Zobrazeno 1 - 10
of 25
pro vyhledávání: '"C R Newton"'
Publikováno v:
Diagnostic Molecular Pathology. 8:205-210
The mother and second child from a family, already with one PI ZZ child, were typed PI MZ by isoelectric focusing and unexpectedly as PI ZZ using a commercial alpha-1-antitrypsin genotyping kit. Both methods typed the father and first child as PI MZ
Autor:
C. R. Newton, S. L. Weston, S. J. Kelly, N. H. Robertson, P. Elsmore, S. R. Pearce, N. J. Duxbury, M. B. T. Webb, S. Little
Publikováno v:
European Respiratory Journal. 12:477-482
The results obtained using deoxyribonucleic acid (DNA) amplification-based tests must be accurate and reproducible. One such test that simultaneously detects any of 12 of the most common mutations of the cystic fibrosis transmembrane conductance regu
Autor:
P. White, J. C. Fox, C. R. Newton, J. M. A. Northover, Ian C. Talbot, D. Snary, J. Smith-Ravin, T. L. Mccarthy, N. R. Charlesworth, K. Callaghan, S. Little, G. Ellison, J. England, J. Hehir
Publikováno v:
British Journal of Cancer
A total of 301 colorectal carcinoma (CRC) archival samples were analysed using the amplification-refractory mutation system (ARMS). Each sample was examined to determine the mutation status of codons 12 and 13 of the K-ras oncogene. The results from
Autor:
N Peshu, C R Newton, Kevin Marsh, C Waruiru, Brian Kendall, S A Murphy, Fenella J. Kirkham, A Sowunmi, I Mwangi
Publikováno v:
Archives of Disease in Childhood. 70:281-287
Computed tomography was performed on 14 unconscious Kenyan children recovering from cerebral malaria (seven of whom had another scan 12-120 days later) to elucidate the cause of intracranial hypertension and neurological sequelae. Brain swelling, def
Autor:
R G, Wagner, C R, Newton
Publikováno v:
Parasite immunology. 31(11)
Both helminthiases and epilepsy occur globally, and are particularly prevalent in developing regions of the world. Studies have suggested an association between epilepsy and helminth infection, but a causal relationship is not established in many hel
Publikováno v:
Clinical Chemistry. 37:1983-1987
We report a method for the diagnosis of familial defective apolipoprotein (apo) B-100, using the Amplification Refractory Mutation System (ARMS) and either whole blood or extracted DNA in the polymerase chain reaction. Normal and mutant alleles are i
Autor:
Oscar Kai, Kathryn Maitland, Mike English, David J. Roberts, Thomas N. Williams, C R Newton, Norbert Peshu, Climent Casals-Pascual, Brett Lowe
Publikováno v:
Malaria Journal
Malaria Journal, Vol 5, Iss 1, p 101 (2006)
Malaria Journal, Vol 5, Iss 1, p 101 (2006)
BackgroundHyperlactataemia is often associated with a poor outcome in severe malaria in African children. To unravel the complex pathophysiology of this condition the relationship between plasma lactate levels, parasite density, pro- and anti-inflamm
Oxidative stress and erythrocyte damage in Kenyan children with severe Plasmodium falciparum malaria
Publikováno v:
British journal of haematology. 113(2)
Anaemia causes significant morbidity in children with Plasmodium falciparum malaria, but the mechanism(s) are unclear. During malarial infection, increased reactive oxygen species (ROS) are generated that may contribute to erythrocyte damage and anae
Publikováno v:
Journal of neurology, neurosurgery, and psychiatry. 69(4)
Cerebral malaria may be the most common non-traumatic encephalopathy in the world. The pathogenesis is heterogenous and the neurological complications are often part of a multisystem dysfunction. The clinical presentation and pathophysiology differs
Autor:
F H, Osier, C R, Newton
Publikováno v:
East African medical journal. 76(12)
A case of fibrocalculous pancreatic diabetes in a 12-year old boy is described. A medline literature search back to 1966 revealed that no cases had been reported from East Africa. We reviewed the literature and suggest that the condition is probably