Zobrazeno 1 - 10
of 349
pro vyhledávání: '"C Seabra"'
Autor:
Matilde V. Neto, Giulia De Rossi, Bruce A. Berkowitz, Miguel C. Seabra, Philip J. Luthert, Clare E. Futter, Thomas Burgoyne
Publikováno v:
Cells, Vol 13, Iss 13, p 1100 (2024)
The retinal pigment epithelium (RPE) is an essential component of the retina that plays multiple roles required to support visual function. These include light onset- and circadian rhythm-dependent tasks, such as daily phagocytosis of photoreceptor o
Externí odkaz:
https://doaj.org/article/c2b2460d89ce4685a5d3ae2bdde2d5da
Autor:
Rita Rosado-Ramos, Gonçalo M. Poças, Daniela Marques, Alexandre Foito, David M. Sevillano, Mafalda Lopes-da-Silva, Luís G. Gonçalves, Regina Menezes, Marcel Ottens, Derek Stewart, Alain Ibáñez de Opakua, Markus Zweckstetter, Miguel C. Seabra, César S. Mendes, Tiago Fleming Outeiro, Pedro M. Domingos, Cláudia N. Santos
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-21 (2023)
In this work, the authors identify Genipin as a small iridoid able to prevent alpha-synuclein aggregation and toxicity by affecting endocytosis, metabolism and lipid storage.
Externí odkaz:
https://doaj.org/article/6e0052eb0e2b432c9b02cba0d241c7e9
Publikováno v:
Frontiers in Ophthalmology, Vol 3 (2023)
Inherited retinal diseases (IRDs) encompass a diverse group of genetic disorders that lead to progressive visual impairment and blindness. Over the years, considerable strides have been made in understanding the underlying molecular mechanisms of IRD
Externí odkaz:
https://doaj.org/article/109bec1cdb594ca89268da682f6f34ee
Autor:
Luís C. Cabaço, Liliana Bento-Lopes, Matilde V. Neto, Andreia Ferreira, Wanja B.L. Staubli, José S. Ramalho, Miguel C. Seabra, Duarte C. Barral
Publikováno v:
JID Innovations, Vol 2, Iss 5, Pp 100139- (2022)
Skin pigmentation is imparted by melanin and is crucial for photoprotection against UVR. Melanin is synthesized and packaged into melanosomes within melanocytes and is then transferred to keratinocytes (KCs). Although the molecular players involved i
Externí odkaz:
https://doaj.org/article/a777a26bf9b145d592b5d711486831ff
Autor:
Liliana Bento-Lopes, Luís C. Cabaço, João Charneca, Matilde V. Neto, Miguel C. Seabra, Duarte C. Barral
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 14, p 11289 (2023)
Skin pigmentation ensures efficient photoprotection and relies on the pigment melanin, which is produced by epidermal melanocytes and transferred to surrounding keratinocytes. While the molecular mechanisms of melanin synthesis and transport in melan
Externí odkaz:
https://doaj.org/article/d250ff1453604689aedabc45a6f95411
Autor:
Sarah Batista Dias, Luísa de Lemos, Luís Sousa, Diogo B. Bitoque, Gabriela Araújo Silva, Miguel C. Seabra, Sandra Tenreiro
Publikováno v:
Biomolecules, Vol 13, Iss 1, p 180 (2023)
Alpha-synuclein (aSyn) plays a central role in Parkinson’s disease (PD) and has been extensively studied in the brain. This protein is part of the synuclein family, which is also composed of beta-synuclein (bSyn) and gamma-synuclein (gSyn). In addi
Externí odkaz:
https://doaj.org/article/1aeef5b3072847af878b043285c1d618
Autor:
Rita Flores, Ângela Carneiro, Guilherme Neri, Ana C. Fradinho, Bruno Quenderra, Maria João Barata, Sandra Tenreiro, Miguel C. Seabra
Publikováno v:
Diagnostics, Vol 12, Iss 5, p 1290 (2022)
Age-related macular degeneration (AMD) is a multifactorial disease, whose complete pathogenesis is still unclear. Local hemodynamics may play a crucial role in its manifestation and progression. To evaluate choroidal and retinal vascular parameters,
Externí odkaz:
https://doaj.org/article/5c42b97babd54767ab86d6fa7d82e643
Publikováno v:
PLoS ONE, Vol 15, Iss 11, p e0242284 (2020)
X-linked choroideremia (CHM) is a disease characterized by gradual retinal degeneration caused by loss of the Rab Escort Protein, REP1. Despite partial compensation by REP2 the disease is characterized by prenylation defects in multiple members of th
Externí odkaz:
https://doaj.org/article/9b7735e5702140f4b1e49cb5911d79ad
Publikováno v:
Life, Vol 12, Iss 1, p 36 (2021)
Early and intermediate AMD patients represent a heterogeneous population with an important but variable risk of progression to more advanced stages of the disease. The five-year progression from early and intermediate AMD to late disease is known to
Externí odkaz:
https://doaj.org/article/359ec04ede8f4fd1b9b9a5dd2aab98e9
Autor:
Tatiana Burrinha, César Cunha, Michael J. Hall, Mafalda Lopes‐da‐Silva, Miguel C. Seabra, Cláudia Guimas Almeida
Funding Information: The authors thank the lab members for technical assistance, helpful discussions and for the critical reading of the manuscript. The authors thank Dr. S. Miserey‐Lenkei (Institute Curie), Dr. D. Barral, Dr. O. Vieira and Dr. S.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::daab2b7d4309106adc318333cf107156
https://hdl.handle.net/10362/155155
https://hdl.handle.net/10362/155155
