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Akademický článek

Effectiveness of an inactivated Covid-19 vaccine with homologous and heterologous boosters against Omicron in Brazil

Autor: Otavio T. Ranzani, Matt D. T. Hitchings, Rosana Leite de Melo, Giovanny V. A. de França, Cássia de Fátima R. Fernandes, Margaret L. Lind, Mario Sergio Scaramuzzini Torres, Daniel Henrique Tsuha, Leticia C. S. David, Rodrigo F. C. Said, Maria Almiron, Roberto D. de Oliveira, Derek A. T. Cummings, Natalie E. Dean, Jason R. Andrews, Albert I. Ko, Julio Croda

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)

This study investigates the effectiveness of COVID-19 vaccine boosters following a primary series of CoronaVac vaccination. Using data from Brazil during the Omicron wave, the authors show that boosters provided protection against severe disease, wit

Externí odkaz: https://doaj.org/article/919ab014f1f4481c97bbee1f6cf98e16

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HLA-DR polymorphisms influence in vivo responses to staphylococcal toxic shock syndrome toxin-1 in a transgenic mouse model

Autor: A, Krogman, A, Tilahun, C S, David, V R, Chowdhary, M P, Alexander, G, Rajagopalan

Publikováno v: HLA. 89(1)

Toxic shock syndrome toxin-1 (TSST-1) is a potent superantigen produced by Staphylococcus aureus. In addition to menstrual and nonmenstrual toxic shock syndromes, TSST-1 is also implicated in the immunopathogenesis of pneumonia, infective endocarditi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::09a49dc767bfcd2c81659aecbb0f7715
https://pubmed.ncbi.nlm.nih.gov/27863161

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Critical residues on HLA-DRB1*0402 HV3 peptide for HLA-DQ8-restricted immunogenicity: implications for rheumatoid arthritis predisposition

Autor: E Zanelli, C J Krco, C S David

Publikováno v: The Journal of Immunology. 158:3545-3551

Recently, we have proposed that the combination of HLA-DQ and -DR alleles is responsible for the association of the HLA class II region with rheumatoid arthritis (RA). According to this model, some HLA-DQ alleles, namely DQ4, DQ7, DQ8, and DQ9, predi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0d072c86c4c0847793e35c03746149f1
https://doi.org/10.4049/jimmunol.158.7.3545

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HLA-DQ8 transgenic mice lacking endogenous class II molecules respond to house dust allergens: identification of antigenic epitopes

Autor: T Neeno, C J Krco, J Harders, J Baisch, S Cheng, C S David

Publikováno v: The Journal of Immunology. 156:3191-3195

We have introduced HLA-DQ8 (HLADQB*0302 and HLA-DQA*0301) genes into A beta 0 knockout mice. Transgenic animals were immunized with a whole body extract of Dermatophagoides pteronyssinus (Der p), one of the causative agents of house dust mite allergy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::5464e1dcd63844dd0cdd73a67cc27e88
https://doi.org/10.4049/jimmunol.156.9.3191

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Characterization of the antigenic structure of human type II collagen

Autor: C J Krco, J Pawelski, J Harders, D McCormick, M Griffiths, H S Luthra, C S David

Publikováno v: The Journal of Immunology. 156:2761-2768

A series of 101 peptides each 20 amino acids in length (10-residue overlap) spanning the helical portion of the mature alpha-chain of human type II collagen (CII) was synthesized. DBA/1 (H-2q) mice were immunized with individual peptides, and drainin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::652ef0507457a43b9c1807a68c233d9d
https://doi.org/10.4049/jimmunol.156.8.2761

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Primary hormonogenic sites as conserved autoepitopes on thyroglobulin in murine autoimmune thyroiditis. Secondary role of iodination

Autor: Y C Kong, D J McCormick, Q Wan, R W Motte, B E Fuller, A A Giraldo, C S David

Publikováno v: The Journal of Immunology. 155:5847-5854

We hypothesized earlier that conserved T cell epitopes and those unique to mouse thyroglobulin (MTg) contributed to its total thyroiditogenicity in murine autoimmune thyroiditis. Recent studies of synthetic peptides from human Tg (HTg) revealed no im

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8f0600caf4057be629f9b2aa255e48fc
https://doi.org/10.4049/jimmunol.155.12.5847

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Oral administration of an immunodominant human collagen peptide modulates collagen-induced arthritis

Autor: S D Khare, C J Krco, M M Griffiths, H S Luthra, C S David

Publikováno v: The Journal of Immunology. 155:3653-3659

Human type II collagen (HuCII) may be one of the autoantigens involved in human rheumatoid arthritis (RA). By using over-lapping peptides, we have previously described an immunodominant region (HuCII.250-270) on HuCII. In the present study, this 21-m

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::825673f26fdeb94895dcb47f1513e19f
https://doi.org/10.4049/jimmunol.155.7.3653

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