Zobrazeno 1 - 10
of 732
pro vyhledávání: '"C Riddle"'
Autor:
Matthew D. Howe, Karysa J. Britton, Hannah E. Joyce, William Menard, Sheina Emrani, Zachary J. Kunicki, Melanie A. Faust, Brittany C. Dawson, Meghan C. Riddle, Edward D. Huey, Shorena Janelidze, Oskar Hansson, Stephen P. Salloway
Publikováno v:
Alzheimer’s Research & Therapy, Vol 16, Iss 1, Pp 1-14 (2024)
Abstract Background With the approval of disease-modifying treatments (DMTs) for early Alzheimer’s disease (AD), there is an increased need for efficient and non-invasive detection methods for cerebral amyloid-β (Aβ) pathology. Current methods, i
Externí odkaz:
https://doaj.org/article/45714cef87b14c3381fb405472bc50ab
Autor:
Joseph Choi, Danielle M. Smith, Ye Jin Lee, Danfeng Cai, Mohammad J. Hossain, Tamara J. O’Connor, Pragney Deme, Norman J. Haughey, Susanna Scafidi, Ryan C. Riddle, Michael J. Wolfgang
Publikováno v:
iScience, Vol 27, Iss 9, Pp 110642- (2024)
Summary: Etomoxir has been used for decades as a popular small molecule inhibitor of carnitine palmitoyltransferase I, Cpt1, to block mitochondrial fatty acid β-oxidation. To test the specificity of etomoxir, we generated click chemistry–enabled r
Externí odkaz:
https://doaj.org/article/937993dcfc3540bfb41e12efc0dd8eca
Autor:
Christine W Gao, WanYing Lin, Ryan C Riddle, Sheetal Chopra, Jiyoung Kim, Leandros Boukas, Kasper D Hansen, Hans T Björnsson, Jill A Fahrner
Publikováno v:
PLoS Genetics, Vol 20, Iss 6, p e1011310 (2024)
Growth deficiency is a characteristic feature of both Kabuki syndrome 1 (KS1) and Kabuki syndrome 2 (KS2), Mendelian disorders of the epigenetic machinery with similar phenotypes but distinct genetic etiologies. We previously described skeletal growt
Externí odkaz:
https://doaj.org/article/4bc73b4b5abe410a8220e06884a74d73
Autor:
Stephanie Doering, Austin McCullough, Brian A. Gordon, Charles D. Chen, Nicole McKay, Diana Hobbs, Sarah Keefe, Shaney Flores, Jalen Scott, Hunter Smith, Stephen Jarman, Kelley Jackson, Russ C. Hornbeck, Beau M. Ances, Chengjie Xiong, Andrew J. Aschenbrenner, Jason Hassenstab, Carlos Cruchaga, Alisha Daniels, Randall J. Bateman, John C. Morris, Tammie L.S. Benzinger, James M. Noble, Gregory S. Day, Neill R. Graff-Radford, Jonathan Voglein, Johannes Levin, Ricardo F. Allegri, Patricio Chrem Mendez, Ezequiel Surace, Sarah B. Berman, Snezana Ikonomovic, Neelesh K. Nadkarni, Francisco Lopera, Laura Ramirez, David Aguillon, Yudy Leon, Claudia Ramos, Diana Alzate, Ana Baena, Natalia Londono, Sonia Moreno, Mathias Jucker, Christoph Laske, Elke Kuder-Buletta, Susanne Graber-Sultan, Oliver Preische, Anna Hofmann, Takeshi Ikeuchi, Kensaku Kasuga, Yoshiki Niimi, Kenji Ishii, Michio Senda, Raquel Sanchez-Valle, Pedro Rosa-Neto, Nick C. Fox, Dave Cash, Jae-Hong Lee, Jee Hoon Roh, Stephen Salloway, Meghan C. Riddle, William Menard, Courtney Bodge, Mustafa Surti, Leonel Tadao Takada, Martin Farlow, Jasmeer P. Chhatwal, V.J. Sanchez-Gonzalez, Maribel Orozco-Barajas, Alison M. Goate, Alan E. Renton, Bianca T. Esposito, Celeste M. Karch, Jacob Marsh, Victoria Fernanadez, Anne M. Fagan, Gina Jerome, Elizabeth Herries, Jorge Llibre-Guerra, Allan I. Levey, Erik C.B. Johnson, Nicholas T. Seyfried, Peter R. Schofield, William S. Brooks, Jacob A. Bechara, Randall