Zobrazeno 1 - 10
of 30
pro vyhledávání: '"C S, Aaron"'
Publikováno v:
Journal of Applied Toxicology. 19:133-140
In collecting inhalation toxicity data for the evaluation of the health hazard from occupational exposure to the aerosols of a drug or a chemical, the determination of the inhaled dose in relation to the animal response is most desirable. Intratrache
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::58071ff57bf8f17895104ff457e023ce
https://doi.org/10.1002/(sici)1099-1263(199903/04)19:2<133::aid-jat549>3.0.co
https://doi.org/10.1002/(sici)1099-1263(199903/04)19:2<133::aid-jat549>3.0.co
Publikováno v:
Journal of Applied Toxicology. 18:149-160
The effectiveness of three techniques to deliver a diazo dye suspension into the lungs of rats was compared. The intratracheal nebulization (ITN) technique delivered 10 microl of the suspension per 5-ml puff of air in 10 puffs as an aerosol. The intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7da4cf4f5645012696f482b4f09c8033
https://doi.org/10.1002/(sici)1099-1263(199803/04)18:2<149::aid-jat490>3.0.co
https://doi.org/10.1002/(sici)1099-1263(199803/04)18:2<149::aid-jat490>3.0.co
Autor:
G. E. Padbury, P. G. Larson, C. S. Aaron, L. S. Banitt, K. L. Linseman, J. K. Mayo, J. E. Chin, P. A. Yonkers, Heidi M. Scherch, E. D. Hall, Stephen A. Mizsak, K. L. Belonga, Gordon L. Bundy, J. M. Lin, F. F. Sun, J. M. Tustin, I. M. Richards, Donald E. Ayer, John R. Palmer
Publikováno v:
ChemInform. 27
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::53e41174a634527607b1c5c03a355d49
https://doi.org/10.1002/chin.199607175
https://doi.org/10.1002/chin.199607175
Publikováno v:
Environmental and molecular mutagenesis. 33(3)
We compared the lambda cII/cI transgenic mutation assay described by Jakubczak et al. [(1996): Proc Natl Acad Sci USA 93:9073-9078] to the previously established Big Blue assay. Genomic DNA isolated from liver, spleen, and lung tissue of control or e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::99a8f49fff6295f24c353dc89eb361e9
https://pubmed.ncbi.nlm.nih.gov/10334627
https://pubmed.ncbi.nlm.nih.gov/10334627
Publikováno v:
Environmental and molecular mutagenesis. 33(2)
We tested the ability of a series of known genotoxic agents to cause mutations at the hprt locus in peripheral blood T-lymphocytes of cynomolgus monkeys as measured by the ability to form clones in the presence of 6-thioguanine. Ethylmethane sulfonat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::211633d49cc77820baa7149946172c51
https://pubmed.ncbi.nlm.nih.gov/10217066
https://pubmed.ncbi.nlm.nih.gov/10217066
Publikováno v:
Environmental and molecular mutagenesis. 33(2)
Big Blue mice harbor a recoverable transgene in a lambda/LIZ shuttle vector. In the standard assay, in vivo mutations are measured in the bacterial lacI gene using a labor-intensive color plaque assay. Applying a simpler assay [Jakubczak et al. (1996
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::c6c7cdb6cf430527c2f4b5e70a2c59fc
https://pubmed.ncbi.nlm.nih.gov/10217067
https://pubmed.ncbi.nlm.nih.gov/10217067
Publikováno v:
Environmental and molecular mutagenesis. 33(1)
We have been studying in vivo mutagenesis at the hypoxanthine phosphoribosyl transferase (hprt) locus in cynomolgus monkey T-lymphocytes. This primate model allows us to study mutations and their kinetics under well-controlled conditions. Previously,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba42ac014d7bb36f12460752bc35af15
https://pubmed.ncbi.nlm.nih.gov/10037322
https://pubmed.ncbi.nlm.nih.gov/10037322
Publikováno v:
Environmental and molecular mutagenesis. 32(4)
We examined several experimental parameters of the lambda cI/cII transgenic mutation assay. In the assay, clear plaque lambda phage mutants are identified in a positive selection scheme following rescue of the lambda/LIZ shuttle vector from frozen ti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::679815f0edcf97a6738a0604729f4a70
https://pubmed.ncbi.nlm.nih.gov/9882006
https://pubmed.ncbi.nlm.nih.gov/9882006
Publikováno v:
Journal of applied toxicology : JAT. 18(2)
The effectiveness of three techniques to deliver a diazo dye suspension into the lungs of rats was compared. The intratracheal nebulization (ITN) technique delivered 10 microl of the suspension per 5-ml puff of air in 10 puffs as an aerosol. The intr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a87f979c15829cb30b2a359cf09c218a
https://pubmed.ncbi.nlm.nih.gov/9570698
https://pubmed.ncbi.nlm.nih.gov/9570698
Autor:
D M, Zimmer, C S, Aaron
Publikováno v:
Environmental and molecular mutagenesis. 29(2)
We have monitored mutant frequency at the HPRT locus in peripheral blood lymphocytes of cynomolgus monkeys using a clonal assay in which mutants are selected by resistance to 6-thioguanine. Among untreated animals, the mean spontaneous mutant frequen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::75970e2505531253091a2f7f813c0a2b
https://pubmed.ncbi.nlm.nih.gov/9118963
https://pubmed.ncbi.nlm.nih.gov/9118963