Zobrazeno 1 - 10
of 33
pro vyhledávání: '"C S, Morrow"'
Autor:
K. A. Pickin, Ronald A. Fleming, C. S. Morrow, Susan L. Morris-Natschke, Gregory L. Kucera, K. S. Ishaq, Richard L. Alexander
Publikováno v:
Journal of Drug Delivery Science and Technology. 19:31-36
We synthesized thioether phospholipid carrier molecules, conjugated each of them to 1-b-D-arabinofuranosylcytosine (ara-C), and synthesized amido containing phospholipid carriers conjugated to gemcitabine. Changing the alkyl chain at the C1- and C2-p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::efda506c7d700c26d289ff1212c415f3
https://doi.org/10.1016/s1773-2247(09)50004-4
https://doi.org/10.1016/s1773-2247(09)50004-4
Publikováno v:
Cancer research. 61(14)
We examined the role of multidrug resistance protein (MRP) 1 (ABCC1) in the emergence of mitoxantrone (MX) cross-resistance in a MCF7 breast cancer cell line selected for resistance to etoposide. The resistant cell line, MCF7/VP, expresses high level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::7c2e32a04f876fae1d3526a2a4e0013f
https://pubmed.ncbi.nlm.nih.gov/11454692
https://pubmed.ncbi.nlm.nih.gov/11454692
Publikováno v:
The Journal of biological chemistry. 276(11)
We investigated the role of phase II (conjugation) and phase III (efflux) detoxification of the anticancer drugs melphalan (MLP) and chlorambucil (CHB). Although both drugs are substrates of Alpha-class glutathione S-transferases (GST) and the monogl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::52d9b127ddf8d789a32bdc9dab266277
https://pubmed.ncbi.nlm.nih.gov/11115505
https://pubmed.ncbi.nlm.nih.gov/11115505
Publikováno v:
Molecular carcinogenesis. 29(3)
Previous studies in our laboratory have shown that the phase III efflux transporter multidrug-resistance protein (MRP)1 can act synergistically with the phase II conjugating glutathione S-transferases (GST) to confer resistance to the toxicities of s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::117116aba320201cf1d25ad4141373d4
https://pubmed.ncbi.nlm.nih.gov/11108662
https://pubmed.ncbi.nlm.nih.gov/11108662
Publikováno v:
The Journal of biological chemistry. 273(32)
To examine the role of multidrug resistance protein 1 (MRP1) and glutathione S-transferases (GSTs) in cellular resistance to antineoplastic drugs, derivatives of MCF7 breast carcinoma cells were developed that express MRP1 in combination with one of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::bcb461418e32ea00e5fa3d2a31ca8a5c
https://pubmed.ncbi.nlm.nih.gov/9685354
https://pubmed.ncbi.nlm.nih.gov/9685354
Publikováno v:
Chemico-biological interactions.
The authors have shown that expression of mGSTM1-1 or hGSTP1-1 in MCF-7 cells protects against DNA alkylation by 4-nitroquinoline-1-oxide (NQO) in an isozyme-specific manner and is commensurate with relative specific activity. Expression of GSTs also
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::76eb8215e3c4410f4cb2af4f9b27546a
https://pubmed.ncbi.nlm.nih.gov/9679569
https://pubmed.ncbi.nlm.nih.gov/9679569
Publikováno v:
The Journal of biological chemistry. 269(14)
We investigated the mechanism of sodium butyrate (NaB)-mediated induction of mdr1 mRNA in parental (wild type) and multidrug-resistant (Ad1000) SW620 colon cancer cell lines. NaB treatment resulted in reversible, time-dependent increases in nuclear r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::291296a168e9f27f45be5d07c81e54a5
https://pubmed.ncbi.nlm.nih.gov/7908296
https://pubmed.ncbi.nlm.nih.gov/7908296
Publikováno v:
Cancer chemotherapy and biological response modifiers. 15
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid_dedup__::d51d8b62b40633dbc8a871c2b20a1c60
https://pubmed.ncbi.nlm.nih.gov/7779609
https://pubmed.ncbi.nlm.nih.gov/7779609
Publikováno v:
The Journal of biological chemistry. 268(11)
The human mdr1 gene encodes a putative drug efflux pump (P-glycoprotein) whose overexpression is associated with the development of multidrug resistance (MDR). The promoter and 5'-flanking DNA of this gene were isolated from a human genomic DNA libra
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f41b0cce2d04b517ccd3252eb830d861
https://pubmed.ncbi.nlm.nih.gov/8096520
https://pubmed.ncbi.nlm.nih.gov/8096520
Publikováno v:
The Journal of biological chemistry. 268(8)
Basal transcription of the human multidrug resistance (mdr1) promoter was studied by chloramphenicol acetyltransferase (CAT) reporter fusion gene analysis in two parental and doxorubicin-resistant human tumor cell lines. Deletion of mdr1 DNA sequence
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::e29336711eaa8e7332cbe49490b6099b
https://pubmed.ncbi.nlm.nih.gov/8095499
https://pubmed.ncbi.nlm.nih.gov/8095499