Potentiation of BCNU antitumor efficacy by 9-substituted O 6-benzylguanines. Effect of metabolism

Autor: S. C. Schold, Anthony E. Pegg, Moschel Rc, Demetrius M. Kokkinakis

Publikováno v: Cancer Chemotherapy and Pharmacology. 45:69-77

Purpose: O6-Benzylguanine (BG), an O6-methylguanine-DNA methyltransferase (MGMT) inactivator, potentiates the efficacy of 1,3-bis(2-chloroethyl)-1-nitrosourea (BCNU) and of other DNA chloroethylating and methylating anticancer drugs and is currently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf985bc603801b4e2f67ec1e70ae0196
https://doi.org/10.1007/pl00006746

Phase I trial of O6-benzylguanine for patients undergoing surgery for malignant glioma

Autor: James M. Pluda, DM Kokkinakis, Robert C. Moschel, ME Dolan, Michael M. Haglund, Henry S. Friedman, Darell D. Bigner, Jeremy N. Rich, Tracy Kerby, Allan H. Friedman, David M. Ashley, Ilkcan Cokgor, James E. Herndon, S. C. Schold, Roger E. McLendon, Anthony E. Pegg

Publikováno v: Journal of Clinical Oncology. 16:3570-3575

PURPOSE The major mechanism of resistance to alkylnitrosourea therapy is the DNA repair protein O6-alkylguanine-DNA alkyltransferase (AGT), which removes chlorethylation or methylation damage from the O6-position of guanine. O6-benzylguanine (O6-BG)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b69dc7850cb4b909803065f9a6f4c3e
https://doi.org/10.1200/jco.1998.16.11.3570

Regulation of O6-methylguanine-DNA methyltransferase by methionine in human tumour cells

Autor: D. M. Kokkinakis, S. C. Schold, Thomas P. Brent, T. H. Vuong, M. A. von Wronski

Publikováno v: British Journal of Cancer

Methionine (MET)-dependent cell lines require MET to proliferate, and homocysteine (HCY) does not act as a substitute for this requirement. From six O6-methylguanine-DNA methyltransferase (MGMT)-efficient (mer+) cell lines tested, two medulloblastoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0b7eb496a425293df85b3abcf359e5c0
http://europepmc.org/articles/PMC2063394

Effects of therapy on the 1H NMR spectrum of a human glioma line

Autor: S. Cazzaniga, S. C. Schold, Henry Dirk Sostman, H. Cecil Charles

Publikováno v: Magnetic Resonance Imaging. 12:945-950

Currently it is difficult to predict the efficacy of any therapeutic modality in individual patients. If it could be shown that successful therapy causes some chemical alteration in the tumor before gross alteration in size becomes radiologically vis

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https://doi.org/10.1016/0730-725x(94)92035-4

Abstracts for the Tenth International Conference on Brain Tumour Research and Therapy

