Zobrazeno 1 - 6
of 6
pro vyhledávání: '"C Y Kuk"'
Autor:
N J Andersen, E A Boguslawski, A S Naidu, C Szot, J L Bromberg-White, K Kits, C Y Kuk, L E Holton, B St Croix, C M Chambers, N S Duesbery
Publikováno v:
PLoS ONE, Vol 11, Iss 1, p e0146586 (2016)
Anthrax toxin receptor 1/tumor endothelial marker 8 (Antxr1 or TEM8) is up-regulated in tumor vasculature and serves as a receptor for anthrax toxin, but its physiologic function is unclear. The objective of this study was to evaluate the role of Ant
Externí odkaz:
https://doaj.org/article/4f54ccb5071049c68b2b69d5cac37f59
Autor:
Menglan He, Alvin C. Y. Kuk, Mei Ding, Cheen Fei Chin, Dwight L.A. Galam, Jie Min Nah, Bryan C. Tan, Hui Li Yeo, Geok Lin Chua, Peter I. Benke, Markus R. Wenk, Lena Ho, Federico Torta, David L. Silver
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 119(40)
The lysosome is central to the degradation of proteins, carbohydrates, and lipids and their salvage back to the cytosol for reutilization. Lysosomal transporters for amino acids, sugars, and cholesterol have been identified, and the metabolic fates o
Autor:
Geok-Lin Chua, Bryan C. Tan, Randy Y. J. Loke, Menglan He, Cheen-Fei Chin, Bernice H. Wong, Alvin C. Y. Kuk, Mei Ding, Markus R. Wenk, Lan Guan, Federico Torta, David L. Silver
Publikováno v:
Proceedings of the National Academy of Sciences. 120
Major Facilitator Superfamily Domain containing 2a (Mfsd2a) is a sodium-dependent lysophosphatidylcholine (LPC) transporter expressed at the blood–brain barrier that constitutes the main pathway by which the brain obtains omega-3 fatty acids, such
GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation
Autor:
Ellene H. Mashalidis, Alvin C. Y. Kuk, Jiho Yoo, Kazuki Yamamoto, Satoshi Ichikawa, Benjamin Kaeser, Seok-Yong Lee
Publikováno v:
Nature structural & molecular biology
Summary N-linked glycosylation is a predominant post-translational modification of protein in eukaryotes, and its dysregulation is the etiology of several human disorders. The enzyme UDP-N-acetylglucosamine:dolichyl-phosphate N-acetylglucosaminephosp
Publikováno v:
Nature Structural & Molecular Biology. 24:171-176
Peptidoglycan (PG) protects bacteria from osmotic lysis, and its biogenesis is a key antibiotic target. A central step in PG biosynthesis is to flip the lipid-linked PG precursor lipid II across the cytoplasmic membrane for subsequent incorporation i
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-12 (2019)
Nature Communications
Nature Communications
The biosynthesis of many polysaccharides, including bacterial peptidoglycan and eukaryotic N-linked glycans, requires transport of lipid-linked oligosaccharide (LLO) precursors across the membrane by specialized flippases. MurJ is the flippase for th