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Effects of A-134974, a novel adenosine kinase inhibitor, on carrageenan-induced inflammatory hyperalgesia and locomotor activity in rats: evaluation of the sites of action

Autor: S, McGaraughty, K L, Chu, C T, Wismer, J, Mikusa, C Z, Zhu, M, Cowart, E A, Kowaluk, M F, Jarvis

Publikováno v: The Journal of pharmacology and experimental therapeutics. 296(2)

The present study investigated 1) antihyperalgesic actions of a novel and selective adenosine kinase (AK) inhibitor, A-134974 (IC(50) = 60 pM), in the carrageenan model of thermal hyperalgesia; 2) effects of A-134974 on locomotor activity; and 3) rel

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::fbeeb138a3f407ef6da31b6e0adb97b6
https://pubmed.ncbi.nlm.nih.gov/11160637

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ABT-702 (4-amino-5-(3-bromophenyl)-7-(6-morpholino-pyridin- 3-yl)pyrido[2,3-d]pyrimidine), a novel orally effective adenosine kinase inhibitor with analgesic and anti-inflammatory properties. II. In vivo characterization in the rat

Autor: E A, Kowaluk, J, Mikusa, C T, Wismer, C Z, Zhu, E, Schweitzer, J J, Lynch, C H, Lee, M, Jiang, S S, Bhagwat, A, Gomtsyan, J, McKie, B F, Cox, J, Polakowski, G, Reinhart, M, Williams, M F, Jarvis

Publikováno v: The Journal of pharmacology and experimental therapeutics. 295(3)

Adenosine kinase (AK; EC 2.7.1.20) is a key intracellular enzyme regulating intra-and extracellular concentrations of adenosine (ADO), an endogenous neuromodulator, antinociceptive, and anti-inflammatory autocoid. AK inhibition provides a means of po

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::dca8307c3455e88467a2b80df2b4e371
https://pubmed.ncbi.nlm.nih.gov/11082454

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