Improvement in prediction of coronary heart disease risk over conventional risk factors using SNPs identified in genome-wide association studies.

Autor: Jennifer L Bolton, Marlene C W Stewart, James F Wilson, Niall Anderson, Jackie F Price

Publikováno v: PLoS ONE, Vol 8, Iss 2, p e57310 (2013)

We examined whether a panel of SNPs, systematically selected from genome-wide association studies (GWAS), could improve risk prediction of coronary heart disease (CHD), over-and-above conventional risk factors. These SNPs have already demonstrated re

Externí odkaz: https://doaj.org/article/437903eedc3d41e49049fc3b9162e679

GWAS for executive function and processing speed suggests involvement of the CADM2 gene

Autor: Igor Rudan, Daniel I. Chasman, Helena Schmidt, Stefan Herms, Sharon L.R. Kardia, Oliver Stegle, Alison Pattie, Jenna Price, Gerardo Heiss, Karen A. Mather, L. J. Launer, Johan G. Eriksson, Christopher Oldmeadow, Ian Ford, Saira Saeed Mirza, Alan F. Wright, Ozren Polasek, Joshua M. Shulman, Maria K. Jonsdottir, André G. Uitterlinden, Rodney J. Scott, Kurt Lohman, Anita L. DeStefano, Peter W. Schofield, Perminder S. Sachdev, Stefania Bandinelli, Johan Wouter Jukema, John M. Starr, Rudolf S N Fehrmann, Y. C. Hsieh, William M. Meeks, Paul M. Ridker, R.G.J. Westendorp, Le Yu, J. C. van Swieten, Vilmundur Gudnason, Myriam Fornage, Melissa Garcia, Carla A. Ibrahim-Verbaas, James F. Wilson, Jean-Charles Lambert, Qiong Yang, Laura H. Coker, Stella Trompet, Lina Zgaga, Jennifer A. Smith, David J. Llewellyn, Nicole A. Kochan, Ben A. Oostra, Katja Petrovic, Peter Hoffmann, Qi Sun, James T. Becker, Najaf Amin, Vincent Chouraki, Brendan M. Buckley, D C Liewald, Jun Ding, Christiane Wolf, P. L. DeJager, Reinhold Schmidt, Chloe Fawns-Ritchie, Stéphanie Debette, Jing Wang, J. C. Bis, Nicola J. Armstrong, David J. Stott, Albert Hofman, Nazanin Karbalai, G. Eiriksdottir, Luke C. Pilling, D. S. Knopman, Maaike Schuur, Alexa S. Beiser, Annette L. Fitzpatrick, David A. Bennett, Aarno Palotie, Lude Franke, Sven Cichon, Mirna Kirin, Markus M. Nöthen, Thomas H. Mosley, Lynda M. Rose, Alan J. Gow, Caroline Hayward, Lori B. Chibnik, Ian J. Deary, Albert V. Smith, Jan Bressler, T.B. Harris, Stephen T. Turner, David J. Porteous, C M van Duijn, M. A. Ikram, Elizabeth G. Holliday, Mike A. Nalls, Luigi Ferrucci, Sudha Seshadri, Francine Grodstein, Marlene C. W. Stewart, Philip A. Wolf, Alexander Teumer, P.E. Slagboom, Jerome I. Rotter, Blair H. Smith, Juha Karjalainen, Susan M. Resnick, A.J.M. de Craen, Toshiko Tanaka, Alan D. Penman, Hans-Jörgen Grabe, Gary Davies, Oscar L. Lopez, Yongmei Liu, Kristine Yaffe, Veronique Vitart, Stela McLachlan, Katri Räikkönen, Rebecca F. Gottesman, Rhoda Au, Lynne J. Hocking, Carsten Oliver Schmidt, John Attia, Bruce M. Psaty, Wei Zhao, Jari Lahti

