Zobrazeno 1 - 10
of 223
pro vyhledávání: '"C T, Lutz"'
Publikováno v:
The Journal of Immunology. 158:2805-2812
T cells recognize MHC-bound peptide, suggesting that the TCR contacts surface MHC residues adjacent to bound peptide, but the extent of MHC contact is not known. T cells also may recognize peptide-induced conformational changes, and alloreactive T ce
Publikováno v:
The Journal of Immunology. 157:4503-4510
MHC class I molecules require the assembly of heavy chain with beta2-microglobulin (beta 2m) and peptide in order to present Ag on the cell surface. Endoplasmic reticulum resident proteins associate with class I molecules and aid assembly. Free class
Autor:
K D Smith, B E Mace, A Valenzuela, J L Vigna, J A McCutcheon, J A Barbosa, E Huczko, V H Engelhard, C T Lutz
Publikováno v:
The Journal of Immunology. 157:2470-2478
To determine the influence of peptide-binding groove residues and MHC-bound peptide on HLA-B7 conformation, we investigated the binding sites of nine locus- or allele-specific mAbs using a panel of 82 HLA-B7 variants. The functional mAb epitopes enci
Publikováno v:
The Journal of Immunology. 156:3755-3764
Class I MHC Ag presentation and cell surface expression largely depend on peptide transport into the ER/cis-Golgi by TAP, the transporter associated with Ag processing. Despite this dependency, class I MHC molecules are expressed at low levels on the
Publikováno v:
The Journal of Immunology. 154:2631-2641
NK cells directly or indirectly recognize MHC class I molecules, but the exact structures recognized remain poorly defined. We address the hypothesis that NK cells, like T cells, directly contact peptide/MHC class I complexes. This hypothesis predict
Publikováno v:
The Journal of Immunology. 153:4099-4110
Bw4 and BW6 epitopes are expressed by mutually exclusive sets of HLA-B alleles and some HLA-A and HLA-C alleles. To test whether antithetical structures are required to express Bw4 and Bw6 epitopes, we measured binding of Bw4-reactive and Bw6-reactiv
Autor:
Zhang, Xiaogang1 (AUTHOR), Greve, Patrick F.2 (AUTHOR), Minh, Thi Tran Ngoc1,3 (AUTHOR), Wubbolts, Richard1 (AUTHOR), Demir, Ayşe Y.4 (AUTHOR), Zaal, Esther A.1,3 (AUTHOR), Berkers, Celia R.1,3 (AUTHOR), Boes, Marianne2 (AUTHOR), Stoorvogel, Willem1 (AUTHOR) w.stoorvogel@uu.nl
Publikováno v:
Journal of Extracellular Vesicles. Jul2024, Vol. 13 Issue 7, p1-22. 22p.
Autor:
Chen, Luxia1 (AUTHOR) luxia.chen@med.uni-heidelberg.de, Lei, Xuan1 (AUTHOR), Mahnke, Karsten1 (AUTHOR) karsten.mahnke@med.uni-heidelberg.de
Publikováno v:
International Journal of Molecular Sciences. Jun2024, Vol. 25 Issue 11, p5810. 22p.
Autor:
W. A. Simmons, A. K. Schoner, C. T. Lutz, K. R. Walker, L. J. Weber, J. E. Wedekind, Don W. Byerly, J.C.B. Simonson, R. E. Johnson, W. W. Diehl, M. Ghazizadeh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3502d2cc1a2fe776c5d5d3cb7e7528f1
https://doi.org/10.1130/0-8137-5406-2.131
https://doi.org/10.1130/0-8137-5406-2.131
Publikováno v:
European journal of immunology. 30(10)
To explore the nature of amino acid substitutions that influence association with TAP, we compared a site-directed mutant of HLA-B*0702 (Y116D) to unmutated HLA-B7 in regard to TAP interaction. We found that the mutant had stronger association with T