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Metabolism of 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2 (1H)-one (L-696,229), an HIV-1 reverse transcriptase inhibitor, by rat liver slices and in humans

Autor: S K, Balani, L R, Kauffman, B H, Arison, T V, Olah, M E, Goldman, S L, Varga, J A, O'Brien, H G, Ramjit, C S, Rooney, J M, Hoffman

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 22(2)

Healthy subjects were administered single oral doses of 800 mg or 400 mg 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-o ne (L-696,229), a nonnucleoside inhibitor of the human immunodeficiency virus-type 1 (HIV-1) reverse transcriptase (

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::1f3b05f830da12a350553ba86539a964
https://pubmed.ncbi.nlm.nih.gov/7516852

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Metabolism of a new HIV-1 reverse transcriptase inhibitor, 3-[2-(benzoxazol-2-yl)ethyl]-5-ethyl-6-methylpyridin-2(1H)-one (L-696,229), in rat and liver slices

Autor: S K, Balani, S M, Pitzenberger, L R, Kauffman, B H, Arison, H G, Ramjit, M E, Goldman, J A, O'Brien, J D, King, J M, Hoffman, C S, Rooney

Publikováno v: Drug metabolism and disposition: the biological fate of chemicals. 20(6)

L-696,229 is a potent and specific inhibitor of human immunodeficiency virus type 1 (HIV-1) reverse transcriptase and is currently undergoing clinical evaluation. In vivo metabolism in rats was investigated using an intravenous bolus dose of 5 mg/kg

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::ed22e357665c8d065cdb1964709980dd
https://pubmed.ncbi.nlm.nih.gov/1283569

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Akademický článek

Divergent and Nucleophile-Assisted Rearrangement in the Construction of Pyrrolo[2,1-b][3]benzazepine and Pyrido[2,1-a]isoquinoline Scaffolds.

Autor: Obydennik AY; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation., Titov AA; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation., Listratova AV; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation., Borisova TN; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation., Sokolova IL; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation., Rybakov VB; Department of Chemistry, Lomonosov Moscow State University, Leninskie Gory, 1-3, Moscow, 119991, Russian Federation., Van der Eycken EV; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation.; Laboratory for Organic & Microwave-Assisted Chemistry (LOMAC), Department of Chemistry, University of Leuven (KU Leuven), Celestijnenlaan 200F, Leuven, 3001, Belgium., Voskressensky LG; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation., Varlamov AV; Organic Chemistry Department, Science Faculty, Рeoples' Friendship University of Russia (RUDN University), 6 Miklukho-Maklaya St, Moscow, 117198, Russian Federation.

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany) [Chemistry] 2024 Jan 11; Vol. 30 (3), pp. e202302919. Date of Electronic Publication: 2023 Nov 20.

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Akademický článek

Transdiagnostic psychosocial interventions to promote mental health in forcibly displaced persons: a systematic review and meta-analysis.

Autor: Schäfer, Sarah K.¹ (AUTHOR) sarah.schaefer@lir-mainz.de, Kunzler, Angela M.^1,2 (AUTHOR), Lindner, Saskia³ (AUTHOR), Broll, Jan¹ (AUTHOR), Stoll, Marlene^1,4 (AUTHOR), Stoffers-Winterling, Jutta^1,3 (AUTHOR), Lieb, Klaus^1,3 (AUTHOR)

Publikováno v: European Journal of Psychotraumatology. 2023, Vol. 14 Issue 2, p1-26. 26p.

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3,4-Dihydro-2H-1,5-benzodioxepins. A Novel Class of β-Adrenergic Stimulants

Autor: B. K. Wasson, Haydn W. R. Williams, R. S. Stuart, C. S. Rooney

Publikováno v: Canadian Journal of Chemistry. 53:2279-2292

A series of 3-substituted-aminomethy1-3-hydroxy-3,4-dihydro-2H-1,5-benzodioxepins is described. Members of the series constitute a unique class of β-adrenergic stimulants and possess interesting bronchial dilator activity.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::54de5f3615863b003a8a3d0b54e4db81
https://doi.org/10.1139/v75-320

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2-(2-Oxo-1-phthalimidoethylidenyl)-1,3-dithiolane. An Unexpected Product from an Attempted Cleavage of a Dithiolane with Ceric Ammonium Nitrate

Autor: C. S. Rooney, H. W. R. Williams

Publikováno v: Synthetic Communications. 7:201-213

Currently, there is considerable interest in the synthesis of peptide derivatives bearing an aldehyde at the C-terminal position in place of the carboxyl group1,2. This interest may have arisen from, and been intensified by, the identification of sev

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::530a4011deb0e03cd63bf0b6f97ccee2
https://doi.org/10.1080/00397917708050737

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