Considerations in the search for epistasis

Autor: Marleen Balvert, Johnathan Cooper-Knock, Julian Stamp, Ross P. Byrne, Soufiane Mourragui, Juami van Gils, Stefania Benonisdottir, Johannes Schlüter, Kevin Kenna, Sanne Abeln, Alfredo Iacoangeli, Joséphine T. Daub, Brian L. Browning, Gizem Taş, Jiajing Hu, Yan Wang, Elham Alhathli, Calum Harvey, Luna Pianesi, Sara C. Schulte, Jorge González-Domínguez, Erik Garrisson, Lorentz workshop on epistasis, Michael P. Snyder, Alexander Schönhuth, Letitia M. F. Sng, Natalie A. Twine

Publikováno v: Genome Biology, Vol 25, Iss 1, Pp 1-17 (2024)

Abstract Epistasis refers to changes in the effect on phenotype of a unit of genetic information, such as a single nucleotide polymorphism or a gene, dependent on the context of other genetic units. Such interactions are both biologically plausible a

Externí odkaz: https://doaj.org/article/b474a576126e4691988acae1b1be2c19

Exploring the genetics of lithium response in bipolar disorders

Autor: Marisol Herrera-Rivero, Mazda Adli, Kazufumi Akiyama, Nirmala Akula, Azmeraw T. Amare, Raffaella Ardau, Bárbara Arias, Jean-Michel Aubry, Lena Backlund, Frank Bellivier, Antonio Benabarre, Susanne Bengesser, Abesh Kumar Bhattacharjee, Joanna M. Biernacka, Armin Birner, Micah Cearns, Pablo Cervantes, Hsi-Chung Chen, Caterina Chillotti, Sven Cichon, Scott R. Clark, Francesc Colom, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Bruno Etain, Peter Falkai, Ewa Ferensztajn-Rochowiak, Andreas J. Forstner, Josef Frank, Louise Frisén, Mark A. Frye, Janice M. Fullerton, Carla Gallo, Sébastien Gard, Julie S. Garnham, Fernando S. Goes, Maria Grigoroiu-Serbanescu, Paul Grof, Ryota Hashimoto, Roland Hasler, Joanna Hauser, Urs Heilbronner, Stefan Herms, Per Hoffmann, Liping Hou, Yi-Hsiang Hsu, Stephane Jamain, Esther Jiménez, Jean-Pierre Kahn, Layla Kassem, Tadafumi Kato, John Kelsoe, Sarah Kittel-Schneider, Po-Hsiu Kuo, Ichiro Kusumi, Barbara König, Gonzalo Laje, Mikael Landén, Catharina Lavebratt, Marion Leboyer, Susan G. Leckband, Mario Maj, Mirko Manchia, Cynthia Marie-Claire, Lina Martinsson, Michael J. McCarthy, Susan L. McElroy, Vincent Millischer, Marina Mitjans, Francis M. Mondimore, Palmiero Monteleone, Caroline M. Nievergelt, Tomas Novák, Markus M. Nöthen, Claire O’Donovan, Norio Ozaki, Sergi Papiol, Andrea Pfennig, Claudia Pisanu, James B. Potash, Andreas Reif, Eva Reininghaus, Hélène Richard-Lepouriel, Gloria Roberts, Guy A. Rouleau, Janusz K. Rybakowski, Martin Schalling, Peter R. Schofield, Klaus Oliver Schubert, Eva C. Schulte, Barbara W. Schweizer, Giovanni Severino, Tatyana Shekhtman, Paul D. Shilling, Katzutaka Shimoda, Christian Simhandl, Claire M. Slaney, Alessio Squassina, Thomas Stamm, Pavla Stopkova, Fabian Streit, Fasil Tekola-Ayele, Anbupalam Thalamuthu, Alfonso Tortorella, Gustavo Turecki, Julia Veeh, Eduard Vieta, Biju Viswanath, Stephanie H. Witt, Peter P. Zandi, Martin Alda, Michael Bauer, Francis J. McMahon, Philip B. Mitchell, Marcella Rietschel, Thomas G. Schulze, Bernhard T. Baune

Publikováno v: International Journal of Bipolar Disorders, Vol 12, Iss 1, Pp 1-11 (2024)

Abstract Background Lithium (Li) remains the treatment of choice for bipolar disorders (BP). Its mood-stabilizing effects help reduce the long-term burden of mania, depression and suicide risk in patients with BP. It also has been shown to have benef

Externí odkaz: https://doaj.org/article/d190709c270e4808ba3f01e9fa533547

THE LONG-TERM SEQUELAE OF TBI IN SURGICAL AND NONSURGICAL CASES

Autor: Wolf-Ingo Steudel, E. Rickels, U. Repschläger, C. Schulte, H. Weissgärber, D. Wende

Publikováno v: Romanian Neurosurgery, Vol 38, Iss Special Issue (2024)

Background The acute effects of traumatic brain Injury (TBI) are well documented but there is no systematic quantification of its long-term sequelae in German-language literature. The purpose of this study is to compare the frequency of conditions

Externí odkaz: https://doaj.org/article/6f8cccc88ac84301be9c10e547f6b1da

Resuscitation room management of patients with non-traumatic critical illness in the emergency department (OBSERvE-DUS-study)

Autor: Janina Dziegielewski, Falko C. Schulte, Christian Jung, Georg Wolff, Oliver Hannappel, Philipp Kümpers, Michael Bernhard, Mark Michael

Publikováno v: BMC Emergency Medicine, Vol 23, Iss 1, Pp 1-10 (2023)

Abstract Background Few studies address the care of critically ill non-traumatic patients in the emergency department (ED). The aim of this study was to assess the epidemiology, management, and outcome of these patients. Methods In this retrospective

Externí odkaz: https://doaj.org/article/cc7f532e51c645d8a40208a73f27ccdd

Comparative serum proteomic analysis of a selected protein panel in individuals with schizophrenia and bipolar disorder and the impact of genetic risk burden on serum proteomic profiles

Autor: Mojtaba Oraki Kohshour, Nirmal R. Kannaiyan, August Jernbom Falk, Sergi Papiol, Urs Heilbronner, Monika Budde, Janos L. Kalman, Eva C. Schulte, Marcella Rietschel, Stephanie Witt, Andreas J. Forstner, Stefanie Heilmann-Heimbach, Markus M. Nöthen, Carsten Spitzer, Berend Malchow, Thorsten Müller, Jens Wiltfang, Peter Falkai, Andrea Schmitt, Moritz J. Rossner, Peter Nilsson, Thomas G. Schulze

Publikováno v: Translational Psychiatry, Vol 12, Iss 1, Pp 1-6 (2022)

Abstract The diagnostic criteria for schizophrenia (SCZ) and bipolar disorder (BD) are based on clinical assessments of symptoms. In this pilot study, we applied high-throughput antibody-based protein profiling to serum samples of healthy controls an

Externí odkaz: https://doaj.org/article/316001b1b48848e78b45c2177c79da72