Zobrazeno 1 - 10
of 145
pro vyhledávání: '"C Richter, King"'
Autor:
Barnabas G. Williams, Lloyd D. W. King, David Pulido, Doris Quinkert, Amelia M. Lias, Sarah E. Silk, Robert J. Ragotte, Hannah Davies, Jordan R. Barrett, Kirsty McHugh, Cassandra A. Rigby, Daniel G. W. Alanine, Lea Barfod, Michael W. Shea, Li An Cowley, Rebecca A. Dabbs, David J. Pattinson, Alexander D. Douglas, Oliver R. Lyth, Joseph J. Illingworth, Jing Jin, Cecilia Carnrot, Vinayaka Kotraiah, Jayne M. Christen, Amy R. Noe, Randall S. MacGill, C. Richter King, Ashley J. Birkett, Lorraine A. Soisson, Katherine Skinner, Kazutoyo Miura, Carole A. Long, Matthew K. Higgins, Simon J. Draper
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Reticulocyte-binding protein homologue 5 (RH5), a leading blood-stage Plasmodium falciparum malaria vaccine target, interacts with cysteine-rich protective antigen (CyRPA) and RH5-interacting protein (RIPR) to form an essential heterotrimeri
Externí odkaz:
https://doaj.org/article/c0357f954cd04ff984155d03439a386e
Autor:
Emily Locke, Yevel Flores-Garcia, Bryan T. Mayer, Randall S. MacGill, Bhavesh Borate, Berenice Salgado-Jimenez, Monica W. Gerber, Shamika Mathis-Torres, Sarah Shapiro, C. Richter King, Fidel Zavala
Publikováno v:
npj Vaccines, Vol 9, Iss 1, Pp 1-14 (2024)
Abstract New strategies are needed to reduce the incidence of malaria, and promising approaches include vaccines targeting the circumsporozoite protein (CSP). To improve upon the malaria vaccine, RTS,S/AS01, it is essential to standardize preclinical
Externí odkaz:
https://doaj.org/article/cb9a8e98e3904d03ab567757f16ec3bd
Autor:
Maartje R. Inklaar, Roos M. de Jong, Ezra T. Bekkering, Hikaru Nagaoka, Felix L. Fennemann, Karina Teelen, Marga van de Vegte-Bolmer, Geert-Jan van Gemert, Rianne Stoter, C. Richter King, Nicholas I. Proellochs, Teun Bousema, Eizo Takashima, Takafumi Tsuboi, Matthijs M. Jore
Publikováno v:
npj Vaccines, Vol 8, Iss 1, Pp 1-8 (2023)
Abstract Malaria transmission-blocking vaccines (TBVs) aim to induce antibodies that block Plasmodium parasite development in the mosquito midgut, thus preventing mosquitoes from becoming infectious. While the Pro-domain and first of fourteen 6-Cyste
Externí odkaz:
https://doaj.org/article/873417ee2eae4bd1826b51bf24506c7a
Autor:
Gregory M. Martin, Jonathan L. Torres, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Grace Gibson, Re’em Moskovitz, Nathan Beutler, Diana D. Jung, Jeffrey Copps, Wen-Hsin Lee, Gonzalo Gonzalez-Paez, Daniel Emerling, Randall S. MacGill, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson, Andrew B. Ward
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-16 (2023)
Abstract The generation of high-quality antibody responses to Plasmodium falciparum (Pf) circumsporozoite protein (PfCSP), the primary surface antigen of Pf sporozoites, is paramount to the development of an effective malaria vaccine. Here we present
Externí odkaz:
https://doaj.org/article/9852dbd3db8d470488cfc46ea2bb7db5
Autor:
Wei-Chiao Huang, Moustafa T. Mabrouk, Luwen Zhou, Minami Baba, Mayumi Tachibana, Motomi Torii, Eizo Takashima, Emily Locke, Jordan Plieskatt, C. Richter King, Camila H. Coelho, Patrick E. Duffy, Carole Long, Takafumi Tsuboi, Kazutoyo Miura, Yimin Wu, Tomoko Ishino, Jonathan F. Lovell
