Zobrazeno 1 - 10
of 196
pro vyhledávání: '"C Thurmond"'
Autor:
Diana Esparza, Carinna Lima, Sarah Abuelreich, Ima Ghaeli, Jinhee Hwang, Eunjin Oh, Ayelet Lenz, Angel Gu, Nan Jiang, Fouad Kandeel, Debbie C. Thurmond, Tijana Jovanovic-Talisman
Publikováno v:
Frontiers in Endocrinology, Vol 15 (2024)
IntroductionDouble C2-like domain beta (DOC2B) is a vesicle priming protein critical for glucose-stimulated insulin secretion in β-cells. Individuals with type 1 diabetes (T1D) have lower levels of DOC2B in their residual functional β-cell mass and
Externí odkaz:
https://doaj.org/article/49be9d7536124d169961b687cb510217
Autor:
Weiwei Xu, M.M. Fahd Qadir, Daniela Nasteska, Paula Mota de Sa, Caroline M. Gorvin, Manuel Blandino-Rosano, Charles R. Evans, Thuong Ho, Evgeniy Potapenko, Rajakrishnan Veluthakal, Fiona B. Ashford, Stavroula Bitsi, Jia Fan, Manika Bhondeley, Kejing Song, Venkata N. Sure, Siva S.V.P. Sakamuri, Lina Schiffer, Wandy Beatty, Rachael Wyatt, Daniel E. Frigo, Xiaowen Liu, Prasad V. Katakam, Wiebke Arlt, Jochen Buck, Lonny R. Levin, Tony Hu, Jay Kolls, Charles F. Burant, Alejandra Tomas, Matthew J. Merrins, Debbie C. Thurmond, Ernesto Bernal-Mizrachi, David J. Hodson, Franck Mauvais-Jarvis
Publikováno v:
Cell Reports, Vol 42, Iss 5, Pp 112529- (2023)
Summary: Male mice lacking the androgen receptor (AR) in pancreatic β cells exhibit blunted glucose-stimulated insulin secretion (GSIS), leading to hyperglycemia. Testosterone activates an extranuclear AR in β cells to amplify glucagon-like peptide
Externí odkaz:
https://doaj.org/article/557572b83b5a4a7ca84c9f23c0810f39
Autor:
Karla E. Merz, Jinhee Hwang, Chunxue Zhou, Rajakrishnan Veluthakal, Erika M. McCown, Angelica Hamilton, Eunjin Oh, Wenting Dai, Patrick T. Fueger, Lei Jiang, Janice. M. Huss, Debbie C. Thurmond
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
STX4 is a regulator of the glucose transporter GLUT4 vesicle fusion at the plasma membrane in skeletal muscle. Here, the authors show that skeletal muscle-specific STX4 enrichment reverses established insulin resistance and improves mitochondrial fun
Externí odkaz:
https://doaj.org/article/86d199eac4974e6cb433219b443e6627
Autor:
Rekha Balakrishnan, Pablo A. Garcia, Rajakrishnan Veluthakal, Janice M. Huss, Joseph M. Hoolachan, Debbie C. Thurmond
Publikováno v:
Antioxidants, Vol 12, Iss 9, p 1658 (2023)
The p21-activated kinase 1 (PAK1) is required for insulin-stimulated glucose uptake in skeletal muscle cells. However, whether PAK1 regulates skeletal muscle mitochondrial function, which is a central determinant of insulin sensitivity, is unknown. H
Externí odkaz:
https://doaj.org/article/fa5f47e8f89f4b80a08ae9cc988484c8
Autor:
Jinhee Hwang, Debbie C. Thurmond
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Insulin-stimulated glucose uptake in skeletal muscle is of fundamental importance to prevent postprandial hyperglycemia, and long-term deficits in insulin-stimulated glucose uptake underlie insulin resistance and type 2 diabetes. Skeletal muscle is r
Externí odkaz:
https://doaj.org/article/d0a5bb5d8eeb463db11cfc7b7dae1cb1
Autor:
Karla E. Merz, Ragadeepthi Tunduguru, Miwon Ahn, Vishal A. Salunkhe, Rajakrishnan Veluthakal, Jinhee Hwang, Supriyo Bhattacharya, Erika M. McCown, Pablo A. Garcia, Chunxue Zhou, Eunjin Oh, Stephanie M. Yoder, Jeffrey S. Elmendorf, Debbie C. Thurmond
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Skeletal muscle accounts for ~80% of insulin-stimulated glucose uptake. The Group I p21–activated kinase 1 (PAK1) is required for the non-canonical insulin-stimulated GLUT4 vesicle translocation in skeletal muscle cells. We found that the abundance
Externí odkaz:
https://doaj.org/article/e88ac9a07c75452aa77f8a95a9d4da38
Autor:
Janine C. Quijano, Lena Wedeken, Jose A. Ortiz, Heather N. Zook, Jeanne M. LeBon, Angela Luo, Jeffrey Rawson, Jacob R. Tremblay, Jacob M. Mares, Kassandra Lopez, Min-Hsuan Chen, Kevin Jou, Carlos Mendez-Dorantes, Ismail H. Al-Abdullah, Debbie C. Thurmond, Fouad Kandeel, Arthur D. Riggs, Hsun Teresa Ku
Publikováno v:
Stem Cell Reports. 18:618-635
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5fd152cf65cef26b23fdadd02ba2bbf6
https://doi.org/10.1016/j.stemcr.2023.02.001
https://doi.org/10.1016/j.stemcr.2023.02.001
Publikováno v:
Frontiers in Endocrinology, Vol 11 (2020)
Externí odkaz:
https://doaj.org/article/7846c26511374563870dccd425a235b6
Publikováno v:
Cells, Vol 10, Iss 6, p 1503 (2021)
Several small guanosine triphosphatases (GTPases) from the Ras protein superfamily regulate glucose-stimulated insulin secretion in the pancreatic islet β-cell. The Rho family GTPases Cdc42 and Rac1 are primarily involved in relaying key signals in
Externí odkaz:
https://doaj.org/article/78440518a30b444990c1b02cb40fa3d4
Autor:
Diti Chatterjee Bhowmick, Arianne Aslamy, Supriyo Bhattacharya, Eunjin Oh, Miwon Ahn, Debbie C. Thurmond
Publikováno v:
Diabetes
Double C2 Domain Β (DOC2b) protein is required for glucose-stimulated insulin secretion (GSIS) in β-cells, the underlying mechanism of which remains unresolved. Our biochemical analysis using primary human islets, human and rodent clonal β-cells r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74facfba2101ed3fb4483ebe259590f5
https://doi.org/10.2337/db21-0681
https://doi.org/10.2337/db21-0681