Ret inhibition decreases growth and metastatic potential of estrogen receptor positive breast cancer cells

Autor: Albana Gattelli, Ivan Nalvarte, Anne Boulay, Tim C. Roloff, Martin Schreiber, Neil Carragher, Kenneth K. Macleod, Michaela Schlederer, Susanne Lienhard, Lukas Kenner, Maria I. Torres‐Arzayus, Nancy E. Hynes

Publikováno v: EMBO Molecular Medicine, Vol 5, Iss 9, Pp 1335-1350 (2013)

Abstract We show that elevated levels of Ret receptor are found in different sub‐types of human breast cancers and that high Ret correlates with decreased metastasis‐free survival. The role of Ret in ER+ breast cancer models was explored combinin

Externí odkaz: https://doaj.org/article/47347e25c8bd4575a7716c866b631f36

Genomic prevalence of heterochromatic H3K9me2 and transcription do not discriminate pluripotent from terminally differentiated cells.

Autor: Florian Lienert, Fabio Mohn, Vijay K Tiwari, Tuncay Baubec, Tim C Roloff, Dimos Gaidatzis, Michael B Stadler, Dirk Schübeler

Publikováno v: PLoS Genetics, Vol 7, Iss 6, p e1002090 (2011)

Cellular differentiation entails reprogramming of the transcriptome from a pluripotent to a unipotent fate. This process was suggested to coincide with a global increase of repressive heterochromatin, which results in a reduction of transcriptional p

Externí odkaz: https://doaj.org/article/edf8fc02c7a84692b1783486f21c2db6

Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion

Autor: Nancy E. Hynes, Stephan Duss, Dominique S. Meyer, Mohamed Bentires-Alj, Tim-C Roloff, Gwen MacDonald, Nicola Aceto

Publikováno v: Aceto, Nicola; Duss, Stephan; MacDonald, Gwen; Meyer, Dominique S; Roloff, Tim-C; Hynes, Nancy E; et al.(2012). Co-expression of HER2 and HER3 receptor tyrosine kinases enhances invasion of breast cells via stimulation of interleukin-8 autocrine secretion. Breast Cancer Research, 14(5), R131. doi: http://dx.doi.org/10.1186/bcr3329. Retrieved from: http://www.escholarship.org/uc/item/6106p69m
Breast Cancer Research : BCR

Introduction The tyrosine kinase receptors HER2 and HER3 play an important role in breast cancer. The HER2/HER3 heterodimer is a critical oncogenic unit associated with reduced relapse-free and decreased overall survival. While signaling cascades dow

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf4a57e0f3c8533100f036191ad45344
http://www.escholarship.org/uc/item/6106p69m

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