Phase II study of XR5000 (DACA) administered as a 120-h infusion in patients with recurrent glioblastoma multiforme

Autor: Pierre Fumoleau, Mario Campone, Chris Twelves, Denis Lacombe, M. J. van den Bent, Roy Rampling, Bruno Coudert, C. de Balincourt, M.J.A. de Jonge, C. Dittrich, Roberto Sorio

Publikováno v: Annals of Oncology, 13, 777-780. Elsevier Ltd.

Background XR5000 is a tricyclic carboxamide that intercalates DNA and inhibits both topoisomerase I and II. The aim of this study was to evaluate the efficacy and tolerability of XR5000 in patients with recurrent glioblastoma multiforme previously u

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c2e766ef5a5e29611168d0f898a3973
https://doi.org/10.1093/annonc/mdf121

Phase II EORTC trial with 5-fluorouracil, cisplatin and interferon-α as second-line treatment of advanced transitional cell cancer of the urothelial tract

Autor: C. de Balincourt, P.H.M. de Mulder, Christine Theodore, Avishay Sella, O. Koriakine, Laurence Collette, Cora N. Sternberg

Publikováno v: Annals of Oncology. 11:1391-1394

Summary Background Based on the favorable results of the combination 5-fluorouracil (5-FU), cisplatin and interferon-α as second-line treatment in advanced metastatic transitional-cell carcinoma of the urothelial tract a confirmatory study was execu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::099d81ac007eba3c61b4c252ad2dec75
https://doi.org/10.1023/a:1026589120989

Frequency of Positive Biopsies after Visual Disappearance of Superficial Bladder Cancer Marker Lesions

Autor: R. R. Hall, Av Bono, Richard Sylvester, Doris Mack, C. de Balincourt, Willem Oosterlinck, Maurizio Brausi

Publikováno v: European Urology. 40:515-517

In phase II trials in superficial bladder cancer, marker lesions have been used to test the ablative activity of intravesical chemo- or immunotherapy. These studies provide important knowledge about drug activity and toxicity without exposing hundred

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::41502d95737ef696b76c872eaebcb214
https://doi.org/10.1159/000049828

Multicentre EORTC study 16997: feasibility and phase II trial of farnesyl transferase inhibitorgemcitabine combination in salvage treatment of advanced urothelial tract cancers

Autor: C. de Balincourt, Christine Theodore, Alain Ravaud, Lionnel Geoffrois, Jan B. Vermorken, Godefridus J. Peters, Denis Lacombe, Philippe Chollet, Pierre Fumoleau, Walter Fiedler, F Caponigro

Publikováno v: European Journal of Cancer, 41(8), 1150-1157. Pergamon
Theodore, C, Geoffrois, L, Vermorken, J B, Caponigro, F, Fiedler, W, Chollet, P, Ravaud, A, Peters, G J, de Balincourt, C, Lacombe, D & Fumoleau, P 2005, ' Multicentre EORTC study 16997: feasibility and phase II trial of farnesyl transferase inhibitor & gemcitabine combination in salvage treatment of advanced urothelial tract cancers ', European Journal of Cancer, vol. 41, no. 8, pp. 1150-1157 . https://doi.org/10.1016/j.ejca.2005.02.015
European journal of cancer

In this study, the feasibility and activity of combined chemotherapy of the farnesyl transferase inhibitor SCH66336 and gemcitabine was evaluated. This therapy was used as second-line treatment in patients with advanced urothelial tract cancer and th

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d64dcd1dd5da0c7a4730a92f8982526
https://pubmed.ncbi.nlm.nih.gov/15911238

Significance of bladder biopsies in Ta,T1 bladder tumors: a report from the EORTC Genito-Urinary Tract Cancer Cooperative Group. EORTC-GU Group Superficial Bladder Committee

Autor: A, van der Meijden, W, Oosterlinck, M, Brausi, K H, Kurth, R, Sylvester, C, de Balincourt

Publikováno v: European urology. 35(4)

We investigated to what extent biopsies of normal-appearing urothelium taken from patients with Ta,T1 bladder cancer showed malignant disease: carcinoma in situ, or papillary tumor. We also investigated biopsies underlying the papillary tumor, adjace

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::125a28f8ed347b1f2989b5a7c56cbd3d
https://pubmed.ncbi.nlm.nih.gov/10419345