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Co-display of two P. falciparum malaria vaccine antigens (Pfs230D1+ and CSP) on the surface of immunogenic liposomes results in functional immune responses upon immunization of mice and rabbits. Combining both antigens produces immune responses that
Externí odkaz:
https://doaj.org/article/f8e6b970eebc47eab359d0eb8d1b356e
Autor:
Kazutoyo Miura, Eizo Takashima, Thao P. Pham, Bingbing Deng, Luwen Zhou, Wei-Chiao Huang, Ababacar Diouf, Yonas T. Gebremicale, Mayumi Tachibana, Tomoko Ishino, C. Richter King, Jonathan F. Lovell, Carole A. Long, Takafumi Tsuboi
Publikováno v:
npj Vaccines, Vol 7, Iss 1, Pp 1-10 (2022)
Abstract Pfs230 is a leading malaria transmission blocking vaccine (TBV) candidate. Comprising 3135 amino acids (aa), the large size of Pfs230 necessitates the use of sub-fragments as vaccine immunogens. Therefore, determination of which regions indu
Externí odkaz:
https://doaj.org/article/443d66dfac1e4aaf99ee198dffee8caa
Autor:
Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Gonzalo Gonzalez-Paez, Zhen Han, Katherine L. Williams, Wayne Volkmuth, Daniel Emerling, Emily Locke, C. Richter King, Fidel Zavala, Ian A. Wilson
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
The most advanced P. falciparum circumsporozoite protein (PfCSP)-based malaria vaccine confers partial protection. Here, Pholcharee et al. present crystal structures, binding affinities/kinetics, and in vivo protection of 8 anti-NANP antibodies to un
Externí odkaz:
https://doaj.org/article/f69e762087b34c9ba0a1c8a3d1c005e9
Autor:
Rama Raghunandan, Bryan T. Mayer, Yevel Flores-Garcia, Monica W. Gerber, Raphael Gottardo, Hugo Jhun, Sonia M. Herrera, Daniel W. Perez-Ramos, Emily Locke, C. Richter King, Fidel Zavala
Publikováno v:
Malaria Journal, Vol 19, Iss 1, Pp 1-15 (2020)
Abstract Background New strategies are needed to reduce the incidence of malaria, and promising approaches include the development of vaccines and monoclonal antibodies (mAbs) that target the circumsporozoite protein (CSP). To select the best candida
Externí odkaz:
https://doaj.org/article/4b5eb85f1d8e48149087791ff171d018
Autor:
Nathan Beutler, Tossapol Pholcharee, David Oyen, Yevel Flores-Garcia, Randall S MacGill, Elijah Garcia, Jaeson Calla, Mara Parren, Linlin Yang, Wayne Volkmuth, Emily Locke, Jason A Regules, Sheetij Dutta, Daniel Emerling, Angela M Early, Daniel E Neafsey, Elizabeth A Winzeler, C Richter King, Fidel Zavala, Dennis R Burton, Ian A Wilson, Thomas F Rogers
Publikováno v:
PLoS Pathogens, Vol 18, Iss 3, p e1010409 (2022)
Potent and durable vaccine responses will be required for control of malaria caused by Plasmodium falciparum (Pf). RTS,S/AS01 is the first, and to date, the only vaccine that has demonstrated significant reduction of clinical and severe malaria in en
Externí odkaz:
https://doaj.org/article/466c773f347b462fb6e06036904736dc
Autor:
Yevel Flores-Garcia, Sonia M. Herrera, Hugo Jhun, Daniel W. Pérez-Ramos, C. Richter King, Emily Locke, Ramadevi Raghunandan, Fidel Zavala
Publikováno v:
Malaria Journal, Vol 18, Iss 1, Pp 1-9 (2019)
Abstract Background The circumsporozoite protein (CSP) of Plasmodium is a key surface antigen that induces antibodies and T-cells, conferring immune protection in animal models and humans. However, much of the work on CSP and immunity has been develo
Externí odkaz:
https://doaj.org/article/e0aba6ced59141d4b83fc7305e88af82