Výsledky vyhledávání - "C S, Swindell"

3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin

Autor: Israel Ringel, George A. Orr, Susan Band Horwitz, N. E. Krauss, J. M. Heerding, C. S. Swindell, Srinivasa K. Rao

Publikováno v: Journal of Biological Chemistry. 269:3132-3134

Taxol possesses an unusual chemical structure, a unique mechanism of action, and demonstrated activity in human malignancies. It is the only antitumor agent that has a binding site on the microtubule polymer. The interaction of Taxol with the microtu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8d7195a776a061ee3ac931865bead904
https://doi.org/10.1016/s0021-9258(17)41836-9

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Tumor targeting by covalent conjugation of a natural fatty acid to paclitaxel

Autor: M O, Bradley, N L, Webb, F H, Anthony, P, Devanesan, P A, Witman, S, Hemamalini, M C, Chander, S D, Baker, L, He, S B, Horwitz, C S, Swindell

Publikováno v: Clinical cancer research : an official journal of the American Association for Cancer Research. 7(10)

Certain natural fatty acids are taken up avidly by tumors for use as biochemical precursors and energy sources. We tested in mice the hypothesis that the conjugation of docosahexaenoic acid (DHA), a natural fatty acid, and an anticancer drug would cr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::555f9c998945b789db175f7735df72c6
https://pubmed.ncbi.nlm.nih.gov/11595719

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Conformational studies of paclitaxel analogs modified at the C-2' position in hydrophobic and hydrophilic solvent systems

Autor: G, Moyna, H J, Williams, A I, Scott, I, Ringel, R, Gorodetsky, C S, Swindell

Publikováno v: Journal of medicinal chemistry. 40(20)

The conformations of two paclitaxel analogs modified at the C-2' position, 2'-deoxypaclitaxel and 2'-methoxypaclitaxel, were studied in hydrophobic and hydrophilic solvent systems by a combination of NMR spectroscopy, CD measurements, and molecular m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::658e81c5f768eaefd581f440a8ec7d5a
https://pubmed.ncbi.nlm.nih.gov/9379451

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Relationship between the structure of taxol and other taxanes on induction of tumor necrosis factor-alpha gene expression and cytotoxicity

Autor: C A, Burkhart, J W, Berman, C S, Swindell, S B, Horwitz

Publikováno v: Cancer research. 54(22)

Taxol is an antitumor drug with cytotoxic properties that correlate with its microtubule-stabilizing activities. It has been reported that taxol parallels lipopolysaccharide in its effects on the induction of tumor necrosis factor-alpha (TNF-alpha) g

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::9036bdb3ec3adc22ba11a39b79e604bc
https://pubmed.ncbi.nlm.nih.gov/7954398

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3'-(p-azidobenzamido)taxol photolabels the N-terminal 31 amino acids of beta-tubulin

Autor: S, Rao, N E, Krauss, J M, Heerding, C S, Swindell, I, Ringel, G A, Orr, S B, Horwitz

Publikováno v: The Journal of biological chemistry. 269(5)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d41cfeca24403437c3ff3646a203c6a7
https://pubmed.ncbi.nlm.nih.gov/7906266

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Poststroke depression: neurologic, physiologic, diagnostic, and treatment implications

Autor: C S, Swindell, J A, Hammons

Publikováno v: Journal of speech and hearing research. 34(2)

Poststroke depression is a serious disorder that can compromise the overall rehabilitative process, including speech-language treatment. To provide patients with the maximum opportunity for recovery and therapeutic gains, speech-language pathologists

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::c694f1d9ab903108f0fb5dbd3f32eb82
https://pubmed.ncbi.nlm.nih.gov/2046356

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