Zobrazeno 1 - 10
of 104
pro vyhledávání: '"C., Mazzarino"'
Autor:
Guoqiang George Sun, Cheng Wang, Randall C. Mazzarino, Paula Andrea Perez-Corredor, Hayk Davtyan, Mathew Blurton-Jones, Francisco Lopera, Joseph F. Arboleda-Velasquez, Yanhong Shi
Publikováno v:
Cell Reports, Vol 43, Iss 12, Pp 114982- (2024)
Summary: Alzheimer’s disease (AD) is the most prevalent neurodegenerative disorder characterized by extracellular amyloid plaques and neuronal Tau tangles. A recent study found that the APOE3 Christchurch (APOECh) variant could delay AD progression
Externí odkaz:
https://doaj.org/article/8f3af47b909f4ff1864999f8e2ce361d
Autor:
Paula Perez-Corredor, Timothy E. Vanderleest, Guido N. Vacano, Justin S. Sanchez, Nelson D. Villalba-Moreno, Claudia Marino, Susanne Krasemann, Miguel A. Mendivil-Perez, David Aguillón, Marlene Jiménez-Del-Río, Ana Baena, Diego Sepulveda-Falla, Francisco Lopera, Yakeel T. Quiroz, Joseph F. Arboleda-Velasquez, Randall C. Mazzarino
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 17 (2024)
A patient with the PSEN1 E280A mutation and homozygous for APOE3 Christchurch (APOE3Ch) displayed extreme resistance to Alzheimer’s disease (AD) cognitive decline and tauopathy, despite having a high amyloid burden. To further investigate the diffe
Externí odkaz:
https://doaj.org/article/5a75deb4bb57460d9fea9624ee74d0f7
Autor:
Francisco Lopera, Claudia Marino, Anita S. Chandrahas, Michael O’Hare, Nelson David Villalba-Moreno, David Aguillon, Ana Baena, Justin S. Sanchez, Clara Vila-Castelar, Liliana Ramirez Gomez, Natalia Chmielewska, Gabriel M. Oliveira, Jessica Lisa Littau, Kristin Hartmann, Kyungeun Park, Susanne Krasemann, Markus Glatzel, Dorothee Schoemaker, Lucia Gonzalez-Buendia, Santiago Delgado-Tirado, Said Arevalo-Alquichire, Kahira L. Saez-Torres, Dhanesh Amarnani, Leo A. Kim, Randall C. Mazzarino, Harper Gordon, Yamile Bocanegra, Andres Villegas, Xiaowu Gai, Moiz Bootwalla, Jianling Ji, Lishuang Shen, Kenneth S. Kosik, Yi Su, Yinghua Chen, Aaron Schultz, Reisa A. Sperling, Keith Johnson, Eric M. Reiman, Diego Sepulveda-Falla, Joseph F. Arboleda-Velasquez, Yakeel T. Quiroz
Publikováno v:
Nature Medicine. 29:1243-1252
We characterized the world’s second case with ascertained extreme resilience to autosomal dominant Alzheimer’s disease (ADAD). Side-by-side comparisons of this male case and the previously reported female case with ADAD homozygote for the APOE3 C
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cbe347616c0af69e09ef1427cfb6ea9e
https://doi.org/10.1038/s41591-023-02318-3
https://doi.org/10.1038/s41591-023-02318-3
Autor:
Randall C. Mazzarino
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
We are currently experiencing a deadly novel viral pandemic with no efficacious, readily available anti-viral therapies to SARS-CoV-2. Viruses will hijack host cellular machinery, including metabolic processes. Here, I provide theory and evidence for
Externí odkaz:
https://doaj.org/article/bf8c61600dba4833b1a3c48e59c265ad
Publikováno v:
European Psychiatry, Vol 64, Pp S335-S335 (2021)
Introduction According to the World Health Organization (WHO, 2017) depressive disorder continues to be the most widespread and growing mental illness in the world, also assumes that in 2020 depression will have a prevalence equal to one in six indiv
Externí odkaz:
https://doaj.org/article/3e2ad3fe50a64736a485a7d1b0c6d791
Autor:
Randall C Mazzarino, Veronika Baresova, Marie Zikánová, Nathan Duval, Terry G Wilkinson, David Patterson, Guido N Vacano
Publikováno v:
PLoS ONE, Vol 16, Iss 7, p e0247227 (2021)
In humans, GART [phosphoribosylglycinamide formyltransferase (EC 2.1.2.2) / phosphoribosylglycinamide synthetase (EC 6.3.4.13) / phosphoribosylaminoimidazole synthetase (EC 6.3.3.1)] is a trifunctional protein which catalyzes the second, third, and f
Externí odkaz:
https://doaj.org/article/54ef6066cb6c430fa7cef10f019684ac
Autor:
Randall C. Mazzarino, Veronika Baresova, Marie Zikánová, Nathan Duval, Terry G. Wilkinson, II, David Patterson, Guido N. Vacano
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 25, Iss , Pp 100642- (2020)
In de novo purine biosynthesis (DNPS), 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase (EC 2.1.2.3)/inosine monophosphate cyclohydrolase (EC 3.5.4.10) (ATIC) catalyzes the last two reactions of the pathway: conversion of 5-aminoimidaz
Externí odkaz:
https://doaj.org/article/9d371210153f41a2a86d1a26c04d6739
Autor:
Randall C. Mazzarino, Veronika Baresova, Marie Zikánová, Nathan Duval, Terry G. Wilkinson, II, David Patterson, Guido N. Vacano
Publikováno v:
Molecular Genetics and Metabolism Reports, Vol 21, Iss , Pp - (2019)
Adenylosuccinate lyase (ADSL) catalyzes two steps in de novo purine synthesis (DNPS). Mutations in ADSL can result in inborn errors of metabolism characterized by developmental delay and disorder phenotypes, with no effective treatment options. Recen
Externí odkaz:
https://doaj.org/article/888860c192834a11b698b87f3b09b951
Autor:
Massimo Libra, Silvana Canevari, Franca Stivala, Salvatore Travali, Pietro Gangemi, Francesco Marchese, Mariangela Figini, Maria C. Mazzarino, Grazia Malaponte, Giancarlo Castellano
Purpose: Prostate cancer remains the second most frequent cause of tumor-related deaths in the Western world. Additional markers for the identification of prostate cancer development and progression are needed. Osteopontin (OPN), which activates matr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dfcd7a1df853f84c42b7eb242a16c77
https://doi.org/10.1158/1078-0432.c.6517251
https://doi.org/10.1158/1078-0432.c.6517251
Autor:
Massimo Libra, Silvana Canevari, Franca Stivala, Salvatore Travali, Pietro Gangemi, Francesco Marchese, Mariangela Figini, Maria C. Mazzarino, Grazia Malaponte, Giancarlo Castellano
Supplementary Data from Activation of the Osteopontin/Matrix Metalloproteinase-9 Pathway Correlates with Prostate Cancer Progression
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::46a8414d6559d572f8d9c09e7c2dba45
https://doi.org/10.1158/1078-0432.22439844
https://doi.org/10.1158/1078-0432.22439844