Zobrazeno 1 - 10
of 427
pro vyhledávání: '"C Skala"'
Autor:
Kehinde Adebayo Babatunde, Rupsa Datta, Nathan W. Hendrikse, Jose M. Ayuso, Anna Huttenlocher, Melissa C. Skala, David J. Beebe, Sheena C. Kerr
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110632- (2024)
Summary: The tumor microenvironment (TME) is characterized by a network of cancer cells, recruited immune cells, and extracellular matrix (ECM). However, the specific role of neutrophils during tumor development, and their interactions with other imm
Externí odkaz:
https://doaj.org/article/f7d54eb5b2a349b387ba54a749533678
Autor:
Gina M. Gallego-López, Emmanuel Contreras Guzman, Danielle E. Desa, Laura J. Knoll, Melissa C. Skala
Publikováno v:
mBio, Vol 15, Iss 8 (2024)
ABSTRACT Toxoplasma gondii, the causative agent of toxoplasmosis, is an obligate intracellular parasite that infects warm-blooded vertebrates across the world. In humans, seropositivity rates of T. gondii range from 10% to 90% across communities. Des
Externí odkaz:
https://doaj.org/article/ba66b0be49f948d6b92b311449b3a0f0
Autor:
Dan Cappabianca, Dan Pham, Matthew H. Forsberg, Madison Bugel, Anna Tommasi, Anthony Lauer, Jolanta Vidugiriene, Brookelyn Hrdlicka, Alexandria McHale, Quaovi H. Sodji, Melissa C. Skala, Christian M. Capitini, Krishanu Saha
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 32, Iss 2, Pp 101249- (2024)
Manufacturing chimeric antigen receptor (CAR) T cell therapies is complex, with limited understanding of how medium composition impacts T cell phenotypes. CRISPR-Cas9 ribonucleoproteins can precisely insert a CAR sequence while disrupting the endogen
Externí odkaz:
https://doaj.org/article/74f39a1628344c7f928bd6f3024b4800
Autor:
Jose M. Ayuso, Mehtab Farooqui, María Virumbrales-Muñoz, Katheryn Denecke, Shujah Rehman, Rebecca Schmitz, Jorge F. Guerrero, Cristina Sanchez-de-Diego, Sara Abizanda Campo, Elizabeth M. Maly, Matthew H. Forsberg, Sheena C. Kerr, Robert Striker, Nathan M. Sherer, Paul M. Harari, Christian M. Capitini, Melissa C. Skala, David J. Beebe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract Numerous studies are exploring the use of cell adoptive therapies to treat hematological malignancies as well as solid tumors. However, there are numerous factors that dampen the immune response, including viruses like human immunodeficiency
Externí odkaz:
https://doaj.org/article/d8131a18a7bf40c7bef3be77d0080137
Autor:
Cristina Sanchez-de-Diego, María Virumbrales-Muñoz, Brock Hermes, Terry D. Juang, Duane S. Juang, Jeremiah Riendeau, Emmanuel Contreras Guzman, Catherine A. Reed-McBain, Sara Abizanda-Campo, Janmesh Patel, Nicholas J. Hess, Melissa C. Skala, David J. Beebe, Jose M. Ayuso
Publikováno v:
Communications Biology, Vol 6, Iss 1, Pp 1-11 (2023)
Abstract Biological tissues are highly organized structures where spatial-temporal gradients (e.g., nutrients, hypoxia, cytokines) modulate multiple physiological and pathological processes including inflammation, tissue regeneration, embryogenesis,
Externí odkaz:
https://doaj.org/article/3a62387040b74a908ac77ab942071cd9
Autor:
Anna Hoefges, Paul M Sondel, Alexander L Rakhmilevich, Arika S Feils, Alina A Hampton, Noah W Tsarovsky, Amy K Erbe-Gurel, Alexa R Heaton, Nathaniel J Burkard, Garrett M Lublin, Melissa C Skala
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/4974d29cc9e9470d91ac46ce206f9c5d
Autor:
Alexa R. Heaton, Peter R. Rehani, Anna Hoefges, Angelica F. Lopez, Amy K. Erbe, Paul M. Sondel, Melissa C. Skala
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionMetabolic reprogramming of cancer and immune cells occurs during tumorigenesis and has a significant impact on cancer progression. Unfortunately, current techniques to measure tumor and immune cell metabolism require sample destruction an
Externí odkaz:
https://doaj.org/article/c2c82cf09a1d44eca7d13b82746ddc1c
Autor:
Rebecca A. DeStefanis, Jeremy D. Kratz, Autumn M. Olson, Aishwarya Sunil, Alyssa K. DeZeeuw, Amani A. Gillette, Gioia C. Sha, Katherine A. Johnson, Cheri A. Pasch, Linda Clipson, Melissa C. Skala, Dustin A. Deming
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Representative models are needed to screen new therapies for patients with cancer. Cancer organoids are a leap forward as a culture model that faithfully represents the disease. Mouse-derived cancer organoids (MDCOs) are becoming increasingl
Externí odkaz:
https://doaj.org/article/0850400bc08146908046414b05f6fcca
Autor:
Jose M. Ayuso, Mehtab Farooqui, María Virumbrales-Muñoz, Katheryn Denecke, Shujah Rehman, Rebecca Schmitz, Jorge F. Guerrero, Cristina Sanchez-de-Diego, Sara Abizanda Campo, Elizabeth M. Maly, Matthew H. Forsberg, Sheena C. Kerr, Robert Striker, Nathan M. Sherer, Paul M. Harari, Christian M. Capitini, Melissa C. Skala, David J. Beebe
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/6de22253fd77422a9d0bcadd8d281742
Autor:
Tongcheng Qian, Tiffany M. Heaster, Angela R. Houghtaling, Kexin Sun, Kayvan Samimi, Melissa C. Skala
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
Differentiation of hPSCs to cardiomyocytes suffers from high variability. Here the authors report a label-free live cell imaging platform based on autofluorescence imaging to enable the prediction of cardiomyocyte differentiation efficiency from hPSC
Externí odkaz:
https://doaj.org/article/c5d52f0785354812a3fc8a57e5918298