Bateman, Eric McDade, Richard J. Perrin, Erin E. Franklin, Tammie Benzinger, Allison Chen, Charles Chen, Nelly Friedrichsen, Brian Gordon, Nancy Hantler, Russ Hornbeck, Steve Jarman, Deborah Koudelis, Parinaz Massoumzadeh, Joyce Nicklaus, Christine Pulizos, Qing Wang, Sheetal Mishall, Edita Sabaredzovic, Emily Deng, Madison Candela, Peter Wang, Xiong Xu, Yan Li, Emily Gremminger, Yinjiao Ma, Ryan Bui, Ruijin Lu, Ralph Martins, Ana Luisa Sosa Ortiz, Laura Courtney, Hiroshi Mori, Charlene Supnet-Bell, Jinbin Xu, John Ringman, Nicolas Barthelemy, John Morris, Jennifer Smith
Publikováno v:
EBioMedicine, Vol 103, Iss , Pp 105080- (2024)
Summary: Background: Neuroimaging studies often quantify tau burden in standardized brain regions to assess Alzheimer disease (AD) progression. However, this method ignores another key biological process in which tau spreads to additional brain regio
Externí odkaz:
https://doaj.org/article/0b7b8db8958a47c9b99946f7b5107ddb
Publikováno v:
eLife, Vol 12 (2024)
Genome-wide association studies (GWAS) have identified a large number of candidate genes believed to affect longitudinal bone growth and bone mass. One of these candidate genes, TMEM263, encodes a poorly characterized plasma membrane protein. Single
Externí odkaz:
https://doaj.org/article/79f38225ad9b44c9aba3a5a68c278bad
Autor:
Megan C. Riddle, Joshua D. Safer
Publikováno v:
Journal of Eating Disorders, Vol 10, Iss 1, Pp 1-10 (2022)
Plain English summary Transgender and gender diverse (TGD) people are at increased risk for developing eating disorders, but very little is known about their unique medical needs while in eating disorder treatment. TGD refers to individuals whose sex
Externí odkaz:
https://doaj.org/article/2fb1b6e2934d451091cd30bf56ab554b
Autor:
Soohyun P. Kim, Avery H. Seward, Jean Garcia-Diaz, Nathalie Alekos, Nicole R. Gould, Susan Aja, Joseph P. Stains, Michael J. Wolfgang, Ryan C. Riddle
Publikováno v:
iScience, Vol 26, Iss 7, Pp 106999- (2023)
Summary: The nuclear receptor peroxisome proliferator activated receptor-γ (PPARγ) is a key contributor to metabolic function via its adipogenic and insulin-sensitizing functions, but it has negative effects on skeletal homeostasis. Here, we questi
Externí odkaz:
https://doaj.org/article/8130372e4d334e6aac79e1a1c9407456
Publikováno v:
Biomarkers in Neuropsychiatry, Vol 8, Iss , Pp 100063- (2023)
Alzheimer’s disease (AD) is an age-related neurodegenerative disease and the leading cause of dementia worldwide. AD is associated with several neuropathologic changes including the progressive accumulation of extracellular amyloid-β (Aβ) plaques
Externí odkaz:
https://doaj.org/article/07b60b991a394dc286409f6d3f51ae39
Publikováno v:
Frontiers in Physiology, Vol 14 (2023)
Externí odkaz:
https://doaj.org/article/42268edd2e4946a0957157d955f66356
Autor:
John M. Schoelz, Nicole C. Riddle
Publikováno v:
Epigenetics & Chromatin, Vol 15, Iss 1, Pp 1-15 (2022)
Abstract In eukaryotes, DNA is packaged into chromatin, which presents significant barriers to transcription. Non-histone chromatin proteins such as the Heterochromatin Protein 1 (HP1) proteins are critical regulators of transcription, contributing t
Externí odkaz:
https://doaj.org/article/005810cfa63a4198bcce791918d6db3a