Publikováno v: Molecular Psychiatry, 21(2), 189-197. Nature Publishing Group
Molecular Psychiatry, 21(2), 189-197
Ibrahim-Verbaas, C A, Bressler, J, Debette, S, Schuur, M, Smith, A V, Bis, J C, Davies, G, Trompet, S, Smith, J A, Wolf, C, Chibnik, L B, Liu, Y, Vitart, V, Kirin, M, Petrovic, K, Polasek, O, Zgaga, L, Fawns-Ritchie, C, Hoffmann, P, Karjalainen, J, Lahti, J, Llewellyn, D J, Schmidt, C O, Mather, K A, Chouraki, V, Sun, Q, Resnick, S M, Rose, L M, Oldmeadow, C, Stewart, M, Smith, B H, Gudnason, V, Yang, Q, Mirza, S S, Jukema, J W, deJager, P L, Harris, T B, Liewald, D, Amin, N, Gow, A J, Pattie, A, Starr, J M, McLachlan, S, Porteous, D J, Price, J F, Rudan, I, Hayward, C, Wright, A F & Wilson, J F & Deary, I 2016, ' GWAS for executive function and processing speed suggests involvement of the CADM2 gene ', Molecular Psychiatry, vol. 21, pp. 189-197 . https://doi.org/10.1038/mp.2015.37
Ibrahim-Verbaas, CA; Bressler, J; Debette, S; Schuur, M; Smith, AV; Bis, JC; et al.(2016). GWAS for executive function and processing speed suggests involvement of the CADM2 gene. MOLECULAR PSYCHIATRY, 21(2), 189-197. doi: 10.1038/mp.2015.37. UCLA: Retrieved from: http://www.escholarship.org/uc/item/7d8152n1
Molecular psychiatry 21(2), 189-197 (2015). doi:10.1038/mp.2015.37
Neurology Working Group of the CHARGE Consortium 2016, ' GWAS for executive function and processing speed suggests involvement of the CADM2 gene ', Molecular Psychiatry, vol. 21, no. 2, pp. 189-197 . https://doi.org/10.1038/mp.2015.37
Molecular psychiatry 21, 189–197 (2016). doi:10.1038/mp.2015.37

To access publisher's full text version of this article, please click on the hyperlink in Additional Links field or click on the hyperlink at the top of the page marked Files. This article is open access. To identify common variants contributing to n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbf11a1a3e166a98f0a244478f602cbf
https://hdl.handle.net/11370/3faba094-c578-4ed8-8cab-cb46bcdc7740

Angioplasty and stenting for peripheral arterial disease of the lower limbs:An overview of Cochrane Reviews

Autor: Marlene C. W. Stewart, Lindsay Robertson, Kosmas I Paraskevas

Publikováno v: Robertson, L, Paraskevas, K I & Stewart, M 2017, ' Angioplasty and stenting for peripheral arterial disease of the lower limbs : An overview of Cochrane Reviews ', Cochrane Database of Systematic Reviews, vol. 2017, no. 2, CD012542 . https://doi.org/10.1002/14651858.CD012542
The Cochrane Library

This is a protocol for a Cochrane Review (Overview). The objectives are as follows: To summarise the evidence from relevant Cochrane Reviews regarding effectiveness of angioplasty and stenting for peripheral arterial disease of the lower limbs.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::591f8d60cc5bedd4404fd70163fef1b1
https://www.pure.ed.ac.uk/ws/files/338128335/Robertson_et_al_2017_Cochrane_Database_of_Systematic_Reviews.pdf

D‐Dimer tests for the diagnosis of deep venous thrombosis in symptomatic hospital outpatients with a clinical prediction rule

Autor: Fay Crawford, Francesca M Chappell, Marlene C. W. Stewart, Marcello Di Nisio, Karen Welch, Lindsay Robertson, Alina Andras

Publikováno v: The Cochrane Library
Chappell, F M, Andras, A, Welch, K, Di Nisio, M, Robertson, L, Stewart, M & Crawford, F 2016, ' D-Dimer tests for the diagnosis of deep venous thrombosis in symptomatic hospital outpatients with a clinical prediction rule ', Cochrane Database of Systematic Reviews, vol. 2016, no. 9, CD012356 . https://doi.org/10.1002/14651858.CD012356

This is the protocol for a review and there is no abstract. The objectives are as follows: To estimate the sensitivity and specificity of the various types of D-dimer test in the diagnosis of deep vein thrombosis (DVT) of the lower limb in symptomati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::763dcf2674cb875e35719517ee835e08
https://europepmc.org/articles/PMC6457583/

