Live attenuated Francisella novicida vaccine protects against Francisella tularensis pulmonary challenge in rats and non-human primates.

Autor: Ping Chu, Aimee L Cunningham, Jieh-Juen Yu, Jesse Q Nguyen, Jeffrey R Barker, C Rick Lyons, Julie Wilder, Michelle Valderas, Robert L Sherwood, Bernard P Arulanandam, Karl E Klose

Publikováno v: PLoS Pathogens, Vol 10, Iss 10, p e1004439 (2014)

Francisella tularensis causes the disease tularemia. Human pulmonary exposure to the most virulent form, F. tularensis subsp. tularensis (Ftt), leads to high morbidity and mortality, resulting in this bacterium being classified as a potential biothre

Externí odkaz: https://doaj.org/article/1ebc0856ec494ab0b302746fca14d45d

The Fischer 344 rat reflects human susceptibility to francisella pulmonary challenge and provides a new platform for virulence and protection studies.

Autor: Heather J Ray, Ping Chu, Terry H Wu, C Rick Lyons, Ashlesh K Murthy, M Neal Guentzel, Karl E Klose, Bernard P Arulanandam

Publikováno v: PLoS ONE, Vol 5, Iss 4, p e9952 (2010)

The pathogenesis of Francisella tularensis, the causative agent of tularemia, has been primarily characterized in mice. However, the high degree of sensitivity of mice to bacterial challenge, especially with the human virulent strains of F. tularensi

Externí odkaz: https://doaj.org/article/e8e3aa69be004e0fa4caa812a79ed972

Bacillus anthracis Overcomes an Amino Acid Auxotrophy by Cleaving Host Serum Proteins

Autor: Anthony William Maresso, Theresa M. Koehler, Kathryn J. Pflughoeft, Michelle C. Swick, C. Rick Lyons, Austen Terwilliger, Andrei P. Pomerantsev

Publikováno v: Journal of Bacteriology. 197:2400-2411

Bacteria sustain an infection by acquiring nutrients from the host to support replication. The host sequesters these nutrients as a growth-restricting strategy, a concept termed “nutritional immunity.” Historically, the study of nutritional immun

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5421b68a65683b9d1d74aebbfc116166
https://doi.org/10.1128/jb.00073-15

Identification of circulating bacterial antigens by in vivo microbial antigen discovery

Autor: D. Huw Davies, Farida Dwi Handayani, Philip L. Felgner, Thomas R. Kozel, C. Rick Lyons, Richard A. Bowen, Terry H. Wu, David P. AuCoin, Dana E. Nuti, Paul J. Brett, Mary N. Burtnick, Sharon J. Peacock, Reva B. Crump, Narisara Chantratita

Publikováno v: Nuti, Dana E; Crump, Reva B; Handayani, Farida Dwi; Chantratita, Narisara; Peacock, Sharon J; Bowen, Richard; et al.(2011). Identification of Circulating Bacterial Antigens by In Vivo Microbial Antigen Discovery. mBio, 2(4), e00136-11-e00136-11. doi: 10.1128/mBio.00136-11. UC Irvine: Retrieved from: http://www.escholarship.org/uc/item/4f65w413
mBio
mBio, Vol 2, Iss 4 (2011)

Detection of microbial antigens in clinical samples can lead to rapid diagnosis of an infection and administration of appropriate therapeutics. A major barrier in diagnostics development is determining which of the potentially hundreds or thousands o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::859d16f6f14f42000d9e06be742486e0
https://ora.ox.ac.uk/objects/uuid:b4f8ee38-5097-4b57-a180-8497278421b6

Antibodies Contribute to Effective Vaccination against Respiratory Infection by Type A Francisella tularensis Strains

Autor: C. Rick Lyons, Julie A. Hutt, Terry H. Wu, Gopi Mara-Koosham

Publikováno v: Infection and Immunity. 79:1770-1778

Pneumonic tularemia is a life-threatening disease caused by inhalation of the highly infectious intracellular bacterium Francisella tularensis . The most serious form of the disease associated with the type A strains can be prevented in experimental

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fcdfdb0535dd064a25b38c2ddd7a6874
https://doi.org/10.1128/iai.00605-10