Zobrazeno 1 - 10 of 126 pro vyhledávání: '"C T, Esmon"'
1
Surface expression and functional characterization of α-granule factor V in human platelets: effects of ionophore A23187, thrombin, collagen, and convulxin
Autor: Kenneth J. Clemetson, Lorenzo Alberio, O. Safa, C. T. Esmon, G. L. Dale
Publikováno v: Blood. 95:1694-1702
Factor V (FV) present in platelet alpha-granules has a significant but incompletely understood role in hemostasis. This report demonstrates that a fraction of platelets express very high levels of surface-bound, alpha-granule FV on simultaneous activ
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aac4d4c6d7cab1bd0b91897838b3ebfd
https://doi.org/10.1182/blood.v95.5.1694.005k24_1694_1702
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2
Protein S and protein C Biochemistry, physiology, and clinical manifestation of deficiencies
Autor: C T, Esmon
Publikováno v: Trends in cardiovascular medicine. 2(6)
Protein C and protein S are two plasma proteins that participate in an anticoagulant pathway. Protein C circulates as an inactive precursor that is converted to an active serine protease by a complex between thrombin and the endothelial cell-surface
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::32c223f1cbfcac3e5e63c1ea39bc5584
https://pubmed.ncbi.nlm.nih.gov/21239244
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3
The role of thrombin's Tyr-Pro-Pro-Trp motif in the interaction with fibrinogen, thrombomodulin, protein C, antithrombin III, and the Kunitz inhibitors
Autor: R. T. A. Macgillivray, C. T. Esmon, B. F. Le Bonniec, E. R. Guinto, Stuart R. Stone
Publikováno v: Publons
Scopus-Elsevier
When amino acids Pro60B, Pro60C, and Trp60D are deleted from thrombin, the resulting mutant (des-PPW) exhibits (compared to the wild-type enzyme): a similar second order rate constant of inhibition (k(on)) for diisopropyl fluorophosphate, and a compa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0dc1f8bbed73d3918085f1b4f96cb78
https://doi.org/10.1016/s0021-9258(17)46734-2
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4
Design of constructs for the expression of biologically active recombinant human factors X and Xa. Kinetic analysis of the expressed proteins
Autor: D. L. Wolf, C. T. Esmon, T. E. Hancock, W. R. Church, Uma Sinha, T. L. Messier, Pei-Hua Lin
Publikováno v: Journal of Biological Chemistry. 266:13726-13730
Activation of vitamin K-dependent plasma proteases occurs by specific interaction with components of the blood coagulation cascade. In this report, we describe the direct expression and enzymatic characterization of the human coagulation zymogen fact
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::334f03466587339f6bf1ff5d5745fefd
https://doi.org/10.1016/s0021-9258(18)92759-6
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6
Role of coagulation inhibitors in inflammation
Autor: C T, Esmon
Publikováno v: Thrombosis and haemostasis. 86(1)
It is becoming increasingly clear that coagulation augments inflammation and that anticoagulants, particularly natural anticoagulants, can limit the coagulation induced increases in the inflammatory response. The latter control mechanisms appear to i
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::bab156fa39ca4bc44eebfa7cc59be307
https://pubmed.ncbi.nlm.nih.gov/11487041
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7
Identification of the protein C/activated protein C binding sites on the endothelial cell protein C receptor. Implications for a novel mode of ligand recognition by a major histocompatibility complex class 1-type receptor
Autor: P C, Liaw, T, Mather, N, Oganesyan, G L, Ferrell, C T, Esmon
Publikováno v: The Journal of biological chemistry. 276(11)
The endothelial cell protein C receptor (EPCR) is an endothelial cell-specific transmembrane protein that binds both protein C and activated protein C (APC). EPCR regulates the protein C anticoagulant pathway by binding protein C and augmenting prote
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a45963ef7586d255c0b8e45088e0d3ef
https://pubmed.ncbi.nlm.nih.gov/11099506
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9
Endotoxin and thrombin elevate rodent endothelial cell protein C receptor mRNA levels and increase receptor shedding in vivo
Autor: J M, Gu, Y, Katsuura, G L, Ferrell, P, Grammas, C T, Esmon
Publikováno v: Blood. 95(5)
The endothelial cell protein C receptor (EPCR) facilitates protein C activation by the thrombin-thrombomodulin complex. Protein C activation has been shown to be critical to the host defense against septic shock. In cell culture, tumor necrosis facto
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::a45e8e434636158ab7ed079f5b46cff1
https://pubmed.ncbi.nlm.nih.gov/10688825
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10
Antibodies to thrombomodulin are found in patients with lupus anticoagulant and unexplained thrombosis
Autor: C W, Carson, P C, Comp, A R, Rezaie, N L, Esmon, C T, Esmon
Publikováno v: The Journal of rheumatology. 27(2)
To test the hypothesis that thrombomodulin (TM) may be a target for lupus anticoagulant (LAC) antibodies.A recombinant soluble form of TM was produced and used as an antigen for an ELISA to detect antibodies to TM (TMAB). Sixty-one samples from 58 pa
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::6bab42b7be5bf17b9da7d55307a487bb
https://pubmed.ncbi.nlm.nih.gov/10685802
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