Zobrazeno 1 - 10
of 4 744
pro vyhledávání: '"C W Chen"'
Publikováno v:
Climate of the Past, Vol 20, Pp 1513-1520 (2024)
The Okmok volcanic eruption in Alaska has recently been discovered and is precisely dated to have occurred in 43 BCE. Some Chinese climate records of 43–33 BCE have been found in historical documents that provide descriptions of observed environmen
Externí odkaz:
https://doaj.org/article/eac76e9703e4464ba038b02f676bed98
Publikováno v:
Frontiers in Physiology, Vol 14 (2024)
Stem/progenitor cells have been widely evaluated as a promising therapeutic option for heart failure (HF). Numerous clinical trials with stem/progenitor cell-based therapy (SCT) for HF have demonstrated encouraging results, but not without limitation
Externí odkaz:
https://doaj.org/article/ecb888ec863a4872a8efd3f69ca38c82
Autor:
William C. W. Chen, Leonid Gaidukov, Yong Lai, Ming-Ru Wu, Jicong Cao, Michael J. Gutbrod, Gigi C. G. Choi, Rachel P. Utomo, Ying-Chou Chen, Liliana Wroblewska, Manolis Kellis, Lin Zhang, Ron Weiss, Timothy K. Lu
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Precise and scalable regulation of gene expression in mammalian cells is challenging. Here, the authors created a highly tunable CRISPR-based synthetic transcription system for programmable control of mammalian gene expression and cellular activity.
Externí odkaz:
https://doaj.org/article/310dc9b5a9a34df28dfb75c848485687
Autor:
David A Smith, Elena-Raluca Nicoli, Oscar C W Chen, Alexandria Colaco, Stephan Siebel, Stephanie Newman, Dawn Shepherd, Nicole Y Farhat, Andrew E Armitage, Claire Smith, George Seligmann, Mylvaganam Jeyakumar, Alaa Abdul-Sada, Forbes D Porter, Hal Drakesmith, Frances M Platt, Nick Platt
Publikováno v:
Wellcome Open Research, Vol 7 (2023)
Background: Niemann-Pick disease type C1 (NPC1) is a neurodegenerative lysosomal storage disorder characterized by the accumulation of multiple lipids in the late endosome/lysosomal system and reduced acidic store calcium. The lysosomal system regula
Externí odkaz:
https://doaj.org/article/88e020958a694dd6970e032b17add1f9
Autor:
Jicong Cao, Eva Maria Novoa, Zhizhuo Zhang, William C. W. Chen, Dianbo Liu, Gigi C. G. Choi, Alan S. L. Wong, Claudia Wehrspaun, Manolis Kellis, Timothy K. Lu
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-10 (2021)
The engineering of 5′ UTRs that modulate protein expression remains a great challenge. Here we leverage synthetic biology and computational design to develop a high-throughput strategy to design, screen, and optimize 5′ UTRs that enhance protein
Externí odkaz:
https://doaj.org/article/7874f9ea0bf346329b2ba9f6b304ff50
Autor:
Oscar C. W. Chen, Alexandria Colaco, Lianne C. Davis, Fedir N. Kiskin, Nicole Y. Farhat, Anneliese O. Speak, David A. Smith, Lauren Morris, Emily Eden, Patricia Tynan, Grant C. Churchill, Antony Galione, Forbes D. Porter, Frances M. Platt
Publikováno v:
JIMD Reports, Vol 56, Iss 1, Pp 46-57 (2020)
Abstract Niemann‐Pick disease type C (NPC) is a neurodegenerative lysosomal storage disorder caused by mutations in either NPC1 (95% of cases) or NPC2. Reduced late endosome/lysosome calcium (Ca2+) levels and the accumulation of unesterified choles
Externí odkaz:
https://doaj.org/article/0e1a6412d2a14de1a7841b940a26ea33
Autor:
H. Uckelmann, S. Armstrong, E. Haarer, E. Wong, C. Hatton, F. Perner, C. Marinaccio, C.-W. Chen
Publikováno v:
HemaSphere, Vol 6, Pp 16-17 (2022)
Externí odkaz:
https://doaj.org/article/60d733c131a54fbab7f508caab676169
Autor:
E. Kugler, S. Madiwale, D. Yong, Y. Birger, J. A. I. Thoms, D. B. Sykes, M. Yassin, N. Aqaqe, A. Rein, H. Fishman, I. Geron, C.-W. Chen, B. Raught, Q. Liu, M. Milyavsky, J. Pimanda, G. G. Privé, S. Izraeli
Publikováno v:
HemaSphere, Vol 6, Pp 317-318 (2022)
Externí odkaz:
https://doaj.org/article/8ea4aeda60a9495c81f41edf9675ff39
Autor:
Teak V. Lee, Chang Woock Lee, Vincent C. W. Chen, Steve Bui, James D. Fluckey, Steven E. Riechman
Publikováno v:
Lipids in Health and Disease, Vol 18, Iss 1, Pp 1-12 (2019)
Abstract Background The loss of muscle mass and concomitantly strength, poses a serious risk to the elderly and to astronauts. Dietary cholesterol (CL), in conjunction with resistance training (RT), has been strongly associated with improvements in l
Externí odkaz:
https://doaj.org/article/fb5c886df70247d89ef9c258a4908522
Publikováno v:
Natural Hazards and Earth System Sciences, Vol 18, Pp 2877-2891 (2018)
One purpose of landslide research is to establish early warning thresholds for rainfall-induced landslides. Insufficient observations of past events have inhibited the analysis of critical rainfall conditions triggering landslides. This difficulty
Externí odkaz:
https://doaj.org/article/eb9a795884f94dffb92bdd8c6492d5b1