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Tumor-suppressive effects of neutral endopeptidase in androgen-independent prostate cancer cells

Autor: J, Dai, R, Shen, M, Sumitomo, J S, Goldberg, Y, Geng, D, Navarro, S, Xu, J A, Koutcher, M, Garzotto, C T, Powell, D M, Nanus

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(5)

Expression of neutral endopeptidase (NEP) 24.11 is diminished in metastatic, androgen-independent prostate cancers (PCs; C. N. Papandreou et al., NAT: MED:, 4: 50--57, 1998). To determine the effects on androgen-independent PC cells of overexpressing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::78f771c4ca3ee03c854305aa5018faaf
https://pubmed.ncbi.nlm.nih.gov/11350908

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Bryostatin 1 induces prolonged activation of extracellular regulated protein kinases in and apoptosis of LNCaP human prostate cancer cells overexpressing protein kinase calpha

Autor: J E, Gschwend, W R, Fair, C T, Powell

Publikováno v: Molecular pharmacology. 57(6)

Previously, we reported that 12-O-tetradecanoylphorbol-13-acetate (TPA)-induced apoptosis of LNCaP human prostate cancer cells was accompanied by prolonged translocation of protein kinase C (PKC)alpha to non-nuclear membranes and that TPA-resistant L

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ecd3c645bd191cef6f8e075dacd2730a
https://pubmed.ncbi.nlm.nih.gov/10825394

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E-cadherin mediates aggregation-dependent survival of prostate and mammary epithelial cells through the retinoblastoma cell cycle control pathway

Autor: Xin Zhao, M. Putzi, Mark L. Day, Christopher J. Vallorosi, Cheng-mao Lin, Kathleen C. Day, C. T. Powell

Publikováno v: The Journal of biological chemistry. 274(14)

E-cadherin and the retinoblastoma tumor suppressor (Rb) are traditionally associated with diverse regulatory aspects of cell growth and differentiation. However, we have discovered new evidence, which suggests that these proteins are functionally lin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fd338ecd656fe64e590e075ec693ce47
https://pubmed.ncbi.nlm.nih.gov/10092652

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Evaluation of the tetracycline-repressible transactivator system for inducible gene expression in human prostate cancer cell lines

Autor: J E, Gschwend, W R, Fair, C T, Powell

Publikováno v: The Prostate. 33(3)

Studies of genes that may inhibit growth or induce death of cells are facilitated greatly by tightly controlled expression of those genes. A promising system for control of transgene expression over a wide range is the tetracycline-repressible transa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::0e88dd2e0a9ad9aae4a954bc96ef9e99
https://pubmed.ncbi.nlm.nih.gov/9365544

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Overexpression of protein kinase C-zeta (PKC-zeta) inhibits invasive and metastatic abilities of Dunning R-3327 MAT-LyLu rat prostate cancer cells

Autor: C T, Powell, J E, Gschwend, W R, Fair, N J, Brittis, D, Stec, R, Huryk

Publikováno v: Cancer research. 56(18)

Previously, we reported that protein kinase C (PKC)-zeta mRNA levels are reduced markedly in metastatic Dunning R-3327 rat prostate tumors relative to the nonmetastatic Dunning H tumor and normal rat prostate (C.T. Powell et al., Cell GrowthDiffer.,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::8afbb6915d553737895c63864eb60bec
https://pubmed.ncbi.nlm.nih.gov/8797581

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Persistent membrane translocation of protein kinase C alpha during 12-0-tetradecanoylphorbol-13-acetate-induced apoptosis of LNCaP human prostate cancer cells

Autor: C T, Powell, N J, Brittis, D, Stec, H, Hug, W D, Heston, W R, Fair

Publikováno v: Cell growthdifferentiation : the molecular biology journal of the American Association for Cancer Research. 7(4)

Others have reported that the phorbol ester 12-0-tetradecanoylphorbol-13-acetate (TPA), an activator and down-regulator of most protein kinase C (PKC) isozymes, can induce apoptotic cell death of androgen-sensitive LNCaP but not androgen-insensitive

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::583b76d86006ca59f33c6f12864ae4c5
https://pubmed.ncbi.nlm.nih.gov/9052983

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Alternatively spliced variants of prostate-specific membrane antigen RNA: ratio of expression as a potential measurement of progression

Autor: S L, Su, I P, Huang, W R, Fair, C T, Powell, W D, Heston

Publikováno v: Cancer research. 55(7)

We examined expression of prostate-specific membrane antigen (PSM) mRNA in normal prostate using reverse transcription-PCR and sequencing. An alternatively spliced variant, PSM', along with the previously described PSM form, was found in normal prost

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::29808963c138d0ddb0747c012eb8656a
https://pubmed.ncbi.nlm.nih.gov/7882349

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Reversal by transferrin of growth-inhibitory effect of suramin on hormone-refractory human prostate cancer cells

Autor: Warren D. W. Heston, William R. Fair, C. T. Powell, S M Donat, Ron S. Israeli

Publikováno v: Journal of the National Cancer Institute. 87(1)

Background : The second leading cause of cancer-related deaths in American men is metastatic hormone-refractory adenocarcinoma of the prostate, for which there is currently no effective treatment. Transferrin is abundant in bone stroma and has been f

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8de13f67662ed8665a07c7e756b92903
https://pubmed.ncbi.nlm.nih.gov/7666462

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