Zobrazeno 1 - 3
of 3
pro vyhledávání: '"C S, Seckel"'
Publikováno v:
Inhalation Toxicology. 2:285-294
Biotransformation is often a determinant of pharmacokinetic behavior and toxicity. While the liver is usually the quantitatively most significant site, metabolism in other tissues may cause nonhepatic toxicity and also may affect the pharmacokinetic
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::03639736a00b5349c1ef609b87a55d5c
https://doi.org/10.3109/08958379009145259
https://doi.org/10.3109/08958379009145259
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 24(12)
Chloral hydrate (CH) and its metabolites, trichloroacetate (TCA) and dichloroacetate (DCA), have been shown to induce liver tumors in male B6C3F1 mice. The pharmacokinetics of CH and its metabolites play an important role in its toxicity. This study
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::83e33028e8c9559d7e336b331a831e78
https://pubmed.ncbi.nlm.nih.gov/8971140
https://pubmed.ncbi.nlm.nih.gov/8971140
Publikováno v:
Fundamental and applied toxicology : official journal of the Society of Toxicology. 18(4)
The hydraulic fluid oil polychlorotrifluoroethylene (PCTFE) is hepato- and nephrotoxic in the rat. Male Fischer 344 rats were exposed to PCTFE either for a single 6-hr exposure (0.5 or 0.25 mg/liter) or daily 5 days/week, 6 hr/day, for 13 weeks (0.5,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ce2d649fd0403258abd9977c29066088
https://pubmed.ncbi.nlm.nih.gov/1526362
https://pubmed.ncbi.nlm.nih.gov/1526362