Zobrazeno 1 - 10
of 31
pro vyhledávání: '"C T, Lutz"'
Publikováno v:
The Journal of Immunology. 158:2805-2812
T cells recognize MHC-bound peptide, suggesting that the TCR contacts surface MHC residues adjacent to bound peptide, but the extent of MHC contact is not known. T cells also may recognize peptide-induced conformational changes, and alloreactive T ce
Publikováno v:
The Journal of Immunology. 157:4503-4510
MHC class I molecules require the assembly of heavy chain with beta2-microglobulin (beta 2m) and peptide in order to present Ag on the cell surface. Endoplasmic reticulum resident proteins associate with class I molecules and aid assembly. Free class
Autor:
K D Smith, B E Mace, A Valenzuela, J L Vigna, J A McCutcheon, J A Barbosa, E Huczko, V H Engelhard, C T Lutz
Publikováno v:
The Journal of Immunology. 157:2470-2478
To determine the influence of peptide-binding groove residues and MHC-bound peptide on HLA-B7 conformation, we investigated the binding sites of nine locus- or allele-specific mAbs using a panel of 82 HLA-B7 variants. The functional mAb epitopes enci
Publikováno v:
The Journal of Immunology. 156:3755-3764
Class I MHC Ag presentation and cell surface expression largely depend on peptide transport into the ER/cis-Golgi by TAP, the transporter associated with Ag processing. Despite this dependency, class I MHC molecules are expressed at low levels on the
Publikováno v:
The Journal of Immunology. 154:2631-2641
NK cells directly or indirectly recognize MHC class I molecules, but the exact structures recognized remain poorly defined. We address the hypothesis that NK cells, like T cells, directly contact peptide/MHC class I complexes. This hypothesis predict
Publikováno v:
The Journal of Immunology. 153:4099-4110
Bw4 and BW6 epitopes are expressed by mutually exclusive sets of HLA-B alleles and some HLA-A and HLA-C alleles. To test whether antithetical structures are required to express Bw4 and Bw6 epitopes, we measured binding of Bw4-reactive and Bw6-reactiv
Autor:
W. A. Simmons, A. K. Schoner, C. T. Lutz, K. R. Walker, L. J. Weber, J. E. Wedekind, Don W. Byerly, J.C.B. Simonson, R. E. Johnson, W. W. Diehl, M. Ghazizadeh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3502d2cc1a2fe776c5d5d3cb7e7528f1
https://doi.org/10.1130/0-8137-5406-2.131
https://doi.org/10.1130/0-8137-5406-2.131
Publikováno v:
European journal of immunology. 30(10)
To explore the nature of amino acid substitutions that influence association with TAP, we compared a site-directed mutant of HLA-B*0702 (Y116D) to unmutated HLA-B7 in regard to TAP interaction. We found that the mutant had stronger association with T
Autor:
C T, Lutz, Z B, Kurago
Publikováno v:
Cancer research. 59(22)
Human leukocyte antigen (HLA) class I molecules on hematopoietic cancers and melanomas inhibit attack by natural killer lymphocytes, but previous studies have not consistently demonstrated that carcinoma cells are protected by HLA class I expression.
Autor:
C T, Lutz, P A, Foster, W W, Noll, K V, Voelkerding, R D, Press, R C, McGlennen, N E, Kirschbaum
Publikováno v:
Clinical chemistry. 44(6 Pt 1)