Combining the AKT inhibitor capivasertib and SERD fulvestrant is effective in palbociclib-resistant ER+ breast cancer preclinical models

Autor: Lorna Hopcroft, Eleanor M. Wigmore, Stuart C. Williamson, Susana Ros, Cath Eberlein, Jennifer I. Moss, Jelena Urosevic, Larissa S. Carnevalli, Sara Talbot, Lauren Bradshaw, Catherine Blaker, Sreeharsha Gunda, Venetia Owenson, Scott Hoffmann, Daniel Sutton, Stewart Jones, Richard J. A. Goodwin, Brandon S. Willis, Claire Rooney, Elza C. de Bruin, Simon T. Barry

Publikováno v: npj Breast Cancer, Vol 9, Iss 1, Pp 1-14 (2023)

Abstract Combining the selective AKT inhibitor, capivasertib, and SERD, fulvestrant improved PFS in a Phase III clinical trial (CAPItello-291), treating HR+ breast cancer patients following aromatase inhibitors, with or without CDK4/6 inhibitors. How

Externí odkaz: https://doaj.org/article/216706db2e6b4b6eae15d98244910c27

Concomitant KRAS mutations attenuate sensitivity of non-small cell lung cancer cells to KRAS G12C inhibition

Autor: Tereza Vaclova, Atanu Chakraborty, James Sherwood, Sarah Ross, Danielle Carroll, J. Carl Barrett, Julian Downward, Elza C. de Bruin

Publikováno v: Scientific Reports, Vol 12, Iss 1, Pp 1-9 (2022)

Abstract The development of covalent inhibitors against KRAS G12C represents a major milestone in treatment of RAS-driven cancers, especially in non-small cell lung cancer (NSCLC), where KRAS G12C is one of the most common oncogenic driver. Here we i

Externí odkaz: https://doaj.org/article/80183fd1fcb54089bce08329d47a9691

Human total, basal and activity energy expenditures are independent of ambient environmental temperature

Autor: Xueying Zhang, Yosuke Yamada, Hiroyuki Sagayama, Philip N. Ainslie, Ellen E. Blaak, Maciej S. Buchowski, Graeme L. Close, Jamie A. Cooper, Sai Krupa Das, Lara R. Dugas, Michael Gurven, Asmaa El Hamdouchi, Sumei Hu, Noorjehan Joonas, Peter Katzmarzyk, William E. Kraus, Robert F. Kushner, William R. Leonard, Corby K. Martin, Erwin P. Meijer, Marian L. Neuhouser, Robert M. Ojiambo, Yannis P. Pitsiladis, Guy Plasqui, Ross L. Prentice, Susan B. Racette, Eric Ravussin, Leanne M. Redman, Rebecca M. Reynolds, Susan B. Roberts, Luis B. Sardinha, Analiza M. Silva, Eric Stice, Samuel S. Urlacher, Edgar A. Van Mil, Brian M. Wood, Alexia J. Murphy-Alford, Cornelia Loechl, Amy H. Luke, Jennifer Rood, Dale A. Schoeller, Klaas R. Westerterp, William W. Wong, Herman Pontzer, John R. Speakman, Lene F. Andersen, Liam J. Anderson, Lenore Arab, Issad Baddou, Bedu Addo, Stephane Blanc, Alberto Bonomi, Carlijn V.C. Bouten, Pascal Bovet, Stefan Branth, Niels C. De Bruin, Nancy F. Butte, Lisa H. Colbert, Stephan G. Camps, Alice E. Dutman, Simon D. Eaton, Ulf Ekelund, Sonja Entringer, Cara Ebbeling, Sölve Elmståhl, Mikael Fogelholm, Terrence Forrester, Barry W. Fudge, Tamara Harris, Rik Heijligenberg, Annelies H. Goris, Catherine Hambly, Marije B. Hoos, Hans U. Jorgensen, Annemiek M. Joosen, Kitty P. Kempen, Misaka Kimura, Watanee Kriengsinyos, Estelle V. Lambert, Christel L. Larsson, Nader Lessan, David S. Ludwig, Margaret McCloskey, Anine C. Medin, Gerwin A. Meijer, Eric Matsiko, Alida Melse-Boonstra, James C. Morehen, James P. Morton, Theresa A. Nicklas, Daphne L. Pannemans, Kirsi H. Pietiläinen, Renaat M. Philippaerts, Roberto A. Rabinovich, John J. Reilly, Elisabet M. Rothenberg, Albertine J. Schuit, Sabine Schulz, Anders M. Sjödin, Amy Subar, Minna Tanskanen, Ricardo Uauy, Giulio Valenti, Ludo M. Van Etten, Rita Van den Berg-Emons, Wim G. Van Gemert, Erica J. Velthuis-te Wierik, Wilhelmine W. Verboeket-van de Venne, Jeanine A. Verbunt, Jonathan C.K. Wells, George Wilson

Publikováno v: iScience, Vol 25, Iss 8, Pp 104682- (2022)

Summary: Lower ambient temperature (Ta) requires greater energy expenditure to sustain body temperature. However, effects of Ta on human energetics may be buffered by environmental modification and behavioral compensation. We used the IAEA DLW databa

Externí odkaz: https://doaj.org/article/185d20235c154c7c8514e8e72ad6ab8c

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

Autor: Tereza Vaclova, Ursula Grazini, Lewis Ward, Daniel O’Neill, Aleksandra Markovets, Xiangning Huang, Juliann Chmielecki, Ryan Hartmaier, Kenneth S. Thress, Paul D. Smith, J. Carl Barrett, Julian Downward, Elza C. de Bruin

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)

A recent clinical trial shows that a proportion of lung cancer patients carrying the EGFR T790M mutation develop resistance to osimertinib. In this study, the authors show that T790M subclonality is associated with worse clinical outcome likely throu

Externí odkaz: https://doaj.org/article/481ad63fcd374f3eb7bb421d24c7891e

Editorial: self-illness ambiguity and narrative identity

Autor: Roy Dings, Léon C. De Bruin

Publikováno v: Philosophical Explorations. 26:147-154

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::742bdba8ed5267e5fa01a22449c0bf9e
https://doi.org/10.1080/13869795.2023.2203709