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

Autor: John Connolly, John C. Whittaker, Helen Ireland, Hynek Pikhart, Olaf H. Klungel, Claudia Langenberg, Juan P. Casas, Y. van der Graaf, Anne Peasey, Emelia J. Benjamin, Meena Kumari, Nicholas J. Timpson, Růžena Kubínová, P.J. Talmud, Nita G. Forouhi, Verschuren Wmm., KaWah Li, Engmann Jel., C Chung, Tina Shah, Damiano Baldassarre, Mika Kivimäki, Eric J. Brunner, John Hardy, Karoline Kuchenbaecker, Charles B. Eaton, Y. T. van der Schouw, Michael V. Holmes, S. J. Bielinski, Jaroslav A. Hubacek, P. A. Doevendans, Susan Redline, Berta Almoguera Castillo, Westendorp Rgj., Reecha Sofat, Yiran Guo, Leslie A. Lange, Debbie A Lawlor, James G. Wilson, John Gallacher, Richard S. Houlston, Martin Bobak, Maarten Leusink, Andrzej Pajak, George Davey Smith, James F. Meschia, Peter H. Whincup, Rebecca Hardy, Michael Marmot, Jeffrey W. Stephens, Brendan J. Keating, Diana Kuh, Delaney Jac., Mikhail I. Voevoda, N. C. Onland-Moret, Timothy M. Frayling, Hakon Hakonarson, S Bandenelli, Frank Dudbridge, G Jan de Borst, F G Fowkes, Migle Baceviciene, Gordon D.O. Lowe, Gerjan Navis, Alexander P. Reiner, Simon P. Mooijaart, Phil Howard, Boer Jma., Stephen E. Epstein, A. de Boer, Ian Ford, U de Faire, Abdonas Tamosiunas, Malcolm G. Dunlop, AB Singleton, Nicholas J. Wareham, Renate B. Schnabel, Johan Wouter Jukema, Naveed Sattar, Folkert W. Asselbergs, Fotios Drenos, Jutta Palmen, Christina L. Wassel, Sofia Malyutina, Daniel I. Swerdlow, Tetsu Tanaka, Ron T. Gansevoort, Julian Peto, Jenna Price, Bakker Sjl., Ian Tomlinson, Yun Li, Bengt Sennblad, Jackie A. Cooper, Jian'an Luan, Aroon D. Hingorani, JoAnn E. Manson, Roman Pfister, Mailand-van der Zee A-H., I. Mateo Leach, Anders Hamsten, Mike A. Nalls, Yoav Ben-Shlomo, Richard W Morris, Joe Devaney, Marlene C. W. Stewart, P A de Jong, Steve E. Humphries, Roman Topor-Madry, P. van der Harst, Jennifer G. Robinson, Andrew Wong, Luigi Ferrucci, Elena Tremoli, Ioanna Tzoulaki, Mary-Susan Burnett

Publikováno v: The Lancet
The Lancet, 379(9822), 1214-1224. ELSEVIER SCIENCE INC
Hingorani, A D, Casas, J P, Price, J, Stewart, M & Dunlop, M & Tomlinson, I 2012, ' The interleukin-6 receptor as a target for prevention of coronary heart disease : a mendelian randomisation analysis ', The Lancet, vol. 379, no. 9822, pp. 1214-24 . https://doi.org/10.1016/S0140-6736(12)60110-X
The Lancet, 379(9822), 1214-1224. Elsevier Limited
Swerdlow, D I, Holmes, M V, Kuchenbaecker, K B, Engmann, J E L, Shah, T, Sofat, R, Guo, Y, Chung, C, Peasey, A & Timpson, N J & Casas, J P 2013, ' The interleukin-6 receptor as a target for prevention of coronary heart disease : a mendelian randomisation analysis ', Lancet, vol. 379, no. 9822, pp. 1214-1224 . https://doi.org/10.1016/S0140-6736(12)60110-X
The Lancet; Vol 379

SummaryBackgroundA high circulating concentration of interleukin 6 is associated with increased risk of coronary heart disease. Blockade of the interleukin-6 receptor (IL6R) with a monoclonal antibody (tocilizumab) licensed for treatment of rheumatoi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60303f253dccdcfa3075f1ed04fc1362