Zobrazeno 1 - 10
of 67
pro vyhledávání: '"C Savio, Chan"'
Autor:
Marie A. Labouesse, Arturo Torres-Herraez, Muhammad O. Chohan, Joseph M. Villarin, Julia Greenwald, Xiaoxiao Sun, Mysarah Zahran, Alice Tang, Sherry Lam, Jeremy Veenstra-VanderWeele, Clay O. Lacefield, Jordi Bonaventura, Michael Michaelides, C. Savio Chan, Ofer Yizhar, Christoph Kellendonk
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract In the classical model of the basal ganglia, direct pathway striatal projection neurons (dSPNs) send projections to the substantia nigra (SNr) and entopeduncular nucleus to regulate motor function. Recent studies have re-established that dSP
Externí odkaz:
https://doaj.org/article/81d980c17c3448e59ac7e2551e221f37
Autor:
Harry S. Xenias, Chuyu Chen, Shuo Kang, Suraj Cherian, Xiaolei Situ, Bharanidharan Shanmugasundaram, Guoxiang Liu, Giuseppe Scesa, C. Savio Chan, Loukia Parisiadou
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-14 (2022)
Abstract LRRK2 mutations are closely associated with Parkinson’s disease (PD). Convergent evidence suggests that LRRK2 regulates striatal function. Here, by using knock-in mouse lines expressing the two most common LRRK2 pathogenic mutations—G201
Externí odkaz:
https://doaj.org/article/0a23718f268548469f30d522e7f56b2e
Autor:
Guadalupe Rodriguez, Daniel W. Fisher, Bryan McClarty, Janitza Montalvo-Ortiz, Qiaoling Cui, C. Savio Chan, Hongxin Dong
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2023)
Antipsychotic drugs are still widely prescribed to control various severe neuropsychiatric symptoms in the elderly and dementia patients although they are off-label use in the United States. However, clinical practice shows greater side effects and l
Externí odkaz:
https://doaj.org/article/89530f9c5c49421ab2118e458644fa92
Autor:
Luis Carrillo-Reid, Michelle Day, Zhong Xie, Alexandria E Melendez, Jyothisri Kondapalli, Joshua L Plotkin, David L Wokosin, Yu Chen, Geraldine J Kress, Michael Kaplitt, Ema Ilijic, Jaime N Guzman, C Savio Chan, D James Surmeier
Publikováno v:
eLife, Vol 8 (2019)
Huntington’s disease (HD) is initially characterized by an inability to suppress unwanted movements, a deficit attributable to impaired synaptic activation of striatal indirect pathway spiny projection neurons (iSPNs). To better understand the mech
Externí odkaz:
https://doaj.org/article/6d433a31aa0f4103a04bf72732b8b59c
Autor:
Connor D. Courtney, C. Savio Chan
Publikováno v:
Trends in Neurosciences. 46:336-337
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7293b80993dd36ed48065e6912b4120e
https://doi.org/10.1016/j.tins.2023.03.002
https://doi.org/10.1016/j.tins.2023.03.002
Autor:
Gessynger Morais-Silva, Rianne R. Campbell, Hyungwoo Nam, Mahashweta Basu, Marco Pagliusi, Megan E. Fox, C. Savio Chan, Sergio D. Iñiguez, Seth Ament, Nathan Cramer, Marcelo Tadeu Marin, Mary Kay Lobo
Publikováno v:
The Journal of neuroscience : the official journal of the Society for Neuroscience.
Altered activity of the ventral pallidum (VP) underlies disrupted motivation in stress and drug exposure. The VP is a very heterogeneous structure composed of many neuron types with distinct physiological properties and projections. Neuronal PAS 1-po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::55cda8de7d763a4704ea2c93a389b1d7
https://pubmed.ncbi.nlm.nih.gov/36443000
https://pubmed.ncbi.nlm.nih.gov/36443000
Autor:
Simina M. Boca, Saivasudha Chalasani, Talia N. Lerner, Harry S. Xenias, Isabel Fan, Adam W. Hantman, Arin Pamukcu, Qiaoling Cui, Brianna L. Berceau, Elizabeth C. Augustine, C. Savio Chan
Publikováno v:
The Journal of Neuroscience. 40:7855-7876
The external globus pallidus (GPe) is a critical node within the basal ganglia circuit. Phasic changes in the activity of GPe neurons during movement and their alterations in Parkinson's disease (PD) argue that the GPe is important in motor control.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7bb8c55988524eae65db6efe222234c0
https://doi.org/10.1523/jneurosci.0361-20.2020
https://doi.org/10.1523/jneurosci.0361-20.2020
Publikováno v:
J Neurophysiol
Neurons in the external globus pallidus (GPe) are autonomous pacemakers, but their spontaneous firing is continually perturbed by synaptic input. Because GPe neurons fire rhythmically in slices, spontaneous inhibitory synaptic currents (IPSCs) should
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e1a7d1383b6defd8413bdd49723f491
https://pubmed.ncbi.nlm.nih.gov/33729831
https://pubmed.ncbi.nlm.nih.gov/33729831
Autor:
Byung Kook Lim, Xixun Du, Uree Chon, Ahana Narayanan, Darius Hong, Brianna L. Berceau, Varoth Lilascharoen, Arin Pamukcu, Isaac Y. M. Chang, C. Savio Chan, Yongsoo Kim, Daniela García, Qiaoling Cui
The classic basal ganglia circuit model asserts a complete segregation of the two striatal output pathways. Empirical data argue that, in addition to indirect-pathway striatal projection neurons (iSPNs), direct-pathway striatal projection neurons (dS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fade016bef86fcab1e41e5e48967404b
https://doi.org/10.1101/2020.09.02.273615
https://doi.org/10.1101/2020.09.02.273615
Autor:
Qiaoling, Cui, Xixun, Du, Isaac Y M, Chang, Arin, Pamukcu, Varoth, Lilascharoen, Brianna L, Berceau, Daniela, García, Darius, Hong, Uree, Chon, Ahana, Narayanan, Yongsoo, Kim, Byung Kook, Lim, C Savio, Chan
Publikováno v:
J Neurosci
The classic basal ganglia circuit model asserts a complete segregation of the two striatal output pathways. Empirical data argue that, in addition to indirect-pathway striatal projection neurons (iSPNs), direct-pathway striatal projection neurons (dS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::306cf6c064a1d2475eae24905f13e82f
https://pubmed.ncbi.nlm.nih.gov/33731445
https://pubmed.ncbi.nlm.nih.gov/33731445