Zobrazeno 1 - 10
of 12
pro vyhledávání: '"C Scott Wylie"'
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 1, p e1004710 (2016)
The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to applications of these concepts i
Externí odkaz:
https://doaj.org/article/4cc2e798174b4caaac5c1c34919752e6
Autor:
C Scott Wylie, Eugene I Shakhnovich
Publikováno v:
PLoS Computational Biology, Vol 8, Iss 8, p e1002609 (2012)
Reproduction is inherently risky, in part because genomic replication can introduce new mutations that are usually deleterious toward fitness. This risk is especially severe for organisms whose genomes replicate "semi-conservatively," e.g. viruses an
Externí odkaz:
https://doaj.org/article/9ee31c85d5b5474aa9b3d8e2f61906c0
Publikováno v:
PLoS Genetics, Vol 6, Iss 9, p e1001108 (2010)
A phylogenetically diverse subset of bacterial species are naturally competent for transformation by DNA. Transformation entails recombination of genes between different lineages, representing a form of bacterial sex that increases standing genetic v
Externí odkaz:
https://doaj.org/article/03288a248c0048128501fa2f29b3b9f9
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance It has been known since the early days of population genetics that population size plays a critical role in natural selection. In small populations, selection on alleles that intrinsically affect fitness can be overwhelmed by genetic dri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5e77b900f6f5a988ad626341bc713658
https://doi.org/10.1101/157131
https://doi.org/10.1101/157131
Autor:
C. Scott Wylie, Eugene I. Shakhnovich
Publikováno v:
Proceedings of the National Academy of Sciences. 108:9916-9921
Fitness effects of mutations fall on a continuum ranging from lethal to deleterious to beneficial. The distribution of fitness effects (DFE) among random mutations is an essential component of every evolutionary model and a mathematical portrait of r
Autor:
C Brandon, Ogbunugafor, C Scott, Wylie, Ibrahim, Diakite, Daniel M, Weinreich, Daniel L, Hartl
Publikováno v:
PLoS Computational Biology
The adaptive landscape analogy has found practical use in recent years, as many have explored how their understanding can inform therapeutic strategies that subvert the evolution of drug resistance. A major barrier to applications of these concepts i
Publikováno v:
Current opinion in geneticsdevelopment. 23(6)
Natural selection drives evolving populations up the fitness landscape, the projection from nucleotide sequence space to organismal reproductive success. While it has long been appreciated that topographic complexities on fitness landscapes can arise
Publikováno v:
PLoS genetics, vol 6, iss 9
PLoS Genetics
PLoS Genetics, Vol 6, Iss 9, p e1001108 (2010)
PLoS Genetics
PLoS Genetics, Vol 6, Iss 9, p e1001108 (2010)
A phylogenetically diverse subset of bacterial species are naturally competent for transformation by DNA. Transformation entails recombination of genes between different lineages, representing a form of bacterial sex that increases standing genetic v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8faf37d21948fe9d8479a19114fc6a17
https://escholarship.org/uc/item/6jp0n5v5
https://escholarship.org/uc/item/6jp0n5v5
A mutator is an allele that increases the mutation rate throughout the genome by disrupting some aspect of DNA replication or repair. Mutators that increase the mutation rate by the order of 100 fold have been observed to spontaneously emerge and ach
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a41f09ab946e3b2bb5bf0e0c0a975177
https://europepmc.org/articles/PMC2666523/
https://europepmc.org/articles/PMC2666523/
Publikováno v:
Physical Review E. 74
We study two-dimensional (2D) fronts propagating up a comoving reaction rate gradient in finite number reaction-diffusion systems. We show that in a 2D rectangular channel, planar solutions to the deterministic mean-field equation are stable with res