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Akademický článek

Carbon isotopes of dissolved inorganic carbon reflect utilization of different carbon sources by microbial communities in two limestone aquifer assemblages

Autor: M. E. Nowak, V. F. Schwab, C. S. Lazar, T. Behrendt, B. Kohlhepp, K. U. Totsche, K. Küsel, S. E. Trumbore

Publikováno v: Hydrology and Earth System Sciences, Vol 21, Pp 4283-4300 (2017)

Isotopes of dissolved inorganic carbon (DIC) are used to indicate both transit times and biogeochemical evolution of groundwaters. These signals can be complicated in carbonate aquifers, as both abiotic (i.e., carbonate equilibria) and biotic fact

Externí odkaz: https://doaj.org/article/8da57cd90ae14b5d80ba54154dcfb4ec

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A mutant epidermal growth factor receptor common in human glioma confers enhanced tumorigenicity

Autor: C S Lazar, H. J. S. Huang, Gordon N. Gill, R Nishikawa, Webster K. Cavenee, Xiang-Dong Ji, R C Harmon

Publikováno v: Proceedings of the National Academy of Sciences. 91:7727-7731

The development and neoplastic progression of human astrocytic tumors appears to result through an accumulation of genetic alterations occurring in a relatively defined order. One such alteration is amplification of the epidermal growth factor recept

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::862e1e97c0ac760014a2b8d1666e5bfa
https://doi.org/10.1073/pnas.91.16.7727

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Ligand-induced internalization and increased cell calcium are mediated via distinct structural elements in the carboxyl terminus of the epidermal growth factor receptor

Autor: C P, Chang, J P, Kao, C S, Lazar, B J, Walsh, A, Wells, H S, Wiley, G N, Gill, M G, Rosenfeld

Publikováno v: The Journal of biological chemistry. 266(34)

Signals that can mediate ligand-induced receptor internalization and calcium regulation are present in a 48-amino acid "calcium-internalization" domain in the C' terminus of the epidermal growth factor (EGF) receptor. The basis of calcium and interna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::f67386d12fec51f11fbaf7053633ab83
https://pubmed.ncbi.nlm.nih.gov/1744139

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Enhanced tumorigenesis of NR6 cells which express non-down-regulating epidermal growth factor receptors

Autor: H, Masui, A, Wells, C S, Lazar, M G, Rosenfeld, G N, Gill

Publikováno v: Cancer research. 51(22)

Sequences in the regulatory carboxyl terminus of the epidermal growth factor (EGF) receptor are required for ligand-induced internalization via a high-affinity saturable endocytic pathway and for receptor down-regulation. To investigate the role of d

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::d0c491bd2198e7870b50555be4284457
https://pubmed.ncbi.nlm.nih.gov/1933876

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Phosphorylation of the epidermal growth factor receptor at threonine 654 inhibits ligand-induced internalization and down-regulation

Autor: K A, Lund, C S, Lazar, W S, Chen, B J, Walsh, J B, Welsh, J J, Herbst, G M, Walton, M G, Rosenfeld, G N, Gill, H S, Wiley

Publikováno v: The Journal of biological chemistry. 265(33)

To assess the functional significance of phosphorylation of the epidermal growth factor (EGF) receptor at Thr654, we compared the effects of 12-O-tetradecanoyl-13-acetate (TPA) on ligand-induced internalization and down-regulation between wild-type a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::5ec818eb8c199ce2b5bb591a5493316c
https://pubmed.ncbi.nlm.nih.gov/2173710

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Akademický článek

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Akademický článek

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Alteration of epidermal growth factor receptor activity by mutation of its primary carboxyl-terminal site of tyrosine self-phosphorylation

Autor: W S Chen, Paul J. Bertics, G N Gill, C S Lazar, M G Rosenfeld, L Hubler

Publikováno v: Journal of Biological Chemistry. 263:3610-3617

The epidermal growth factor (EGF) receptor, which exhibits intrinsic protein tyrosine kinase activity, undergoes a rapid, intramolecular self-phosphorylation reaction following EGF activation. The primary sites of tyrosine self-phosphorylation in viv

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::6c345a19597046a601731d7735c5971f
https://doi.org/10.1016/s0021-9258(18)68968-9

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Relation of epidermal growth factor receptor concentration to growth of human epidermoid carcinoma A431 cells

Autor: John Mendelsohn, A Le, Gordon N. Gill, C S Lazar, T Kawamoto, Gordon Sato

Publikováno v: Journal of Biological Chemistry. 259:7761-7766

The relation between the concentration of epidermal growth factor (EGF) receptor/kinase and effects of EGF on cell proliferation has been studied using variant A431 cells and antagonist anti-EGF receptor monoclonal antibodies. Clonal A431 cell varian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::642da18733485a6d9b20eadf84d09025
https://doi.org/10.1016/s0021-9258(17)42858-4

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Akademický článek

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