Autor: Tore G. Abrahamsen, Finn Wesenberg, Sverre Mørk, Jeffrey Allen, Roberta Hayes, Robert DaRosso, Anita Nirenberg, Francis Ali-Osman, Nike Akande, V. Amberger, H. Seulberger, P. A. Paganetti, M. E. Schwab, N. Arita, T. Ohnishi, S. Hiraga, H. Yamamoto, T. Taki, S. Izumoto, M. Higuchi, T. Hayakawa, M. Kusakabe, T. Sakakura, N. G. Baldwin, C. D. Rice, R. E. Merchant, Sally M. Ashmore, J. L. Darling, C. C. Bailey, C. Balmaceda, B. Diez, J. Villablanca, R. Walker, J. Finlay, A. Tommy Bergenheim, Magdalena Hartman, Jonas Bergh, PerÅke Ridderheim, Roger Henriksson, Michael E. Berens, Monique D. Rief, Alf Giese, Björn Zackrisson, Jörgen Elfversson, Mark Bernstein, Alberto Cabantog, Jennifer Glen, David Mikulis, Rolf Bjerkvig, Paal-Henning Pedersen, Berit Mathisen, Rupavathana Mahesparan, Hans Kristian Haugland, Normand Laperriere, Cindy Thomason, Phil Leung, M. S. Bobola, M. S. Berger, J. R. Silber, Erik Bongcam-Rudloff, Jia-Lun Wang, Monica Nistér, Bengt Westermark, Steven Brem, Gary Breslow, Jason Ho, Stephen Gately, Shingo Takano, William Ward, M. Brada, R. Laing, J. Warrington, Herbert Engelhard, Barry Landau, Hau Kwaan, Elaine Verrusio, J. C. Buckner, T. L. Cascino, P. S. Schomberg, J. R. O'Fallon, R. P. Dinapoli, P. A. Burch, E. G. Shaw, William C. Broaddus, Kathryn Hager-Loudon, Randall E. Merchant, William Loudon, William T. Couldwell, Jack B. Jiang, David Burns, Martin H. Weiss, Michael L. J. Apuzzo, I. Desbaillets, M. Tada, N. de Tribolet, E. Van Meir, R. L. Davis, K. Onda, M. D. Prados, M. Eileen Dolan, Matthew J. Fleig, Henry S. Friedman, A. Jonas Ekstrand, Nicola Longo, C. David James, D. Chou, B. Wijnhoven, M. Bellinzona, M. Nakagawa, B. G. Feuerstein, H. S. Basu, M. E. Dolan, C. Bergeron, M. Pellarm, D. F. Deen, L. J. Marton, Jonathan Finlay, D. S. Fulton, R. C. Urtasun, Adrienne C. Scheck, J. Geddes, G. M. Vowles, S. M. Ashmore, G. Y. Gillespie, C. K. Goldman, M. T. Tucker, E. Lyon, J. -C. Tsai, G. T. Gobbel, P. H. Chan, Hairy S. Greenberg, W. F. Chandler, W. D. Ensminger, L. Junck, H. Sandler, J. Bromberg, P. McKeever, G. G. Gonzalez, A. Sarkar, H. Basu, Kr. Haugland, Ole-Bjørn Tysnes, Shoju Hiraga, Norio Arita, Takanori Ohnishi, Takuyu Taki, Hiroshi Yamamoto, Masahide Higuchi, Toru Hayakawa, Erik Isern, Geirmund Unsgaard, Anne Beate Langeland Marthinsen, Trond Strickert, Eirik Helseth, F. Hochberg, R. Cosgrove, R. Valenzuela, F. Pardo, N. Zervas, Robert B. Jenkins, Steven R. Ritland, Kevin C. Hailing, Stephen N. Thibodeau, L. Juillerat, P. Darekar, R. C. Janzer, M. F. Hamou, Tsutomu Kato, Yutaka Sawamura, Mitsuhiro Tada, Shirou Sakuma, Masako Sudo, Hiroshi Abe, M. Kallio, J. Leppää, T. Nikula, P. Nikkinen, H. Gylling, M. Färkkilä, J. Hiltunen, J. Jääskeläinen, K. Liewendahl, G. Evren Keles, Mitchel S. Berger, Anna Deliganis, S. J. Kellie, S. S. N. De Graaf, H. Bloemhof, I. Johnston, D. D. R. Uges, M. Besser, R. W. Chaseling, R. A. Ouvrier, N. D. Kitchen, S. Hughes, R. Beaney, D. G. T. Thomas, D. H. Kim, T. Maeda, G. Mohapatra, S. Park, F. W. Waldman, J. W. Gray, D. Koala, J. Silber, M. Berger, P. Krauseneck, B. Müller, H. Strik, M. Warmuth-Metz, Jun-ichi Kuratsu, Hideo Takeshima, Yukitaka