Zobrazeno 1 - 10
of 78
pro vyhledávání: '"C-myc Genes"'
Autor:
Weiwei Zhang, Jianhang Yin, Jiazhi Hu, Changchang Xin, Zhengrong Zhang-Ding, Chen Ai, Yuhong Wang, Mengzhu Liu
Publikováno v:
Nucleic Acids Research
A series of Cas9 variants have been developed to improve the editing fidelity or targeting range of CRISPR–Cas9. Here, we employ a high-throughput sequencing approach primer-extension-mediated sequencing to analyze the editing efficiency, specifici
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7073c536e884b52e2a3781ea60ec5f41
https://doi.org/10.1093/nar/gkab507
https://doi.org/10.1093/nar/gkab507
Autor:
Kun-Liang Guan, Zongbing You, Shaoqiong Chen, Denis C. Guttridge, Cun-Yu Wang, Anthony M. C. Brown, Ormond A. MacDougald, Zhaocheng Zhang, Gerard I. Evan, Daniel Saims, Jan Kitajewski
Publikováno v:
The Journal of Cell Biology
Aberrant activation of the Wnt/β-catenin signaling pathway is associated with numerous human cancers and often correlates with the overexpression or amplification of the c-myc oncogene. Paradoxical to the cellular transformation potential of c-Myc i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ce0589bff885b8202f8b0e8c2bc932e
https://doi.org/10.1083/jcb.20020111004052021c
https://doi.org/10.1083/jcb.20020111004052021c
Autor:
Snehasish Bhattacharjee, Rajendra Kumar, Sudipta Bhowmik, Rabindra Nath Das, Mattias Hedenström, Erik Chorell, Karam Chand
Publikováno v:
Nucleic Acids Research
G-quadruplex (G4) DNA structures are linked to key biological processes and human diseases. Small molecules that target specific G4 DNA structures and signal their presence would therefore be of great value as chemical research tools with potential t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cbf7054d94398bb9bac3b61e124c549b
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168878
http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-168878
Autor:
Luca Tiberi
Publikováno v:
Neuro-Oncology. 23:vi220-vi220
Among children/infant brain tumors, Medulloblastoma (MB) is the most common and stands as a cause for a high percentage of morbidity and mortality among patients During the past few years, studies on human MB have uncovered the existence of four majo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9d7f7f7686b60f963edc73eea6c39871
https://doi.org/10.1093/neuonc/noab196.884
https://doi.org/10.1093/neuonc/noab196.884
Autor:
Sara Morrow, Joshua E. Allen, Ultan McDermott, Cyril H. Benes, Mathew J. Garnett, Varun V. Prabhu
Publikováno v:
Neuro Oncol
ONC206 is a DRD2 antagonist and ClpP agonist that is a chemical derivative of ONC201, which is in Phase II clinical trials for H3 K27M-mutant glioma. We have previously reported that dopamine receptor expression correlates with ONC201 and ONC206 effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56cc16d8002a00213e667cb4f07ff351
https://doi.org/10.1093/neuonc/noaa215.057
https://doi.org/10.1093/neuonc/noaa215.057
Autor:
Krishna Madhavan, Rajeev Vibhakar, Angela Pierce, Susan Fosmire, Sujatha Venkataraman, Dong Wang, Bethany Veo
Myc-driven Medulloblastoma remains a major therapeutic challenge due to frequent metastasis and a poor 5-year survival rate. Myc overexpression results in transcriptional dysregulation, proliferation, and survival of malignant cells. However direct i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::438aea488dfac528fd66218a7475c2f6
https://europepmc.org/articles/PMC6477310/
https://europepmc.org/articles/PMC6477310/
Brain cancer is now the deadliest form of childhood cancer in the United States. In particular, Group3 Medulloblastoma (MB) is the pediatric brain tumor with the highest morbidity and mortality. Patients with Group3 MB currently have the worst outcom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3420d9654495c35beda64de071f54f59
https://europepmc.org/articles/PMC6477399/
https://europepmc.org/articles/PMC6477399/
Autor:
Sujatha Venkataraman, Angela Pierce, Irina Alimova, Diane Birks, Min Yang, Hinning Ling, Nicholas K. Foreman, Rajeev Vibhakar
Atypical Teratoid Rhabdoid Tumor (ATRT) is a highly aggressive and malignant pediatric brain tumor with poor outcomes. The central mechanism of ATRT tumorigenesis is SMARCB1 deficiency that leads to epigenetic dysregulation. To identify key epigeneti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::418385d467d2ee0e02c933832fe0df31
https://europepmc.org/articles/PMC6012123/
https://europepmc.org/articles/PMC6012123/
Autor:
Elizabeth Chun, M Kool, Elizabeth J. Perlman, Murat Iskar, Serap Erkek, Pascal Johann, Stefan M. Pfister, Marco A. Marra, Martin Hasselblatt
Rhabdoid tumors (RTs) are pediatric cancers that account for nearly 10% of all tumors in infants. Currently, RTs are classified according to tumor location. In the central nervous system, they are called atypical teratoid/rhabdoid tumors (ATRTs) as c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a3224f49293cfa8d1612669a4dcbf40c
https://europepmc.org/articles/PMC6012019/
https://europepmc.org/articles/PMC6012019/
Autor:
Yiru Zhang, Varun V. Prabhu, Mike-Andrew Westhoff, Markus D. Siegelin, Georg Karpel-Massler, Joshua E. Allen, Chiaki Tsuge Ishida
Publikováno v:
Neuro-Oncology. 20:vi98-vi99
The purpose of this study is to improve the efficacy of imipridones, a novel class of AKT/ERK inhibitors. The lead compound ONC201 has entered clinical testing for glioblastoma (GBM) and recently chemically modified imipridones, ONC206 and ONC212, ha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::227982376506f07e1ad2057e9e691d45
https://doi.org/10.1093/neuonc/noy148.411
https://doi.org/10.1093/neuonc/noy148.411