Zobrazeno 1 - 3
of 3
pro vyhledávání: '"C W Andrews Iii"'
Autor:
G S Lowell, John Milton, David I. Stuart, Joseph H. Chan, George Andrew Freeman, S S Gonzales, Steven A. Short, Jingshan Ren, Andrew L. Hopkins, K L Creech, Richard J. Hazen, R G Ferris, G W Koszalka, L T Schaller, G B Roberts, Cowan, C W Andrews Iii, Kurt Weaver, L R Boone, David K. Stammers, D J Reynolds
HIV-1 nonnucleoside reverse transcriptase inhibitors (NNRTIs) are part of the combination therapy currently used to treat HIV infection. The features of a new NNRTI drug for HIV treatment must include selective potent activity against both wild-type
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dba0381a0617d10120e121697f22e025
https://doi.org/10.1021/jm040072r
https://doi.org/10.1021/jm040072r
Autor:
Kurt Weaver, Jingshan Ren, L R Boone, R G Ferris, A Freeman, Steven A. Short, Anna Stamp, Richard J. Hazen, K.R Romines, C W Andrews Iii, P.P. Chamberlain, David K. Stammers, Joseph H. Chan
Publikováno v:
Journal of Medicinal Chemistry. 51:5000-5008
Owing to the emergence of resistant virus, next generation non-nucleoside HIV reverse transcriptase inhibitors (NNRTIs) with improved drug resistance profiles have been developed to treat HIV infection. Crystal structures of HIV-1 RT complexed with b
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::832c8ffe10f26487effda5730a48ae45
https://doi.org/10.1021/jm8004493
https://doi.org/10.1021/jm8004493
Autor:
R J Ott, Kurt Weaver, David K. Stammers, G F Orr, Joseph H. Chan, Andrew L. Hopkins, Douglas B. Sherman, Steven A. Short, R G Ferris, S M Sparks, M St Clair, David I. Stuart, C W Andrews Iii, Robert N. Hunter, B E Reitter, J S Hong, K L Creech, G B Roberts, Cowan, L R Boone, Jingshan Ren, Richard J. Hazen
Publikováno v:
Journal of medicinal chemistry. 44(12)
A series of 2-amino-5-arylthiobenzonitriles (1) was found to be active against HIV-1. Structural modifications led to the sulfoxides (2) and sulfones (3). The sulfoxides generally showed antiviral activity against HIV-1 similar to that of 1. The sulf
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69bc1966b43139f9d26bc16962ee2c49
https://pubmed.ncbi.nlm.nih.gov/11384233
https://pubmed.ncbi.nlm.nih.gov/11384233