Ushio, C. Kretschmar, H. Grodman, R. Linggood, A. P. Kyritsis, M. Bondy, J. Cunningham, M. Xiao, V. Levin, N. Leeds, J. Bruner, W. K. A. Yung, H. Saya, L. A. Lampson, M. R. Nichols, M. A. Lampson, A. D. Dunne, Hong Li, Marie-France Hamou, Rehana Jaufeerally, Annie-Claire Diserens, Erwin Van Meir, Nicolas de Tribolet, V. A. Levin, M. Maor, R. Sawaya, M. Leavens, S. Woo, P. Thall, M. J. Gleason, Bertrand C. Liang, D. A. Ross, P. S. Meltzer, J. M. Trent, H. S. Greenberg, K. O. Lillehei, Q. Kong, B. K. DeMasters, S. J. Withrow, D. R. Macdonald, J. G. Cairncross, S. Ludwin, D. Lee, T. Cascino, J. Buckner, E. Dropcho, D. Fulton, D. Stewart, C. Schold, N. Wainman, E. Eisenhauer, S. Kirby, B. J. Fisher, L. Magrassi, G. Butti, S. Pezzotta, G. Milanesi∘, Masao Matsutani, Kirsten Marienhagen, Ole Didrik Laerum, Abderrahim Merzak, Shahriar Koocheckpour, Yannis Roxanis, Geoffrey J. Pilktngton, Masakatsu Nagai, Kunihiko Watanabe, Jun-ichi Narita, Hideaki Hagiwara, Mark Noble, K. Nomura, H. Oyama, M. Motoo, S. Shibui, K. Tokuue, Y. Akine, Svein J. Tjoflaat Nygaard, F. S. Pardo, D. W. Hsu, E. T. Hedley-Whyte, J. Efird, E. V. Schmidt, Paal-Henning Pedersenl Kirsten Marienhagen, Geoffrey J. Pilkington, Tracey M. Clarke, Hui Tian Yu, Joan P. Rogers, Robert Stern, Surasak Phuphanich, Harvey Greenberg, R. Murtagh, Jesus Viloria, Joseph Ransohoff, Kimberly Martin, V. Erika Hatva, Jasti S. Rao, S. Mohanam, Sandra A. Rempel, Karl Schwechheimer, Richard L. Davis, Webster K. Cavenee, Mark L. Rosenblum, Guido Reifenberger, Lu Liu, Koichi Ichimura, Esther E. Schmidt, V. Peter Collins, T. Revesz, F. Scaravilli, H. Cockburn, R. T. Biron, James McKerrow, Bonnie Sloane, Tom Mikkelsen, Norbert Roosen, Peter Coopersmith, Robert Smith, Harcharan Kaur Rooprai, Steven Maidment, Garry Rucklidge, Anton Volovsek, J. T. Rutka, S. L. Smith, K. Matsuzawa, A. A. Sankar, S. R. Williams, K. Fukuyama, Jun Ikeda, R. G. Selker, F. T. Vertosick, M. T. Goldenberg, R. Bindal, A. Taratuto, P. Picco, J. Monges, M. Martinez, G. Pacheco, M. Gamboni, M. Schultz, B. A. Mueller, T. G. Ewers, T. Shiraishi, K. Tabuchi, S. Nakagawa, S. Kihara, D. J. Stewart, L. Eapen, O. Agboola, P. Popovic, R. Goel, P. Raaphorst, P. T. T. Wong, S. Shimokawa, M. Oh-uchida, K. Hori, C. Markert, K. -W. Pflughaupt, A. -C. Diserens, R. Jauferrally, M. -F. Hamou, H. Takeshima, H. Mochizuki, J. L. Clifford, T. Nishi, R. Lotan, A. J. A. Terzis, H. Arnold, O. D. Laerum, R. Bjerkvig, A. L. Taratuto, G. Sevlever, D. Diaz, M. Di Tella, V. Cuccia, H. Pomata, G. Gallo, A. Dietze, U. Knopp, R. Thomas, P. Carnochan, G. Flux, N. Kitchen, D. Thomas, M. Zalutsky, D. Bigner, Philip Tofilon, Paul Borchardt, Sverre H. Torp, Are Dalen, Takashi Tohyama, Osami Kubo, Kintomo Takakura, Virginia M. -Y. Lee, John Q. Trojanowski, Svein Nygaard, M. B. Parliament, A. J. McEwan, R. H. Mannan, L. I. Weibe, G. Unsgårp, U. Sonnewald, I. Gribbestad, E. Isern, S. B. Petersen, J. Wang, D. A. Delgado, Tracy J. Warr, Denise Sheer, Pat Gorman, F. Yamaguchi, M. Westphal, L. Anker, W. Hamel, M. Lücke, M. Shepard, P. Kleihues, H. D. Herrmann, W. K. Alfred Yung, Scott Taylor, Peter A. Steck

Publikováno v: Journal of Neuro-Oncology. 15:S1-S30

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a141616716109a67579948bafa65b590
https://doi.org/10.1007/bf02041900