Zobrazeno 1 - 9
of 9
pro vyhledávání: '"C W Filer"'
Publikováno v:
Xenobiotica. 25:477-490
1. Drug-related material was well absorbed following oral administration of 14C-famciclovir to the male rat at doses up to 4000 mg/kg and to the male dog at doses up to 250 mg/kg, as judged by the early onset of the peak blood or plasma concentration
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9b5e2e1e45640f26450d48fbe09c33d7
https://doi.org/10.3109/00498259509061867
https://doi.org/10.3109/00498259509061867
Autor:
F. J. Hollis, W. T. Prince, S. E. Fowles, G. D. Allen, T. A. Brown, E. E. Mort, J. V. Ramji, C. W. Filer
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 24(4)
1. Following oral administration of 14C-famciclovir (500 mg) to three healthy male subjects, drug-related material was rapidly absorbed as judged by peak plasma concentrations of radioactive material being achieved by 0.75 h (6.7 +/- 0.9 microgram eq
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ab8941a2d90071f955ef3916aa291119
https://pubmed.ncbi.nlm.nih.gov/8059539
https://pubmed.ncbi.nlm.nih.gov/8059539
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 22(7)
1. Disposition of the 3R,4S(+) and 3S,4R(-) enantiomers of the racemic antihypertensive drug cromakalim has been studied in rats and cynomolgus monkeys using the 14C-drug labelled in either the 3R,4S(+) or the 3S,4R(-) enantiomer. 2. After oral admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7676ad148ff079cbf1ca6d405dc89c3c
https://pubmed.ncbi.nlm.nih.gov/1455901
https://pubmed.ncbi.nlm.nih.gov/1455901
Publikováno v:
Xenobiotica. 11:863-870
1. A technique is described for the continuous collection of bile, for long periods, from unrestrained conscious rats housed in standard glass metabolism cages. 2. Bile is collected in cooled vessels outside the cage through a cannula which is exteri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::adf498d83740c9c8e4b6bc8c1450170d
https://doi.org/10.3109/00498258109045324
https://doi.org/10.3109/00498258109045324
Publikováno v:
Xenobiotica. 10:761-769
1. The absorption of the phenol moiety of [phenol-14C]carfecillin following oral administration to rat, dog and man was extensive, since 95%, 73% and 99% of the administered radioactivity respectively was recovered in the urine. In contrast, less tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1f3d9726bd7895cdb5e6e950af9fde84
https://doi.org/10.3109/00498258009033804
https://doi.org/10.3109/00498258009033804
Publikováno v:
Xenobiotica. 16:853-863
Following oral administration of potassium 14C-clavulanate to four human subjects, at least 73% of the radioactive dose was absorbed. The mean absolute bioavailability was 64%. Absorption was rapid with peak plasma concentrations of radioactivity and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b972f66a8fd2a6e19dad330e561d0a2
https://doi.org/10.3109/00498258609038967
https://doi.org/10.3109/00498258609038967
Publikováno v:
Xenobiotica. 14:483-490
At least one third of an oral dose of sodium [G-14C]clavulanate was absorbed by rat and dog. Excretion of radioactivity was rapid in both species. In addition to urinary and faecal excretion of radioactivity, appreciable elimination of 14CO2 occurred
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2563e8c811469a7542f0a1d22c8a4810
https://doi.org/10.3109/00498258409151435
https://doi.org/10.3109/00498258409151435
Publikováno v:
Journal of the Science of Food and Agriculture. 20:65-69
Radiochemically labelled (3-14C)-decoquinate (ethyl 6-n-decyloxy-7-ethoxy-4-hydroxyquinoline-3-carboxylate) has been synthesised and used to measure residues remaining in liver, kidney, teg muscle, breast muscle, blood, heart, fat and skin after admi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed41a7d6113d1f751ddc7c62805369ef
https://doi.org/10.1002/jsfa.2740200201
https://doi.org/10.1002/jsfa.2740200201
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 10(10)
1. Studies have shown that hydrolysis of carfecillin to carbenicillin and phenol in vitro occurs in blood, liver and gut tissues of rat and dog. Extremely rapid hydrolysis was observed in the blood and liver of the rat. 2. Absorption studies in intes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3c2a238502499f7b2a1328070ce874aa
https://pubmed.ncbi.nlm.nih.gov/7456492
https://pubmed.ncbi.nlm.nih.gov/7456492