Zobrazeno 1 - 5
of 5
pro vyhledávání: '"C W Carreras"'
Publikováno v:
Journal of molecular graphicsmodelling. 18(4-5)
A virtual library of macrocyclic polyketide molecules was generated and screened to identify novel, conformationally constrained potential motilin receptor agonists ("motilides"). A motilide pharmacophore model was generated from the potent 6,9-enol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::8fe10a8a1bc227bd3cd1583e9a486810
https://pubmed.ncbi.nlm.nih.gov/11143565
https://pubmed.ncbi.nlm.nih.gov/11143565
Autor:
C W, Carreras, G W, Ashley
Publikováno v:
EXS. 89
Modular polyketide synthases (PKS) are large multifunctional proteins which direct the condensation of activated short chain carboxylic acids into products of defined length and functionality using a dedicated set of active sites, or module, for each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ebe172d1ca9fe29a4458129e0641b36d
https://pubmed.ncbi.nlm.nih.gov/10997284
https://pubmed.ncbi.nlm.nih.gov/10997284
Autor:
G W Ashley, C W Carreras
Publikováno v:
Experientia Supplementum ISBN: 9783034895477
Modular polyketide synthases (PKS) are large multifunctional proteins which direct the condensation of activated short chain carboxylic acids into products of defined length and functionality using a dedicated set of active sites, or module, for each
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::16d39c3bbbc2c7365fa05ceb4b87ae17
https://doi.org/10.1007/978-3-0348-8393-1_6
https://doi.org/10.1007/978-3-0348-8393-1_6
Autor:
C W, Carreras, C, Khosla
Publikováno v:
Biochemistry. 37(8)
A minimal set of proteins which catalyze the synthesis of aromatic polketides from malonyl CoA has been purified and partially characterized. Plasmid-encoded actinorhodin (act) ketosynthase/chain-length factor (KS/CLF) complex was purified from Strep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::90d8a798a0f047c477423f407116a423
https://pubmed.ncbi.nlm.nih.gov/9518007
https://pubmed.ncbi.nlm.nih.gov/9518007
Publikováno v:
Biochemistry. 36(39)
The functional reconstitution of two purified proteins of an aromatic polyketide synthase pathway, the acyl carrier protein (ACP) and holo-ACP synthase (ACPS), is described. Holo-ACPs were enzymatically synthesized from coenzyme A and apo-ACPs using
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::559c8edf89c1f471a0a4996052d60702
https://pubmed.ncbi.nlm.nih.gov/9305965
https://pubmed.ncbi.nlm.nih.gov/9305965