhibits phosphoinositide 3-kinase-dependent signaling by metabolizing the phosphoinositide lipid phosphatidylinositol 3,4,5-trisphosphate (PtdInsP(3)) at the plasma mem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::960c57be6ab1c3a3614af2cdf319987a
https://doi.org/10.1074/jbc.m109.072280
https://doi.org/10.1074/jbc.m109.072280
Autor:
Laura Spinelli, Priyanka Tibarewal, Nimmi R. Weerasinghe, Nick R. Leslie, Georgios Zilidis, Joseph C. Lim, C. Peter Downes, Helene Maccario
Publikováno v:
Advances in Enzyme Regulation. 50:112-118
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40a4235aed6d6e9691fe2507399c1ba3
https://doi.org/10.1016/j.advenzreg.2009.10.015
https://doi.org/10.1016/j.advenzreg.2009.10.015
Autor:
C. Peter Downes, Madeline Parsons, Michiel T. van Diepen, Britta J. Eickholt, Robert Hindges, Nick R. Leslie
Publikováno v:
Nature cell biology
The tumour suppressor PTEN can inhibit cell proliferation and migration as well as control cell growth, in different cell types. PTEN functions predominately as a lipid phosphatase, converting PtdIns(3,4,5)P(3) to PtdIns(4,5)P(2), thereby antagonizin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903c0891f61b0414a9fef5d1d4d74a83
https://doi.org/10.1038/ncb1961
https://doi.org/10.1038/ncb1961
Publikováno v:
Journal of Biological Chemistry. 284:10571-10582
Inositol hexakisphosphate kinases (IP6Ks) phosphorylate inositol hexakisphosphate (InsP6) to yield 5-diphosphoinositol pentakisphosphate (5-[PP]-InsP5 or InsP7). In this study, we report the characterization of a selective inhibitor, N2-(m-(trifluoro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8773ebb552de716c6ca253ea43efaaa3
https://doi.org/10.1074/jbc.m900752200
https://doi.org/10.1074/jbc.m900752200
Publikováno v:
Journal of Biological Chemistry. 283:1372-1380
Influenza A virus NS1 protein stimulates host-cell phosphoinositide 3-kinase (PI3K) signaling by binding to the p85beta regulatory subunit of PI3K. Here, in an attempt to establish a mechanism for this activation, we report further on the functional
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::682e51580837fa12308be7653bcb31ca
https://doi.org/10.1074/jbc.m708862200
https://doi.org/10.1074/jbc.m708862200
Autor:
C. Peter Downes, Miles J. Dixon, Jeroen van der Kaay, Alexander Gray, Ian H. Batty, Joan F. Telfer
Publikováno v:
Biochemical Journal. 407:255-266
Activation of class Ia PI3K (phosphoinositide 3-kinase) produces PtdInsP3, a vital intracellular mediator whose degradation generates additional lipid signals. In the present study vanadate analogues that inhibit PTPs (protein tyrosine phosphatases)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec8a2165abd55f5a44e19ee62399451e
https://doi.org/10.1042/bj20070558
https://doi.org/10.1042/bj20070558
Publikováno v:
Biochemical Journal. 405:439-444
Although PTEN (phosphatase and tensin homologue deleted on chromosome 10) is one of the most commonly mutated tumour suppressors in human cancers, loss of PTEN expression in the absence of mutation appears to occur in an even greater number of tumour
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::66a7028fee2b892f4980325d318bd6e3
https://doi.org/10.1042/bj20061837
https://doi.org/10.1042/bj20061837
Autor:
Stephen T. Safrany, Michael J. Clague, Nick R. Leslie, Óscar Lorenzo, C. Peter Downes, Rachel Toth, Sarah H. Ross, Yvonne E. Lindsay, Fabrizio Villa
Publikováno v:
Cellular Signalling. 19:1521-1530
The Protein Tyrosine Phosphatase (PTP) family comprises a large and diverse group of enzymes, regulating a range of biological processes through de-phosphorylation of many proteins and lipids. These enzymes share a catalytic mechanism that requires a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4c1e44286ab1e96810a0655a017cda6d
https://doi.org/10.1016/j.cellsig.2007.01.026
https://doi.org/10.1016/j.cellsig.2007.01.026
Publikováno v:
Biochemical Society Symposia. 74:69-80
PTEN (phosphatase and tensin homologue deleted on chromosome 10) is a tumour suppressor that functions as a PtdIns(3,4,5)P3 3-phosphatase to inhibit cell proliferation, survival and growth by antagonizing PI3K (phosphoinositide 3-kinase)-dependent si
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c5ef11c46b1b083ebd6d9fe22fe01caf
https://doi.org/10.1042/bss2007c07
https://doi.org/10.1042/bss2007c07