Cruzipain Sulfotopes-Specific Antibodies Generate Cardiac Tissue Abnormalities and Favor Trypanosoma cruzi Infection in the BALB/c Mice Model of Experimental Chagas Disease

Autor: Luciana L. Soprano, Maximiliano R. Ferrero, Malena Landoni, Gabriela A. García, Mónica I. Esteva, Alicia S. Couto, Vilma G. Duschak

Publikováno v: Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)

Trypanosoma cruzi cruzipain (Cz) bears a C-terminal domain (C-T) that contains sulfated epitopes “sulfotopes” (GlcNAc6S) on its unique N-glycosylation site. The effects of in vivo exposure to GlcNAc6S on heart tissue ultrastructure, immune respon

Externí odkaz: https://doaj.org/article/45739db653b84dc99a59139195ffe308

Sulfates are main targets of immune responses to cruzipain and are involved in heart damage in BALB/c immunized mice

Autor: Acosta, D.M., Arnaiz, M.R., Esteva, M.I., Barboza, M., Stivale, D., Orlando, U.D., Torres, S., Laucella, S.A., Couto, A.S., Duschak, V.G.

Publikováno v: Int. Immunol. 2008;20(4):461-470
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Trypanosoma cruzi, the agent of Chagas disease contains a major cysteine proteinase, cruzipain (Cz), with an unusual carboxyl-terminal extension (C-T). We have previously reported the presence of sulfate groups in the N-linked oligosaccharide chains

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=od______3056::5e468d0debfe60228d4d7de981780fab