Výsledky vyhledávání - "C Ryland Ill"

Multiple cancer types rapidly escape from multiple MAPK inhibitors to generate mutagenesis-prone subpopulations

Autor: Timothy E. Hoffman, Chen Yang, Varuna Nangia, C. Ryland Ill, Sabrina L. Spencer

Publikováno v: bioRxiv

Many cancers harbor pro-proliferative mutations of the mitogen-activated protein kinase (MAPK) pathway and many targeted inhibitors now exist for clinical use, but drug resistance remains a major issue. We recently showed that BRAF-driven melanoma ce

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ab42bc85da173967f1f2fb71a4ff2c6
https://doi.org/10.1101/2023.03.17.533211

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Abstract 5992: Cells rapidly adapt to CDK2 inhibitors via plasticity of the CDK2/4/6-Rb-E2F axis

Autor: Mansi Arora, Justin Moser, Timothy E. Hoffman, Lotte P. Watts, Mingwei Min, Monica Musteanu, Yao Rong, Jordan Schneider, C Ryland Ill, Varuna Nangia, Manuel Sanclemente, John Lapek, Lisa Nguyen, Sherry Niessen, Stephen Dann, Todd van Arsdale, Mariano Barbacid, Nichol Miller, Sabrina L. Spencer

Publikováno v: Cancer Research. 83:5992-5992

CDK2 is a core cell-cycle enzyme that phosphorylates a variety of substrates to drive progression through the cell cycle. CDK2 is hyperactivated in multiple cancers and is therefore an attractive therapeutic target. Here, application of a novel small

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1a6262ebc0d17cc970398e20e0286827
https://doi.org/10.1158/1538-7445.am2023-5992

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