Zobrazeno 1 - 10
of 95
pro vyhledávání: '"C W, HUGHES"'
Publikováno v:
Frontiers in Bioengineering and Biotechnology, Vol 12 (2024)
The tumor microenvironment (TME) comprises a diverse array of cells, both cancerous and non-cancerous, including stromal cells and immune cells. Complex interactions among these cells play a central role in driving cancer progression, impacting criti
Externí odkaz:
https://doaj.org/article/b8df03292d2b4b84bbc9f5afd01a7671
Autor:
Stephanie J. Hachey, Christopher J. Hatch, Daniela Gaebler, Aneela Mocherla, Kevin Nee, Kai Kessenbrock, Christopher C. W. Hughes
Publikováno v:
Breast Cancer Research, Vol 26, Iss 1, Pp 1-20 (2024)
Abstract Triple-negative breast cancer (TNBC) is highly aggressive with limited available treatments. Stromal cells in the tumor microenvironment (TME) are crucial in TNBC progression; however, understanding the molecular basis of stromal cell activa
Externí odkaz:
https://doaj.org/article/533691dae4ce4633bab7504995ebb266
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 12 (2024)
The tumor microenvironment (TME) is a diverse milieu of cells including cancerous and non-cancerous cells such as fibroblasts, pericytes, endothelial cells and immune cells. The intricate cellular interactions within the TME hold a central role in sh
Externí odkaz:
https://doaj.org/article/dc0617337d014458a50b1e2f7c24b28a
Autor:
Christopher J. Hatch, Sebastian D. Piombo, Jennifer S. Fang, Johannes S. Gach, Makena L. Ewald, William K. Van Trigt, Brian G. Coon, Jay M. Tong, Donald N. Forthal, Christopher C. W. Hughes
Publikováno v:
Frontiers in Cardiovascular Medicine, Vol 11 (2024)
BackgroundSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2), responsible for COVID-19, has caused nearly 7 million deaths worldwide. Severe cases are marked by an aggressive inflammatory response known as hypercytokinemia, contributing to
Externí odkaz:
https://doaj.org/article/5e25787c77e74466b0cead1fdfb7b9f3
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-16 (2022)
Abstract Endothelial cells line all major blood vessels and serve as integral regulators of many functions including vessel diameter, cellular trafficking, and transport of soluble mediators. Despite similar functions, the phenotype of endothelial ce
Externí odkaz:
https://doaj.org/article/b6eda36a51c04631b605b0e9ebd1562b
Publikováno v:
Frontiers in Human Neuroscience, Vol 16 (2022)
Port-wine birthmarks (PWBs) are caused by somatic, mosaic mutations in the G protein guanine nucleotide binding protein alpha subunit q (GNAQ) and are characterized by the formation of dilated, dysfunctional blood vessels in the dermis, eyes, and/or
Externí odkaz:
https://doaj.org/article/c6e8b80429be423e9b6302e8a0afbfe3
Autor:
Tao Yue, Da Zhao, Duc T. T. Phan, Xiaolin Wang, Joshua Jonghyun Park, Zayn Biviji, Christopher C. W. Hughes, Abraham P. Lee
Publikováno v:
Microsystems & Nanoengineering, Vol 7, Iss 1, Pp 1-13 (2021)
Abstract The vascular network of the circulatory system plays a vital role in maintaining homeostasis in the human body. In this paper, a novel modular microfluidic system with a vertical two-layered configuration is developed to generate large-scale
Externí odkaz:
https://doaj.org/article/7e67611ba7b84c1aa78556f97992189c
Autor:
Nan W. Hultgren, Jennifer S. Fang, Mary E. Ziegler, Ricardo N. Ramirez, Duc T. T. Phan, Michaela M. S. Hatch, Katrina M. Welch-Reardon, Antonio E. Paniagua, Lin S. Kim, Nathan N. Shon, David S. Williams, Ali Mortazavi, Christopher C. W. Hughes
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Slug supports heart development and tumor metastasis, but its role in blood vessel formation is less clear. Here the authors show that endothelial cell-expressed Slug regulates both physiologic and pathological angiogenesis, at least in part through
Externí odkaz:
https://doaj.org/article/8e37d57515834f55b45498858d31ca32
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
During development and in several diseases, endothelial cells (EC) can undergo complete endothelial-to-mesenchymal transition (EndoMT or EndMT) to generate endothelial-derived mesenchymal cells. Emerging evidence suggests that ECs can also undergo a
Externí odkaz:
https://doaj.org/article/61f18773963a4109a738c59520d935a1
Autor:
Raksha Sreeramachandra Murthy, Rachel Elsanadi, Yan Li, John Soliman, Li-Dek Chou, Dennis Sprecher, Christopher C. W. Hughes, Kristen M. Kelly, Zhongping Chen
Publikováno v:
Optical Coherence Tomography and Coherence Domain Optical Methods in Biomedicine XXVII.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b552fddcb20c376a307cd94b273a4321
https://doi.org/10.1117/12.2650909
https://doi.org/10.1117/12.2650909