Zobrazeno 1 - 10
of 398
pro vyhledávání: '"C Russell, Middaugh"'
Autor:
Gang Hu, David J. Varisco, Sayan Das, C. Russell Middaugh, Francesca Gardner, Robert K. Ernst, Wendy L. Picking, William D. Picking
Publikováno v:
Heliyon, Vol 9, Iss 7, Pp e18119- (2023)
Toll-like receptor (TLR) agonists are recognized as potential immune-enhancing adjuvants and are included in several licensed vaccines. Monophosphoryl lipid A (MPL®, GlaxoSmithKline) is one such TLR4 agonist that has been approved for use in human v
Externí odkaz:
https://doaj.org/article/af462990fe1f49968dbe51a4fba38255
Autor:
Nicholas R, Larson, Yangjie, Wei, Thayana Araújo, Cruz, Reza, Esfandiary, Cavan K, Kalonia, M Laird, Forrest, C Russell, Middaugh
Publikováno v:
Journal of Pharmaceutical Sciences. 112:680-690
Liquid-liquid phase separation is a phenomenon within biology whereby proteins can separate into dense and more dilute phases with distinct properties. Three antibodies that undergo liquid-liquid phase separation were characterized in the protein-ric
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eb964b48d028310f96720b71a6f27ac
https://doi.org/10.1016/j.xphs.2022.10.017
https://doi.org/10.1016/j.xphs.2022.10.017
Autor:
Jimmy Y. Song, J. Daniel Griffin, Nicholas R. Larson, Matthew A. Christopher, C. Russell Middaugh, Cory J. Berkland
Publikováno v:
Frontiers in Immunology, Vol 11 (2021)
A synthetic peptide, K-PLP, consisting of 11-unit poly-lysine (K11) linked via polyethylene glycol (PEG) to proteolipid protein epitope (PLP) was synthesized, characterized, and evaluated for efficacy in ameliorating experimental autoimmune encephalo
Externí odkaz:
https://doaj.org/article/c75d40fc11f8442c9fe8c94db263c63b
Autor:
Alex A. Meier, Hee-Jung Moon, Ronald Toth, Ewa Folta-Stogniew, Krzysztof Kuczera, C. Russell Middaugh, Minae Mure
Publikováno v:
Biomolecules, Vol 11, Iss 12, p 1846 (2021)
Lysyl oxidase-like 2 (LOXL2) has emerged as a promising therapeutic target against metastatic/invasive tumors and organ and tissue fibrosis. LOXL2 catalyzes the oxidative deamination of lysine and hydroxylysine residues in extracellular matrix (ECM)
Externí odkaz:
https://doaj.org/article/8ff12db5c7694f44b9580dd423ef49a8
Publikováno v:
Biomolecules, Vol 11, Iss 9, p 1351 (2021)
Fast kinetic experiments with dramatically improved time resolution have contributed significantly to understanding the fundamental processes in protein folding pathways involving the formation of a-helices and b-hairpin, contact formation, and overa
Externí odkaz:
https://doaj.org/article/34871284919c4217ae02b01cb7ce2dad
Autor:
C. Russell Middaugh, Yangjie Wei, M. Laird Forrest, Nicholas R. Larson, Gang Hu, Anthony Tuesesca
Publikováno v:
Journal of Pharmaceutical Sciences. 111:690-698
Lipid nanoparticles (LNPs) containing mRNA can deliver genetic material to cells for use as vaccines or protein replacement therapies. We characterized the effect of solution pH on cationic LNPs containing green fluorescent protein (EGFP) mRNA and th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2803a7bbb75102e94fbac3a63b096768
https://doi.org/10.1016/j.xphs.2021.11.004
https://doi.org/10.1016/j.xphs.2021.11.004
Publikováno v:
The Journal of Physical Chemistry B. 125:10972-10984
Picosecond time-resolved fluorescence anisotropy was used to measure the effect of denaturants and osmolytes on the reorientation dynamics of the simplest dipeptide. The solvent denaturants guanidinium hydrochloride (gdm), urea, and the osmolyte prol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8d0afc724e9495a3e18f691db43418f2
https://doi.org/10.1021/acs.jpcb.1c06838
https://doi.org/10.1021/acs.jpcb.1c06838
Autor:
Nicholas R. Larson, Sureshkumar Choudhary, C. Russell Middaugh, Indira Prajapati, Christian Schöneich, Suzanne Hudak, Cavan Kalonia, Reza Esfandiary
Publikováno v:
Molecular Pharmaceutics. 18:3223-3234
We investigated the discoloration of a highly concentrated monoclonal antibody (mAbZ) in sodium acetate (NaAc) and histidine/lysine (His/Lys) buffer after exposure to visible light. The color change of the mAbZ formulation was significantly more inte
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1ef3ae15743144d89958724a48ff2fa3
https://doi.org/10.1021/acs.molpharmaceut.1c00043
https://doi.org/10.1021/acs.molpharmaceut.1c00043
Autor:
Siva Krishna Angalakurthi, David J. Vance, Yinghui Rong, Chi My Thi Nguyen, Michael J. Rudolph, David Volkin, C. Russell Middaugh, David D. Weis, Nicholas J. Mantis
Publikováno v:
Antibodies, Vol 7, Iss 4, p 45 (2018)
In this report, we used hydrogen exchange-mass spectrometry (HX-MS) to identify the epitopes recognized by 21 single-domain camelid antibodies (VHHs) directed against the ribosome-inactivating subunit (RTA) of ricin toxin, a biothreat agent of concer
Externí odkaz:
https://doaj.org/article/08b529d18940415d831f6223da371ea8
Autor:
C. Russell Middaugh, Tim J. Kamerzell
Publikováno v:
Journal of Pharmaceutical Sciences. 110:665-681
The rapid growth in technological advances and quantity of scientific data over the past decade has led to several challenges including data storage and analysis. Accurate models of complex datasets were previously difficult to develop and interpret.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::49e0336c5cae218be84e153974619af7
https://doi.org/10.1016/j.xphs.2020.11.034
https://doi.org/10.1016/j.xphs.2020.11.034