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Publikováno v:
Journal of Pharmacy and Pharmacology. 52:1129-1135
The dopamine receptor agonist ropinirole (SKF-101468) is used to treat Parkinson's disease. Ropinirole is metabolized by two routes to a series of different metabolites although the predominant pathway is species-dependent. It is unknown whether any
Publikováno v:
Neuropharmacology. 36:787-792
It has been suggested that a sub-population of dopamine D3 receptors is located pre-synaptically and these serve as autoreceptors in dopamine projection areas such as the nucleus accumbens/ventral striatum. To study further the physiological role and
Publikováno v:
Neuropharmacology. 34:449-455
High doses of dopamine D2 receptor agonists produce hyperactivity in rodents whereas low doses suppress activity. In this study, low doses of a range of dopamine agonists were examined for their effects on locomotor activity in rats. All agonists cau
Publikováno v:
British Journal of Pharmacology. 126:572-574
Atypical neuroleptics produce fewer extrapyramidal side-effects (EPS) than typical neuroleptics. The pharmacological profile of atypical neuroleptics is that they have equivalent or higher antagonist affinity for 5-HT2 than for dopamine D2 receptors.
Publikováno v:
Ciba Foundation Symposium 107-Functions of the Basal Ganglia
Neurons containing gamma-aminobutyric acid (GABA) are important outflow pathways from the striatum to the pallidal complex and substantia nigra. From these areas GABA-containing neurons pass to the thalamus and to various areas of the brainstem. Mani
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4cb9fe7093ff0b2b186e6c4a2597500a
https://doi.org/10.1002/9780470720882.ch9
https://doi.org/10.1002/9780470720882.ch9
Publikováno v:
Psychopharmacology. 102:521-528
The nicotinic agonists N-(3-pyridylmethyl)pyrrolidine (PMP) and isoarecolone have been compared with (-)-nicotine in three behavioural procedures and as inhibitors of [3H]-(-)-nicotine binding. Locomotor activity was recorded as movements between bea
Publikováno v:
Neuropharmacology. 29:619-624
Previous work has suggested that cytisine and lobeline are of low potency in producing nicotine-like behavioural effects, despite having some nicotine-like peripheral effects and potently inhibiting the binding of tritiated nicotine to the brain of t
Autor:
C. Reavill, Ian P. Stolerman
Publikováno v:
British Journal of Pharmacology. 99:273-278
1. Nicotine (0.13 and 0.4 mg kg-1, s.c.) increased the ambulatory component of locomotor activity in rats previously exposed to the drug. Nicotine did not increase repeated movements reliably. 2. An infusion of either nicotine (8 micrograms) or the p
Autor:
C, Reavill, D C, Rogers
Publikováno v:
Current opinion in investigational drugs (London, England : 2000). 2(1)