Zobrazeno 1 - 10
of 1 350
pro vyhledávání: '"C Sadler"'
Publikováno v:
Genome Biology, Vol 25, Iss 1, Pp 1-24 (2024)
Abstract Background Telomeres form repeated DNA sequences at the ends of chromosomes, which shorten with each cell division. Yet, factors modulating telomere attrition and the health consequences thereof are not fully understood. To address this, we
Externí odkaz:
https://doaj.org/article/c65c7c7666ae4dff87fa410c20257de2
Autor:
Chiara Auwerx, Maarja Jõeloo, Marie C. Sadler, Nicolò Tesio, Sven Ojavee, Charlie J. Clark, Reedik Mägi, Estonian Biobank Research Team, Alexandre Reymond, Zoltán Kutalik
Publikováno v:
Genome Medicine, Vol 16, Iss 1, Pp 1-24 (2024)
Abstract Background Copy-number variations (CNVs) have been associated with rare and debilitating genomic disorders (GDs) but their impact on health later in life in the general population remains poorly described. Methods Assessing four modes of CNV
Externí odkaz:
https://doaj.org/article/99204a983c254d6594fd32cb0289dd83
Publikováno v:
Biology Open, Vol 13, Iss 3 (2024)
Externí odkaz:
https://doaj.org/article/8ca1d670f0074cb8aa263b143c233f16
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
The mechanism by which DNA methylation might affect complex traits is not well understood. Here, the authors use Mendelian randomization to reveal a substantial role of transcript levels in mediating DNA methylation effects on complex traits and dise
Externí odkaz:
https://doaj.org/article/c2be3825597345b584bbf11cfe5a34d5
Publikováno v:
BMC Biology, Vol 20, Iss 1, Pp 1-23 (2022)
Abstract Background Epigenetic regulatory mechanisms are divergent across the animal kingdom, yet these mechanisms are not well studied in non-model organisms. Unique features of cephalopods make them attractive for investigating behavioral, sensory,
Externí odkaz:
https://doaj.org/article/db0c9e7d7e274f03afd6150fdfc215a2
Autor:
Bryan J. Killinger, Christopher Whidbey, Natalie C. Sadler, Adrian J. DeLeon, Nathalie Munoz, Young-Mo Kim, Aaron T. Wright
Publikováno v:
npj Biofilms and Microbiomes, Vol 8, Iss 1, Pp 1-10 (2022)
Abstract While deprivation of dietary fiber has been associated with adverse health outcomes, investigations concerning the effect of dietary fiber on the gut microbiome have been largely limited to compositional sequence-based analyses or utilize a
Externí odkaz:
https://doaj.org/article/bc65aa0687a3432ca6dad29598eb4b9e
Autor:
Giuliana Giannuzzi, Nicolas Chatron, Katrin Mannik, Chiara Auwerx, Sylvain Pradervand, Gilles Willemin, Kendra Hoekzema, Xander Nuttle, Jacqueline Chrast, Marie C. Sadler, Eleonora Porcu, p11.2 Consortium, Yann Herault, Bertrand Isidor, Brigitte Gilbert-Dussardier, Evan E. Eichler, Zoltan Kutalik, Alexandre Reymond
Publikováno v:
npj Genomic Medicine, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Recurrent copy-number variations (CNVs) at chromosome 16p11.2 are associated with neurodevelopmental diseases, skeletal system abnormalities, anemia, and genitourinary defects. Among the 40 protein-coding genes encompassed within the rearran
Externí odkaz:
https://doaj.org/article/46886538723645c79e39a958f7052132
Autor:
Chiara Auwerx, Marie C Sadler, Tristan Woh, Alexandre Reymond, Zoltán Kutalik, Eleonora Porcu
Publikováno v:
eLife, Vol 12 (2023)
Despite the success of genome-wide association studies (GWASs) in identifying genetic variants associated with complex traits, understanding the mechanisms behind these statistical associations remains challenging. Several methods that integrate meth
Externí odkaz:
https://doaj.org/article/e62e238f342d4c918033300bce3ce0af
Autor:
Kirsten C. Sadler
Publikováno v:
Disease Models & Mechanisms, Vol 16, Iss 2 (2023)
Externí odkaz:
https://doaj.org/article/2191d8f7a6a3453e824a601d6e33e6d3
Publikováno v:
Cambridge Prisms: Precision Medicine, Vol 1 (2023)
Pharmacogenetics, the study of how interindividual genetic differences affect drug response, does not explain all observed heritable variance in drug response. Epigenetic mechanisms, such as DNA methylation, and histone acetylation may account for so
Externí odkaz:
https://doaj.org/article/3004e3bfe00d426ab1348b4eab52dc41